Results 41 to 50 of about 36,269 (231)
FGFR2 alterations in endometrial carcinoma [PDF]
Modern Pathology, 2011 Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor involved in many biological processes such as embryogenesis, adult tissue homeostasis and cell proliferation. Mutations in FGFR2 have been reported in up to 10-12% of endometrial carcinomas identical to those found in congenital craniofacial disorders.
Gatius, S +8 more
openaire +3 more sources
Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression. [PDF]
PLoS ONE, 2010 Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell lines treated with the EGFR TKI, gefitinib, revealed increased levels of FGFR2 ...
Kathryn E Ware +8 more
doaj +1 more source
Tripod-shaped Syndactyly in Apert Syndrome with FGFR2 p.P253R Mutation
Indian Journal of Plastic Surgery, 2021 Apert syndrome is a rare acrocephalosyndactyly (craniosynostosis) syndrome characterized by craniofacial dysmorphism and syndactyly of the hands and feet. It is caused by FGFR2 mutations and inherited in an autosomal dominant manner.
Chandra Bhan Singh +4 more
doaj +1 more source
Targeting FGFR2 Positive Gastroesophageal Cancer: Current and Clinical Developments
OncoTargets and Therapy, 2022 Despite recent advances in the systemic treatment of gastroesophageal cancers, prognosis remains poor. Comprehensive molecular analyses have characterized the genomic landscape of gastroesophageal cancer that has established therapeutic targets such as ...
Anderley Gordon +3 more
semanticscholar +1 more source
International Journal of General Medicine, 2020 Attapol Titapun,1,2 Anchalee Techasen,2,3 Prakasit Sa-Ngiamwibool,2,4 Paiboon Sithithaworn,2,5 Vor Luvira,1,2 Tharatip Srisuk,1,2 Apiwat Jareanrat,1,2 Hasaya Dokduang,2,6 Watcharin Loilome,2,6 Bandit Thinkhamrop,2,7 Narong Khuntikeo1,2 1Department of ...
Titapun A +10 more
doaj
Cancer Management and Research, 2021 Massimiliano Salati,1,2 Francesco Caputo,1 Cinzia Baldessari,1 Pietro Carotenuto,3 Marco Messina,4 Stefania Caramaschi,5 Massimo Dominici,1 Luca Reggiani Bonetti5 1Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy; 2PhD ...
Salati M +7 more
doaj
BMC Research Notes, 2020 Objective Fibroblast growth factor receptor (FGFR) 2 regulates the development of the adrenal gland in mice. In addition, FGFR2-mediated signalling has been shown to prevent apoptosis and to enhance proliferation in adrenocortical precursor cells.
Matthias Haase +5 more
doaj +1 more source
Fibroblast growth factor receptor 2 (FGFR2) is required for corneal epithelial cell proliferation and differentiation during embryonic development. [PDF]
PLoS ONE, 2015 Fibroblast growth factors (FGFs) play important roles in many aspects of embryonic development. During eye development, the lens and corneal epithelium are derived from the same surface ectodermal tissue.
Jinglin Zhang +3 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of AmericaSignificance Existing targeted therapies for solid tumors harboring FGFR2 alterations include pan-FGFR inhibitors, which often cannot be dosed to maximum efficacy due to FGFR1- and FGFR4-mediated toxicities.
Heike Schönherr +28 more
semanticscholar +1 more source
Clinical Features of Apert Syndrome in Infancy: A rare case in Indonesia
Scripta Score Scientific Medical Journal, 2021 Background: Apert syndrome is characterized by several malformations of cranial-facial and syndactyly. The incidence of Apert syndrome was reported at approximately 1 per 65,000 live births, globally.
Muhammad Pradhika Mapindra +1 more
doaj +1 more source