Results 71 to 80 of about 35,241 (222)

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype

BMC Research Notes, 2011
Background Single Nucleotide Polymorphisms (SNPs) in intron 2 of the Fibroblast Growth Factor Receptor Type 2 (FGFR2) gene, including rs2981582, contribute to multifactorial breast cancer susceptibility.
Thompson Alastair M, Purdie Colin A, Quinlan Philip R, Baker Lee, Palmer Colin N, Ashfield Alison M, Grant Andrew, Martin Amy J, Jordan Lee B, Berg Jonathan N   +9 more
doaj   +1 more source

FGF7/FGFR2–JunB signalling counteracts the effect of progesterone in luminal breast cancer

Molecular Oncology, 2022
We have recently demonstrated that fibroblast growth factor receptor 2 (FGFR2)‐mediated signalling alters progesterone receptor (PR) activity and response of oestrogen receptor α (ER)‐positive (ER+) breast cancer (BCa) cell lines to anti‐ER agents ...
Kamil Mieczkowski, Kamila Kitowska, Marcin Braun, Barbara Galikowska-Bogut, Monika Gorska-Arcisz, Dominika Piasecka, Konrad Stawiski, A. Żaczek, D. Nejc, R. Kordek, H. Romanska, R. Sądej   +11 more
semanticscholar   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma

npj Precision Oncology, 2021
Intrahepatic cholangiocarcinoma (iCCA) has emerged as a promising candidate for precision medicine, especially in the case of activating FGFR2 gene fusions.
Michael Bitzer, Stephan Spahn, Sepideh Babaei, Marius Horger, Stephan Singer, Klaus Schulze-Osthoff, Pavlos Missios, Sergios Gatidis, Dominik Nann, Sven Mattern, Veit Scheble, Konstantin Nikolaou, Sorin Armeanu-Ebinger, Martin Schulze, Christopher Schroeder, Saskia Biskup, Janina Beha, Manfred Claassen, Kristina Ruhm, Antti Poso, Nisar P. Malek   +20 more
doaj   +1 more source

TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma.

Cancer Discovery, 2019
ATP-competitive Fibroblast Growth Factor Receptor (FGFR) kinase inhibitors, including BGJ398 and Debio1347, show antitumor activity in patients with intrahepatic cholangiocarcinoma (ICC) harboring activating FGFR2 gene fusions.
L. Goyal, Lei Shi, Leah Y. Liu, F. Fece de la Cruz, Jochen K. Lennerz, Srivatsan Raghavan, Ignaty Leschiner, Liudmila Elagina, G. Siravegna, Raymond W. S. Ng, P. Vu, K. Patra, Supriya K. Saha, R. Uppot, Ron Arellano, Stephanie Reyes, T. Sagara, S. Otsuki, Brandon Nadres, Heather A. Shahzade, I. Dey‐Guha, Isobel J. Fetter, I. Baiev, Emily E. Van Seventer, Janet E. Murphy, C. Ferrone, Kenneth K. Tanabe, V. Deshpande, J. Harding, R. Yaeger, R. Kelley, A. Bardelli, A. Iafrate, William C. Hahn, C. Benes, David T. Ting, H. Hirai, G. Getz, D. Juric, Andrew X. Zhu, R. Corcoran, N. Bardeesy   +41 more
semanticscholar   +1 more source

Noninvasive Detection of Polyclonal Acquired Resistance to FGFR Inhibition in Patients With Cholangiocarcinoma Harboring FGFR2 Alterations

JCO Precision Oncology, 2021
PURPOSE Fibroblast growth factor receptor (FGFR) 2 alterations, present in 5%-15% of intrahepatic cholangiocarcinomas (IHC), are targets of FGFR-directed therapies. Acquired resistance is common among patients who respond.
A. Varghese, J. Patel, Y. Janjigian, Fanli Meng, S. D. Selcuklu, G. Iyer, B. Houck-Loomis, J. Harding, E. O’Reilly, G. Abou-Alfa, M. Lowery, M. Berger   +11 more
semanticscholar   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

FGFR2 as A Prognostic and Predictive Marker in Colorectal Adenocarcinoma Based on TILs Grade

Indonesian Biomedical Journal
BACKGROUND: Colorectal cancer remains a serious health problem due to its high incidence and mortality rate each year. Histopathological grades and tumor-infiltrating lymphocytes (TILs) are associated with patient’s outcome.
Andi Marcha Rianti, Muhammad Husni Cangara, Amalia Yamin, Haslindah Dahlan, Muhammad Riza Ilyasa, Upik Anderiani Miskad   +5 more
doaj   +1 more source