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Oral Oncology, 2007
Chromosomal aberrations are known to have an impact on the initiation and progression of oral squamous cell carcinoma (OSCC), but individual genes involved in OSCC pathogenesis are poorly described. To elucidate the molecular events underlying oral carcinogenesis, a set of primary OSCC were screened for distinct genetic imbalances by means of array ...
Kolja, Freier +8 more
openaire +2 more sources
Chromosomal aberrations are known to have an impact on the initiation and progression of oral squamous cell carcinoma (OSCC), but individual genes involved in OSCC pathogenesis are poorly described. To elucidate the molecular events underlying oral carcinogenesis, a set of primary OSCC were screened for distinct genetic imbalances by means of array ...
Kolja, Freier +8 more
openaire +2 more sources
Journal of Hematopathology
Background Myeloid/lymphoid neoplasm with eosinophilia and rearrangement of FGFR1(MLN-FGFR1), also referred to as 8p11 myeloproliferative syndrome (EMS), arises from aberrant FGFR1 gene rearrangement in bone marrow hematopoietic stem cells, resulting in the transformation of myeloid/lymphoid cells into neoplastic growths.
Xianqi, Feng +9 more
openaire +2 more sources
Background Myeloid/lymphoid neoplasm with eosinophilia and rearrangement of FGFR1(MLN-FGFR1), also referred to as 8p11 myeloproliferative syndrome (EMS), arises from aberrant FGFR1 gene rearrangement in bone marrow hematopoietic stem cells, resulting in the transformation of myeloid/lymphoid cells into neoplastic growths.
Xianqi, Feng +9 more
openaire +2 more sources
2010
Proteinkinase FGFR1 plays a key role in angiogenesis regulation and tumor proliferation. Inhibitors of this kinase can be used for effective treatment of solid tumors and proliferative diseases. FGFR1 inhibitors searching were performed among 3500 chromone derivatives by virtual screening and in vitro testing.
openaire +1 more source
Proteinkinase FGFR1 plays a key role in angiogenesis regulation and tumor proliferation. Inhibitors of this kinase can be used for effective treatment of solid tumors and proliferative diseases. FGFR1 inhibitors searching were performed among 3500 chromone derivatives by virtual screening and in vitro testing.
openaire +1 more source