Results 71 to 80 of about 36,269 (231)

Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma

npj Precision Oncology, 2021
Intrahepatic cholangiocarcinoma (iCCA) has emerged as a promising candidate for precision medicine, especially in the case of activating FGFR2 gene fusions.
Michael Bitzer, Stephan Spahn, Sepideh Babaei, Marius Horger, Stephan Singer, Klaus Schulze-Osthoff, Pavlos Missios, Sergios Gatidis, Dominik Nann, Sven Mattern, Veit Scheble, Konstantin Nikolaou, Sorin Armeanu-Ebinger, Martin Schulze, Christopher Schroeder, Saskia Biskup, Janina Beha, Manfred Claassen, Kristina Ruhm, Antti Poso, Nisar P. Malek   +20 more
doaj   +1 more source

FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cells.

Gene, 2022
The multilineage differentiation potential of human mesenchymal stem cells (hMSCs) underpins their clinical utility for tissue regeneration. Control of such cell-fate decisions is tightly regulated by different growth factors/cytokines and their cognate ...
Ying Zhang, L. Ling, Arya Ajay D/O Ajayakumar, Yating Michelle Eio, A. V. van Wijnen, V. Nurcombe, S. Cool   +6 more
semanticscholar   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype

BMC Research Notes, 2011
Background Single Nucleotide Polymorphisms (SNPs) in intron 2 of the Fibroblast Growth Factor Receptor Type 2 (FGFR2) gene, including rs2981582, contribute to multifactorial breast cancer susceptibility.
Thompson Alastair M, Purdie Colin A, Quinlan Philip R, Baker Lee, Palmer Colin N, Ashfield Alison M, Grant Andrew, Martin Amy J, Jordan Lee B, Berg Jonathan N   +9 more
doaj   +1 more source

Inhibition of FGFR2 Signaling by Cynaroside Attenuates Liver Fibrosis

Pharmaceuticals, 2023
Liver fibrosis represents a significant health hazard with a high morbidity rate and an increased risk of liver cancer. Targeting overactivated Fibroblast growth factor receptor 2 (FGFR2) is a promising strategy to counteract collagen accumulation during
Qilin Meng, Lin Luo, Minghua Lei, Zhiqi Chen, Yuanmeng Sun, Xue Chen, Zhaodong Zhai, Yibo Zhang, Jieqiong Cao, Zijian Su, Fu Li, Jingsheng Li, An Hong, Xiaojia Chen   +13 more
doaj   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

FGF7/FGFR2–JunB signalling counteracts the effect of progesterone in luminal breast cancer

Molecular Oncology, 2022
We have recently demonstrated that fibroblast growth factor receptor 2 (FGFR2)‐mediated signalling alters progesterone receptor (PR) activity and response of oestrogen receptor α (ER)‐positive (ER+) breast cancer (BCa) cell lines to anti‐ER agents ...
Kamil Mieczkowski, Kamila Kitowska, Marcin Braun, Barbara Galikowska-Bogut, Monika Gorska-Arcisz, Dominika Piasecka, K. Stawiski, A. Żaczek, D. Nejc, R. Kordek, H. Romanska, R. Sądej   +11 more
semanticscholar   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

FGFR2 as A Prognostic and Predictive Marker in Colorectal Adenocarcinoma Based on TILs Grade

Indonesian Biomedical Journal
BACKGROUND: Colorectal cancer remains a serious health problem due to its high incidence and mortality rate each year. Histopathological grades and tumor-infiltrating lymphocytes (TILs) are associated with patient’s outcome.
Andi Marcha Rianti, Muhammad Husni Cangara, Amalia Yamin, Haslindah Dahlan, Muhammad Riza Ilyasa, Upik Anderiani Miskad   +5 more
doaj   +1 more source

FGFR2 Mutation p.Cys342Arg Enhances Mitochondrial Metabolism-Mediated Osteogenesis via FGF/FGFR-AMPK-Erk1/2 Axis in Crouzon Syndrome

Cells, 2022
Background: Crouzon syndrome ([OMIM] #123500) caused by FGFR2 mutation is an autosomal dominant syndrome with craniosynostosis, the underlying mechanism of which remains obscure.
Yidi Wang, Yue Liu, Haotian Chen, Xiaojing Liu, Yi Zhang, Yixiang Wang, Yan Gu   +6 more
doaj   +1 more source