Results 101 to 110 of about 7,115 (188)

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

FGFR1 and IGFBP5 protein expression by immunohistochemistry in uterine leiomyomas.

, 2013
(A) FGFR1-adjacent normal myometrium showing FGFR1 low level expression (score 1); (B) and (C) FGFR1 cytoplasmic positive expression in uterine leiomyoma tissue (scores 2 and 3/intensity, respectively); (D) adjacent normal myometrium showing IGFBP5 ...
Maria Aparecida Custódio Domingues (384891), Priscila Daniele Ramos Cirilo (384887), Silvia Regina Rogatto (384893), Igor Jurisica (1288), Anagloria Pontes (384892), Rafael Malagoli Rocha (384890), Mateus de Camargo Barros Filho (384889), Fábio Albuquerque Marchi (384888)   +7 more
core   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis

Cell Communication and Signaling
Fibroblast growth factor receptor 1 (FGFR1) is a N-glycosylated cell surface receptor tyrosine kinase, which upon recognition of specific extracellular ligands, fibroblast growth factors (FGFs), initiates an intracellular signaling.
Dominika Żukowska, Aleksandra Chorążewska, Krzysztof Ciura, Aleksandra Gędaj, Marta Kalka, Marta Poźniak, Natalia Porębska, Łukasz Opaliński   +7 more
doaj   +1 more source

Change‐of‐function fibroblast growth factor receptor 3 mutations causing skeletal dysplasias

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
We show that the ligands FGF1 and FGF2 elicit differential fibroblast growth factor receptor 3 (FGFR3) signaling responses and that the FGFR3 G380R and A391E mutations reshape these signaling outputs. Thus, pathogenic FGFR3 mutations found in skeletal dysplasia do not simply enhance signaling strength and should be reclassified from “gain‐of‐function ...
Tanaya Roy, Zuzana Feketova, Jiawei Liu, Pavel Krejci, Kalina Hristova   +4 more
wiley   +1 more source

Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits

Glia, Volume 74, Issue 12, December 2026.
To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom, Shweta Tendulkar, Amber R. Hackett, Amy Strickland, Yurie Sato‐Yamada, Liya Yuan, Wendy Dong, Joseph Ippolito, Robert E. Schmidt, Yo Sasaki, Aaron DiAntonio, Jeffrey Milbrandt   +11 more
wiley   +1 more source

Supplementary Figure S1. FGFR1 protein expression and FGFR1 gene copy-numbers in HPV-positive and HPV-negative head and neck squamous cell carcinoma. from FGFR1 Is a Potential Prognostic Biomarker and Therapeutic Target in Head and Neck Squamous Cell Carcinoma

, 2016
(A) FGFR1 protein overexpression and low FGFR1 expression in HPV-positive and HPV-negative head and neck squamous cell carcinoma patients. FGFR1 protein was overexpressed in 82% of HPV-positive and 75% of HPV-negative head and neck squamous cell ...
Pauline M.W. van Kempen (14995977), Cor Lieftink (6016799), Rob Noorlag (14995980), Stefan M. Willems (8941127), Diede Brunen (352940), Robert J.J. van Es (14995983), René Bernards (82847), Koos Koole (14995974), Remco de Bree (60703)   +8 more
core   +1 more source

FGFR1 expression levels predict BGJ398 Sensitivity of FGFR1-dependent head and neck Squamous cell cancers [PDF]

, 2015
Purpose: FGFR1 copy-number gain (CNG) occurs in head and neck squamous cell cancers (HNSCC) and is used for patient selection in FGFR-specific inhibitor clinical trials.
Sharma, Rakesh, Göke, Antonia, Schroeck, Andreas, Boehm, Diana, Perner, Sven, Kleczko, Emily, Hirsch, Fred, Jimeno, Antonio, Heasley, Lynn, Göke, Friederike, Hinz, Trista, Kirsten, Robert, Yoon, Petros, Marek4, Lindsay, Vogel, Wenzel, Bremen, Tobias, Franzen, Alina, Golletz, Carsten, Bootz, Friedrich, Bode, Maike, Tan, Aik-Choon, Lankat-Buttgereit, Brigitte, Eagles-Soukup, Justin, Maessenhausen, Anne   +23 more
core   +1 more source

Defective FGFR1 Signaling Disrupts Glucose Regulation: Evidence From Humans With FGFR1 Mutations

Journal of the Endocrine Society
Abstract Context Activation of fibroblast growth factor receptor 1 (FGFR1) signaling improves the metabolic health of animals and humans, while inactivation leads to diabetes in mice. Direct human genetic evidence for the role of FGFR1 signaling in human metabolic health has not been fully established.
Maria I Stamou, Crystal J Chiu, Shreya V Jadhav, Vanessa Ferreira Lopes, Kathryn B Salnikov, Lacey Plummer, Margaret F Lippincott, Hang Lee, Stephanie B Seminara, Ravikumar Balasubramanian   +9 more
openaire   +2 more sources

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, Volume 159, Issue 11, Page 2736-2754, 1 December 2026.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source