Results 101 to 110 of about 2,012 (174)

β-catenin dependent transcription mediates upregulation of Fgfr2b expression, which is inhibited in PR/8-infected, but not in non-infected lung epithelial cells.

, 2016
(A) EpCam+ lung epithelial cells derived from Rosa26ERTCre/ERTCre;Ctnnb1flox/flox mice were grown to confluency and treated with tamoxifen or DMSO control prior to infection with PR/8 (MOI = 0.1; 24h).
Jennifer Quantius (2836448), Saverio Bellusci (1874743), Elie El Agha (158281), Ludger Fink (5496), Susanne Herold (384252), Ana I. Vazquez-Armendariz (2836454), István Vadász (81952), Xiaokun Li (166455), Jochen Wilhelm (353946), Konstantin Mayer (2836457), Juergen Lohmeyer (180807), Werner Seeger (5494), Carole Schmoldt (2836451), Rory E. Morty (341515), Christin Becker (2836445), Stefan Gattenloehner (2836460), Mikhail Matrosovich (253583)   +16 more
core   +1 more source

FGFR2B Overexpression [PDF]

, 2020
openaire   +1 more source

FGFR signaling establishes spatial gradients of secretory cell identities along the airway proximal-distal axis

Nature Communications
Secretory cells are major structural and functional constituents of the lung airways. Their heterogeneity, spatial organization and specification mechanisms are partially understood.
Alexandros Sountoulidis, Jonas Theelke, Andreas Liontos, Alexandra B. Firsova, Orane Eliot, Janine Koepke, Pamela Millar-Büchner, Louise Mannerås-Holm, Åsa Björklund, Athanasios Fysikopoulos, Antonia Kelm, Eleni Bouloukou, Konstantin Gaengel, Fredrik Bäckhed, Christer Betsholtz, Werner Seeger, Saverio Bellusci, Christos Samakovlis   +17 more
doaj   +1 more source

Autophagy in human keratinocytes: role of the fibroblast growth factor receptor 2b and its signaling [PDF]

, 2017
Signaling of the epithelial splicing variant of the fibroblast growth factor receptor 2 (FGFR2b) induces both autophagy and phagocytosis in human keratinocytes.
NANNI, MONICA
core  

Health-related quality of life with bemarituzumab plus mFOLFOX6 in patients with FGFR2b-overexpressing, advanced gastric or gastroesophageal junction cancer

ESMO Gastrointestinal Oncology
Background: In the phase II, randomized, double-blind FIGHT trial (NCT03694522), treatment with bemarituzumab plus mFOLFOX6 resulted in improvements in progression-free survival and overall survival relative to mFOLFOX6 alone in previously untreated ...
Z.A. Wainberg, P.C. Enzinger, S. Qin, K. Yamaguchi, J. Wang, X. Zhou, A. Gnanasakthy, K. Taylor, A. Yusuf, I. Majer, A. Jamotte, Y.-K. Kang   +11 more
doaj   +1 more source

EpiSPC are resistant to apoptosis and show a high proliferative response after PR/8 infection which is mediated by Fgf10/Fgfr2b signaling.

, 2016
(A) Proliferation rates of the given epithelial cell subsets was analysed in PR/8 infected wt mice by FACS quantification of Ki67+ cells at the indicated time points pi.
Jennifer Quantius (2836448), Saverio Bellusci (1874743), Elie El Agha (158281), Ludger Fink (5496), Susanne Herold (384252), Ana I. Vazquez-Armendariz (2836454), István Vadász (81952), Xiaokun Li (166455), Jochen Wilhelm (353946), Konstantin Mayer (2836457), Juergen Lohmeyer (180807), Werner Seeger (5494), Carole Schmoldt (2836451), Rory E. Morty (341515), Christin Becker (2836445), Stefan Gattenloehner (2836460), Mikhail Matrosovich (253583)   +16 more
core   +1 more source

Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17

, 2020
The fibroblast growth factor receptor 2-IIIb (FGFR2b) and the vascular endothelial growth factor receptor 2 (VEGFR2) are tyrosine kinases that can promote cell migration and proliferation and have important roles in embryonic development and cancer. Here
Astrid Evers, Pui-Mun Wong, Karina Reiss, Steven L Swendeman, Thorsten Maretzky, Carl P Blobel, Wenhui Zhou, Shahin Rafii   +7 more
core  

Rôle de la voie de signalisation FGF10/FGFR2b lors du développement du tractus gastro-intestinal

, 2007
Le tube digestif est constitué de l œsophage, de l estomac, de l intestin grêle et du côlon. Une muqueuse spécifique leurs confère des rôles digestifs caractéristiques.
SALA, Frédéric, BELLUSCI, Savério
core  

Global prevalence of FGFR2b protein overexpression in advanced gastric cancer and gastroesophageal junction cancers: pooled analysis of two bemarituzumab phase III studies. [PDF]

ESMO Open
Maron SB, Xu RH, Wainberg ZA, Rha SY, Zhang Y, Pietrantonio F, Oliveira SCS, Li Y, Chen MH, Korphaisarn K, Elimova E, Calderon CA, Herpe FV, Yong WP, Dos Santos TM, Tan M, Isse K, Yanes RE, Shitara K.   +18 more
europepmc   +1 more source

Current and Emerging Targeted Therapy in Advanced Gastroesophageal Adenocarcinoma. [PDF]

Pharmaceuticals (Basel)
Oakley O, Mahmood U, Ahmad Y, Smyth E.
europepmc   +1 more source