Results 121 to 130 of about 34,994 (236)

Expert Consensus on the Diagnosis and Treatment of FGFR Gene-Altered Solid Tumors

Global Medical Genetics
The fibroblast growth factor receptor (FGFR) is a crucial receptor tyrosine kinase involved in essential biological processes, including growth, development, and tissue repair.
Chunwei Xu, Bin Lian, Juanjuan Ou, Qian Wang, Wenxian Wang, Ke Wang, Dong Wang, Zhengbo Song, Aijun Liu, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Wen Li, Lili Mao, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Long Huang, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Rui Ge, Enyong Dai, Yu Han, Weiwei Pan, Fei Pang, Jintao Huang, Kai Wang, Fan Wu, Bingwei Xu, Liping Wang, Youcai Zhu, Li Lin, Yanru Xie, Xinqing Lin, Jing Cai, Ling Xu, Jisheng Li, Xiaodong Jiao, Kainan Li, Jia Wei, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yue Feng, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Zhaofeng Wang, Yue Hao, Zhen Wang, Bin Wan, Donglai Lv, Zhanqiang Zhai, Shengjie Yang, Jing Kang, Jiatao Zhang, Chao Zhang, Lin Shi, Yina Wang, Bihui Li, Zhang Zhang, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Huijuan Wang, Gu Jin, Guansong Wang, Jiandong Wang, Meiyu Fang, Yong Fang, Yuan Li, Xiaojia Wang, Jing Chen, Yiping Zhang, Xixu Zhu, Yi Shen, Shenglin Ma, Biyun Wang, Lu Si, Yuanzhi Lu, Ziming Li, Wenfeng Fang, Yong Song   +123 more
doaj   +1 more source

Future applications of FGF/FGFR inhibitors in cancer

, 2018
Deregulation of the fibroblast growth factor (FGF)/FGF receptor (FGFR) network occurs frequently in tumors due to gene amplification, activating mutations, and oncogenic fusions.
GHEDINI, Gaia Cristina, Marco Presta, Arianna Giacomini, Ronca roberto   +3 more
core   +1 more source

HPV‐Associated Adenosquamous Carcinoma of the Oropharynx With a PARD3B::ERBB4 Fusion

Genes, Chromosomes and Cancer, Volume 65, Issue 9, September 2026.
ABSTRACT Head and neck carcinomas can be diagnostically challenging because of their diverse histologic subtypes. We report a case of a 55‐year‐old male presenting with right‐sided cervical adenopathy, in whom imaging revealed a cystic lesion that was subsequently confirmed to be metastatic from a lesion at the base of the tongue.
Seddig Momenkhan, Jacques Blanc, Pierre Philouze, Jonathan Lopez, Francoise Descotes, Eudeline Alix, Camille Leonce, Ziyad Alsugair, Nazim Benzerdjeb   +8 more
wiley   +1 more source

Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function

Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley   +1 more source

Sequential Fibroblast Growth Factor Receptor Inhibition in Intrahepatic Cholangiocarcinoma: Navigating an Evolving Landscape of Resistance and Opportunity—A Case Report and Current Opinion

Oncology and Therapy
Fibroblast growth factor receptor ( FGFR ) 2 rearrangements define a distinct molecular subset of intrahepatic cholangiocarcinoma (iCCA) with therapeutic potential using FGFR inhibitors.
Hideki Sasanuma, Hironori Yamaguchi
doaj   +1 more source

Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post‐stroke neurorepair

Neuroprotection, Volume 4, Issue 3, Page 213-228, September 2026.
ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan, Madeleine J. Smith, Simon F. R. Hinkley, Andrew N. Clarkson   +3 more
wiley   +1 more source

A Simple Cell Culture Assay for Human Prostatic Branching Morphogenesis Spotlights Bone Morphogenetic Protein Signaling as a Therapeutic Target in Benign Prostatic Hyperplasia

The Prostate, Volume 86, Issue 13, Page 1332-1340, September 15, 2026.
ABSTRACT Background Benign prostatic hyperplasia (BPH) leads to prostate enlargement and lower urinary tract symptoms that can resist treatment. A histologic hallmark of BPH is glandular epithelial hyperplasia with new ductal branching morphogenesis. The stromal inductive factors driving tissue morphogenesis may provide new therapeutic targets, but are
Anna S. Pollack, James D. Brooks, Jonathan R. Pollack   +2 more
wiley   +1 more source

Advances and challenges in targeting FGFR signalling in cancer

, 2016
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported ...
Irina S. Babina, Nicholas C. Turner, Turner, NC, Babina, IS   +3 more
core   +1 more source

Harmonized Acquisition of Connectome MRI and Clinical Data for Stroke, Parkinson's Disease and Glioma: Delphi‐Derived Protocol Recommendations by the European Academy of Neurology

European Journal of Neurology, Volume 33, Issue 9, September 2026.
In the context of the Horizon Europe EBRAINS 2.0 research consortium, Delphi‐derived, consented protocol recommendations from European Academy of Neurology Scientific Panel experts provide a pragmatic framework for harmonizing multi‐scale data acquisition for connectome analyses in stroke, Parkinson's Disease, and glioma.
Thomas Berger, Lorenzo Pini, Alessandro Salvalaggio, Simone Cauzzo, Christine Klein, Maria Lolich, Alberto Picca, Dauren Ramankulov, Maria A. Rocca, Roberta Rudà, Alessandro Sodero, Alessandro Tessitore, Thomas Truelsen, Roland Wiest, Gereon R. Fink, Elena Moro, Philippe Ryvlin, Maurizio Corbetta   +17 more
wiley   +1 more source

Oral Nintedanib for Refractory Generalized Keloids: A Prospective Exploratory Pilot Study

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Generalized keloids are severe, treatment‐refractory, disfiguring dermatoses that substantially impair physical and psychosocial well‐being and have limited effective systemic treatment options. Objective To assess the short‐term safety, tolerability, and exploratory clinical outcomes of oral nintedanib in patients with refractory ...
Chenmei Liu, Lian Zhang, Dan Sun, Aiqing Lin, Renliang He, Bin Yang   +5 more
wiley   +1 more source