Results 81 to 90 of about 2,012 (174)

LIF/LIFR Signaling in Gastric Cancer: A Double‐Edged Sword in Tumor Progression and Therapeutic Resistance

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Gastric cancer (GC) remains a major cause of cancer‐related mortality worldwide, driven by late‐stage diagnoses and poor survival outcomes. Leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) are increasingly recognized as critical players in GC pathophysiology, though their exact roles are not fully understood. LIF,
Daniel Park, Kyung‐Il Kim, Yate‐Ching Yuan, Pranati Shah, Hannah Zhong, Yu‐Han Chen, Sharity Ondrejik, Ellen Choi, Sofia Guzman, Vitor Goes, Christiana Crook, Wenqi Wang, Dani Ran Castillo, Daneng Li   +13 more
wiley   +1 more source

Research Progress on Embryonic Development, Genetic Regulation and Clinical Management of Congenital Middle Ear Malformations

Flavour and Fragrance Journal, Volume 40, Issue 3, Page 393-401, May 2025.
This article systematically reviews the embryonic development process and gene regulatory mechanisms of the middle ear, with a particular focus on the role of the Tbx1 gene, which is closely associated with middle ear development, in middle ear malformations, especially those involving the ossicular chain.
Xiaochen Gao, Chengzhilin Li, Fanyu Yuan, Xue Cao, Chengcheng Liu, Wenwen Qi, Fengyang Xie, Ming Xia   +7 more
wiley   +1 more source

Dynamics of soluble Fgfr2b expression and impact on AER maintenance after a single Dox-IP injection.

, 2013
(A) Embryos were collected at 0.5, 1,2,4,6,12 and 24 hrs after Dox IP at E11. (B) Schematic of the soluble Fgfr2b structure indicating the position of the specific primers P1 and P2 used to detect sFgfr2b expression.
Saverio Bellusci (1874743), Matthew Wheeler (475401), Xiaokun Li (166455), Sheryl Baptista (475400), Thomas Braun (269597), Guillermo Barreto (179056), Mohammad K. Hajihosseini (38987), Denise Al Alam (59722), Caterina Tiozzo (346568), Soula Danopoulos (346564), Gianni Carraro (38982), Sara Parsa (346562), Reza Tabatabai (475399)   +12 more
core   +1 more source

Combined KIT and FGFR2b Signaling Regulates Epithelial Progenitor Expansion during Organogenesis

Stem Cell Reports, 2013
Organ formation and regeneration require epithelial progenitor expansion to engineer, maintain, and repair the branched tissue architecture. Identifying the mechanisms that control progenitor expansion will inform therapeutic organ (re)generation.
Lombaert, Isabelle M.A., Abrams, Shaun R., Li, Li, Eswarakumar, Veraragavan P., Sethi, Aditya J., Witt, Robert L., Hoffman, Matthew P.   +6 more
openaire   +2 more sources

FGF20 Secreted From Dermal Papilla Cells Regulate the Proliferation and Differentiation of Hair Follicle Stem Cells in Fine‐Wool Sheep

Journal of Animal Physiology and Animal Nutrition, Volume 109, Issue 3, Page 655-666, MAY 2025.
ABSTRACT Wool traits determine the market value of fine‐wool sheep, and wool fibre‐breaking elongation (fibres can be stretched or elongated before they break) is one of the important wool traits. The interaction between hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs) determines hair follicle development in fine wool sheep, thereby ...
Yali Song, Yuhang Li, Zengkui Lu, Lin Yue, Tong Xiao, Bohui Yang, Jianbin Liu, Chao Yuan, Tingting Guo   +8 more
wiley   +1 more source

An Essential Requirement for Fgf10 in Pinna Extension Sheds Light on Auricle Defects in LADD Syndrome

Frontiers in Cell and Developmental Biology, 2020
The pinna (or auricle) is part of the external ear, acting to capture and funnel sound toward the middle ear. The pinna is defective in a number of craniofacial syndromes, including Lacrimo-auriculo-dento-digital (LADD) syndrome, which is caused by ...
Yang Zhang, Yang Zhang, Juan M. Fons, Mohammad K. Hajihosseini, Tianyu Zhang, Tianyu Zhang, Abigail S. Tucker   +6 more
doaj   +1 more source

Transforming Growth Factor Beta2 Promotes Migration and Inhibits the Proliferation of Gastric Cancer Cells by Regulating the pSmad2/3‐NDRG1 Signaling Pathway

MedComm, Volume 6, Issue 4, April 2025.
The binding of TGFβ2 to its cognate receptor triggers activation of the Smad2/3 signaling cascade. Following phosphorylation, Smad3 undergoes nuclear translocation where it specifically binds to the NDRG1 promoter region, facilitating transcriptional activation of this target gene.
Feng‐Jun He, Xiao‐Long Chen, Yun‐Feng Zhu, Hua‐Yang Pang, Ze‐Dong Li, Pan‐Ping Liang, Tao Jin, Zheng‐Wen Chen, Ze‐Hua Chen, Jian‐Kun Hu, Kun Yang   +10 more
wiley   +1 more source

Molecular Nodal Restaging Based on CEACAM5, FGFR2b and PTPN11 Expression Adds No Relevant Clinical Information in Resected Non-Small Cell Lung Cancer

, 2020
The relapse rate in non-small cell lung cancer (NSCLC) is high, even in localized disease, suggesting that the current approach to pathological staging is insufficiently sensitive to detect occult micrometastases present in resected lymph nodes ...
Pau Rodriguez-Taboada (9902516), Gemma Aiza (196696), Ivan Macia (9902504), Anna Ureña (9902510), Ernest Nadal (709876), Gabriel Capella (4504528), Samantha Aso (6389762), Ignacio Escobar (2591290), Francisco Rivas (1768414), Ricard Ramos (9902507), Carlos Deniz (9902519), Gabriela Rosado (9902513)   +11 more
core   +1 more source

Regulation of epithelial growth factor receptors by the oncoprotein E5 during the HPV16 differentiation-dependent life cycle

Tumour Virus Research
Human papillomavirus (HPV) 16 infection initiates upon viral entry into the basal cells of the epithelium. The virus manipulates signaling pathways to complete its life cycle, which depends on cellular differentiation.
Mariano A. Molina, Sneha Biswas, Omar Jiménez-Vázquez, Jason M. Bodily   +3 more
doaj   +1 more source

The septum transversum mesenchyme induces gall bladder development

Biology Open, 2013
Summary The liver, gall bladder, and ventral pancreas are formed from the posterior region of the ventral foregut. After hepatic induction, Sox17+/Pdx1+ pancreatobiliary common progenitor cells differentiate into Sox17+/Pdx1− gall bladder progenitors and
Yohei Saito, Takuya Kojima, Naoki Takahashi   +2 more
doaj   +1 more source