Results 131 to 140 of about 7,115 (188)

Biliary Abnormality on Imaging During Lenvatinib Plus Hepatic Arterial Infusion Chemotherapy With Cisplatin for Hepatocellular Carcinoma: A Pilot Descriptive Study

Hepatology Research, Volume 56, Issue 11, Page 1575-1585, November 2026.
ABSTRACT Aim To evaluate the frequency, imaging characteristics, associated factors, and clinical significance of biliary abnormalities on imaging in patients receiving lenvatinib (LEN) plus cisplatin hepatic arterial infusion chemotherapy (HAIC) for hepatocellular carcinoma (HCC).
Hirohito Osanai, Kazuto Kozaka, Takashi Matsubara, Norihide Yoneda, Takahiro Ogi, Kenichiro Okumura, Atsushi Takamatsu, Azusa Kitao, Shintaro Yagi, Taro Yamashita, Satoshi Kobayashi   +10 more
wiley   +1 more source

Bazi Bushen Attenuates Skeletal Muscle Decline Associated With Oestrogen Deficiency and Modulates FGFR1/ERK Signalling

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Postmenopausal oestrogen deficiency is associated with skeletal muscle loss and functional decline, thereby increasing the risk of sarcopenia in women. Considering the safety risks linked to hormone replacement therapy (HRT), alternative strategies are needed to attenuate skeletal muscle decline after menopause.
Dezhi Huang, Na Xu, Qi Chu, Zhenhua Jia, Yan Wang, Jin Xu   +5 more
wiley   +1 more source

HuR Confers Resistance of Hepatocellular Carcinoma to Lenvatinib by Inhibiting Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT This study aim to explore whether human antigen R (HuR) inhibits ferroptosis confers resistance to lenvatinib in hepatocellular carcinoma (HCC). Bioinformatics analysis and immunofluorescence detection of 30 HCC tissue samples were used to verify the clinical correlation between HuR and glutathione peroxidase 4 (GPX4), establish a lenvatinib ...
Siren Feng, Fang Wang, Huayi Wu, Xinran Lin, Xue Qi, Kun Liu, Qiushi Yin, Bo Lin, Mengsen Li, Mingyue Zhu   +9 more
wiley   +1 more source

Early‐Life Betaine Supplementation Drives Sex‐Specific Metabolic Programming in Rats, Affecting FGF21 Signaling and Energy Balance

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A maternal western diet (WD) and betaine supplementation during suckling influence metabolic programming. A maternal WD induced adverse metabolic effects in offspring, accompanied by altered FGF21‐related gene expression and decreased Akkermansia muciniphila abundance.
Rocío A. Martín‐Chamorro, Catalina A. Pomar, Andreu Palou, Catalina Picó, Ana M. Rodríguez   +4 more
wiley   +1 more source

S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner

, 2011
S100B protein has been shown to exert anti-myogenic and mitogenic effects in myoblast cultures through inhibition of the myogenic p38 MAPK and activation of the mitogenic ERK1/2. However, the receptor mediating these effects had not been identified. Here,
Francesca Riuzzi, Guglielmo Sorci, DONATO, Rosario Francesco, Rosario Donato, SORCI, Guglielmo, RIUZZI, Francesca   +5 more
core   +1 more source

FGFR1 Gene [PDF]

, 2020
openaire   +1 more source

FGFR1 Positive [PDF]

, 2020
openaire   +1 more source

Healthy Participant Versus Patient Selection for Clinical Pharmacology Studies in Small‐Molecule Oncology Drug Development

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
Paridhi Gupta, Zheyi Hu, Li Zhu, Lora Hamuro   +3 more
wiley   +1 more source

Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases

Nature Communications
Estrogen receptor-positive breast cancer represents a significant proportion of breast cancer brain metastasis but remains understudied. Here we show that FGFR1-amplification, a well-established driver of estrogen receptor-positive breast cancer ...
Morgan S. Fox, Jenny A. Jaramillo-Gómez, R. Alejandro Marquez-Ortiz, Karen L. F. Alvarez-Eraso, Maria J. Contreras-Zárate, Trinh C. Pham, Elaina N. Barela, Stella N. Koliavas, Peter Kabos, Natalie J. Serkova, Carol A. Sartorius, Elizabeth A. Wellberg, Diana M. Cittelly   +12 more
doaj   +1 more source

FGFR1 drives metabolic adaptation associated with temozolomide resistance in glioblastoma

Therapy resistance is a major limitation in therapeutic efficacy for glioblastoma (GBM) patients, positioning GBM among the deadliest tumor types. In this work, we have dissected resistance mechanisms in GBM, which resulted in the identification of FGFR1
Durán, Raúl V, Oltra, Sara S, Tomé, Mercedes, Murdoch, Piedad Del Socorro, Martín-Montalvo, Jorge, Rattigan, Kevin M, Reina-Bando, Ana, Zarzuela, Laura, Morillo-Huesca, Macarena, Ceballos-Chávez, María, Reyes, José C, Helgason, G Vignir, Sierra-Párraga, Jesús M, Moreno-Bueno, Gema, Sánchez-Escabias, Elena, Capilla-González, Vivian, López-Cepero, Ignacio G, Reyes, José C., Sierra-Párraga, Jesús M., López-Cepero, Ignacio G., Durán, Raúl V., Oltra, Sara S., Helgason, G. Vignir, Rattigan, Kevin M.   +23 more
core   +1 more source