Results 111 to 120 of about 7,115 (188)

FGFR1OP (FGFR1 oncogene partner)

, 2001
Review on FGFR1OP (FGFR1 oncogene partner), with data on DNA, on the protein encoded, and where the gene is ...
Pébusque, MJ
core   +1 more source

The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)

Haematologica, 2011
We report a patient with T-lymphoblastic leukemia/lymphoma and a t(7;8)(q22;p11). CUX1 was identified as the fusion partner of FGFR1 by fluorescence in situ hybridization and 5′ RACE-PCR.
Bartosz Wasag, Els Lierman, Peter Meeus, Jan Cools, Peter Vandenberghe   +4 more
doaj   +1 more source

TRAF3IP3::FGFR1: a novel FGFR1 fusion identified in an aggressive case of acute myeloid leukemia

Annals of Hematology
Abstract Myeloid/lymphoid neoplasms with tyrosine kinase gene fusions (MLN-TK) are rare hematologic malignancies characterized by recurrent kinase rearrangements, including FGFR1 , often associated with aggressive clinical behavior.
Chen, Xue, Yuan, Lili, Ma, Xiaoli, Wang, Fang, Zhang, Yang, Cao, Panxiang, Wu, Ping, Wang, Tong, Chen, Jiaqi, Zhou, Xiaosu, Liu, Hongxing   +10 more
openaire   +2 more sources

Differential FGFR1 copy number status displays unique tumour immune microenvironment in triple‐negative breast cancer

The Journal of Pathology, Volume 270, Issue 4, Page 507-520, December 2026.
Abstract Fibroblast growth factor receptor 1 (FGFR1) amplification, a significant cancer alteration with both prognostic and therapeutic relevance, lacks a standardized definition. The relationship between FGFR1 copy number (CN) variations and tumour microenvironment (TME) characteristics also remains poorly understood.
Yike Gao, Fei Yao, Junyi Pang, Tianlin Sun, Changbin Zhu, Shafei Wu, Zhiyong Liang   +6 more
wiley   +1 more source

Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia [PDF]

, 2019
We report two patients with leukaemia driven by the rare CNTRL-FGFR1 fusion oncogene. This fusion arises from a t(8;9)(p12;q33) translocation, and is a rare driver of biphenotypic leukaemia in children.
Schmidt, B, Oshlack, A, Davidson, NM, Khaw, SL, Ekert, PG, Bartolo, RC, Mechinaud, F, Challis, J, Petrovic, V, Majewski, IJ, Brown, LM, Khuong-Quang, DA, Brooks, I   +12 more
core   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, Volume 117, Issue 6, Page 1485-1499, December 2026.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Membrane-Associated, Not Cytoplasmic or Nuclear, FGFR1 Induces Neuronal Differentiation

, 2019
The intracellular transport of receptor tyrosine kinases results in the differential activation of various signaling pathways. In this study, optogenetic stimulation of fibroblast growth factor receptor type 1 (FGFR1) was performed to study the effects ...
Katalin Csanaky, Michael W. Hess, Lars Klimaschewski, Michael W. Hess   +3 more
core   +1 more source

Treatment of the myeloid/lymphoid neoplasm with FGFR1 rearrangement with FGFR1 inhibitor [PDF]

Annals of Oncology, 2018
S. Verstovsek, V. Subbiah, L. Masarova, C. Cameron Yin, G. Tang, T. Manshouri, E. Asatiani, N.G. Daver   +7 more
openaire   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

FGFR1/FOXM1 pathway: a key regulator of glioblastoma stem cells radioresistance and a prognosis biomarker

, 2018
International audienceGlioblastoma are known to be aggressive and therapy-resistant tumors, due to the presence of glioblastoma stem cells inside this heterogeneous tumor. We investigate here the involvement of FGFR1 in glioblastoma stem-like cells (GSLC)
Gouazé-Andersson, Valérie, Arnauduc, Florent, Lemarié, Anthony, Lubrano, Vincent, Toulas, Christine, Ghérardi, Marie-Julie, Gilhodes, Julia, Cohen-Jonathan Moyal, Elizabeth, Cohen-Jonathan-Moyal, Elizabeth   +8 more
core   +1 more source