Results 81 to 90 of about 36,269 (231)

TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma.

Cancer Discovery, 2019
ATP-competitive Fibroblast Growth Factor Receptor (FGFR) kinase inhibitors, including BGJ398 and Debio1347, show antitumor activity in patients with intrahepatic cholangiocarcinoma (ICC) harboring activating FGFR2 gene fusions.
L. Goyal, Lei Shi, Leah Y. Liu, F. Fece de la Cruz, Jochen K. Lennerz, Srivatsan Raghavan, Ignaty Leschiner, Liudmila Elagina, G. Siravegna, Raymond W. S. Ng, P. Vu, K. Patra, S. Saha, R. Uppot, Ron Arellano, Stephanie Reyes, T. Sagara, S. Otsuki, Brandon Nadres, Heather A. Shahzade, I. Dey‐Guha, Isobel J. Fetter, I. Baiev, Emily E. Van Seventer, Janet E. Murphy, C. Ferrone, Kenneth K. Tanabe, V. Deshpande, J. Harding, R. Yaeger, R. Kelley, A. Bardelli, A. Iafrate, William C. Hahn, C. Benes, David T. Ting, H. Hirai, G. Getz, D. Juric, Andrew X. Zhu, R. Corcoran, N. Bardeesy   +41 more
semanticscholar   +1 more source

Fetal microtia and FGFR2 polymorphism

Experimental and Therapeutic Medicine, 2019
Association of the single-nucleotide polymorphism (SNP) of rs3135718 site in fibroblast growth factor receptor 2 (FGFR2) gene with congenital microtia was investigated. A total of 193 patients with congenital microtia (observation group) and 150 normal and healthy fetuses (control group) treated in Maternity and Child Health Care of Zaozhuang from ...
Zhao, Ruilian, Du, Peixia, Sun, Hongmei, Yang, Li, Lin, Pingzhen   +4 more
openaire   +3 more sources

Patient‐Derived 3D‐Bioprinted Intrahepatic Cholangiocarcinoma Models Recapitulate Tumor Autologous Traits and Predict Personalized Adjuvant Therapy

Advanced Science, EarlyView.
Leveraging 3D bioprinting, this study establishes patient‐derived in vitro models of intrahepatic cholangiocarcinoma. These models faithfully recapitulate the histopathology, molecular profiles, and genomic characteristics of the original patient tumors.
Yuce Lu, Liwei Du, Minghao Sun, Kai Zhang, Mingchang Pang, Shangze Jiang, Jiaxun Dong, Xiyue Liu, Bao Jin, Fu Xu, Hang Sun, Jiangang Zhang, Huiyu Yang, Xiaobo Yang, Xin Lu, Yiyao Xu, Haitao Zhao, Shunda Du, Xinting Sang, Yongchang Zheng, Lei Zhang, Xueshuai Wan, Huayu Yang, Yilei Mao   +23 more
wiley   +1 more source

Adeno-Associated Virus-Mediated RNAi against Mutant Alleles Attenuates Abnormal Calvarial Phenotypes in an Apert Syndrome Mouse Model

Molecular Therapy: Nucleic Acids, 2018
Apert syndrome (AS), the most severe form of craniosynostosis, is caused by missense mutations including Pro253Arg(P253R) of fibroblast growth factor receptor 2 (FGFR2), which leads to enhanced FGF/FGFR2-signaling activity.
Fengtao Luo, Yangli Xie, Zuqiang Wang, Junlan Huang, Qiaoyan Tan, Xianding Sun, Fangfang Li, Can Li, Mi Liu, Dali Zhang, Meng Xu, Nan Su, Zhenhong Ni, Wanling Jiang, Jinhong Chang, Hangang Chen, Shuai Chen, Xiaoling Xu, Chuxia Deng, Zhugang Wang, Xiaolan Du, Lin Chen   +21 more
doaj   +1 more source

TNFα modulates Fibroblast Growth Factor Receptor 2 gene expression through the pRB/E2F1 pathway: identification of a non-canonical E2F binding motif. [PDF]

PLoS ONE, 2013
Interactions between epithelium and mesenchyme during wound healing are not fully understood, but Fibroblast Growth Factors (FGFs) and their receptors FGFRs are recognized as key elements.
Sirio D'Amici, Simona Ceccarelli, Enrica Vescarelli, Ferdinando Romano, Luigi Frati, Cinzia Marchese, Antonio Angeloni   +6 more
doaj   +1 more source

Circulating Tumor DNA Analysis Detects FGFR2 Amplification and Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced Gastric Cancer

Clinical Cancer Research, 2021
Purpose: FGFR2 amplification is associated with poor prognosis in advanced gastric cancer and its subclonal heterogeneity has been revealed. Here, we examined whether circulating tumor DNA (ctDNA) was useful for detecting FGFR2 amplification and co ...
Tomoko Jogo, Y. Nakamura, K. Shitara, H. Bando, H. Yasui, T. Esaki, T. Terazawa, T. Satoh, E. Shinozaki, T. Nishina, Y. Sunakawa, Y. Komatsu, H. Hara, E. Oki, N. Matsuhashi, T. Ohta, Takeshi Kato, K. Ohtsubo, T. Kawakami, N. Okano, Yoshiyuki Yamamoto, T. Yamada, A. Tsuji, J. Odegaard, H. Taniguchi, T. Doi, S. Fujii, T. Yoshino   +27 more
semanticscholar   +1 more source

A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science, EarlyView.
Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10+ phenotype that promotes angiogenesis and matrix ...
Mingming Yu, Xingxuan Zhang, Huan Zhang, Jun Wang, Fang Chen, Xiaojun Cai, Yichen Huang, Yuanyi Zheng   +7 more
wiley   +1 more source

532 Evaluating fibroblast growth factor receptor (FGFR) pathway mRNA expression and protein activation in cholangiocarcinoma tumors

Journal of Clinical and Translational Science
Objectives/Goals: Personalized cancer therapy based on genomic testing is advancing patient care. Genomic alterations in fibroblast growth factor receptor (FGFR) predict response to FGFR inhibitors; however, the role of RNA expression and protein ...
Leah Stein, Julie W. Reeser, Michele R. Wing, Eric Samorodnitsky, Anoosha Paruchuri, Amy Smith, Thuy Dao, Zachary Risch, Emanuel F. Petricoin, Sameek Roychowdhury   +9 more
doaj   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, EarlyView.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source