Results 151 to 160 of about 7,115 (188)
Myeloid and lymphoid neoplasm with FGFR1 abnormality [PDF]
British Journal of Haematology, 2009 Keane, Colm +3 more
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FGFR1 Antibody Validation and Characterization of FGFR1 Protein Expression in ER+ Breast Cancer
Applied Immunohistochemistry & Molecular Morphology, 2022Clinical trials in patients with ER+ breast cancer with or without FGFR pathway somatic alterations have shown limited clinical benefit from treatment with FGFR tyrosine kinase inhibitors alone or in combination with endocrine therapy. This is likely because of an inadequate predictive biomarker to select appropriate patients.
Gonzalez-Ericsson, Paula I +6 more
openaire +3 more sources
High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1
International Journal of Molecular Sciences, 2018 Fibroblast growth factor receptor 1 (FGFR1) is a plasma membrane protein that transmits signals from the extracellular environment, regulating cell homeostasis and function.
Malgorzata Zakrzewska +2 more
exaly +2 more sources
Prognostic Role of FGFR1 Amplification in Early-Stage Non-Small Cell Lung Cancer [PDF]
British Journal of Cancer, 2014 Background:Recently, fibroblast growth factor receptor 1 (FGFR1) was discovered in squamous cell carcinomas (SCC) of the lung with FGFR1 amplification described as a promising predictive marker for anti-FGFR inhibitor treatment.
Nikola Cihoric, I Zlobec, S Savic
exaly +3 more sources
FGFR1 and FGFR2 Mutations in Pfeiffer Syndrome
Journal of Craniofacial Surgery, 2013Pfeiffer syndrome (PS) (MIM 101600) is one of the most common syndromic forms of craniosynostosis. It is characterized by craniosysnostosis, midface hypoplasia, broad and medially deviated thumbs, and great toes with partial syndactyly of the digits. Here, we described clinical and genetic features of 12 unrelated Thai individuals with PS.
Chayanin, Chokdeemboon +5 more
openaire +2 more sources
Abstract A20: FGFR1-amplified squamous cell lung cancers depend on FGFR1
Clinical Cancer Research, 2010Abstract In lung adenocarcinomas of never-smokers EGFR mutations or EML4-ALK gene fusions are frequent genomic events that both expose prime therapeutic targets. By contrast, squamous cell lung cancer (SQLC) is almost invariably associated with smoking; in this subgroup of patients, no attractive therapeutic target has so far been ...
Martin L. Sos, Roman K. Thomas
openaire +1 more source
Virchows Archiv, 2016
Although lung cancer continues to be the leading cause of cancer-related death, accurate diagnosis followed by personalized treatment is expected to raise the 5-year survival rate. Targeted therapies are now in routine clinical use, in particular for lung adenocarcinoma (ADC).
Vitor, Sousa +8 more
openaire +2 more sources
Although lung cancer continues to be the leading cause of cancer-related death, accurate diagnosis followed by personalized treatment is expected to raise the 5-year survival rate. Targeted therapies are now in routine clinical use, in particular for lung adenocarcinoma (ADC).
Vitor, Sousa +8 more
openaire +2 more sources