Figure 3 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
, 2023 FGFR kinase domain mutations detected at progression on FGFR inhibitors in urothelial cancer. A, Heat map representing individual patient data among the cohort of FGFR3-driven urothelial cancers. B–G, Molecular and radiologic findings.
Rastislav Bahleda (16617234) +21 more
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Understanding and Overcoming Resistance to Selective FGFR Inhibitors across FGFR2-Driven Malignancies. [PDF]
Clin Cancer ResInternational audienceUnderstanding resistance to selective FGFR inhibitors is crucial to improve the clinical outcomes of patients with FGFR2-driven malignancies. Experimental DesignWe analyzed sequential ctDNA, +/-WES or targeted NGS on tissue biopsies
Facchinetti F +19 more
europepmc +2 more sources
JTO Clinical and Research Reports, 2023 FGFR3-TACC3 fusions have been identified in patients with multiple cancer types, and tumors with these alterations are potentially sensitive to selective FGFR inhibitors. However, there are no FGFR inhibitors approved by the U.S.
Chi Pham, BSc +2 more
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Supplementary Table S3 from Facts and New Hopes on Selective FGFR Inhibitors in Solid Tumors
, 2020 Ongoing trials evaluating selective FGFR inhibitors in tumors harboring FGFR alterations.
Yohann Loriot (342267) +6 more
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The role of Memo in premature aging and FGFR signaling [PDF]
, 2012 Memo was recently identified in a screen for proteins required for ErbB receptor induced cell migration. Encoded by a single-copy gene present in all branches of life, it is ubiquitously expressed during all stages of embryogenesis and in adult tissues ...
Hänzi, Barbara
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Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer
The Journal of Clinical Investigation, 2023 Although subsets of patients with lung squamous cell carcinoma (LSCC) benefit from immunotherapy, there are few effective molecularly targeted treatments for LSCC.
Netta Mäkinen, Matthew Meyerson
doaj +1 more source
, 2021 Introduction: Fibroblast growth factor receptor (FGFR)/fibroblast growth factor (FGF) is a pathway characterized by recurring alterations in cancer.
Belli C. +5 more
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Discovery of Potent Irreversible Pan-Fibroblast Growth Factor Receptor (FGFR) Inhibitors
, 2018 Fibroblast growth factor receptors (FGFR1–4) are promising therapeutic targets in many cancers. With the resurgence of interest in irreversible inhibitors, efforts have been directed to the discovery of irreversible FGFR inhibitors.
Yang Dai (36730) +7 more
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Targeting the Fibroblast Growth Factor Receptor (FGFR) in Advanced Cholangiocarcinoma: Clinical Trial Progress and Future Considerations [PDF]
, 2021 Landmark molecular profiling efforts have identified multiple targetable alterations in cholangiocarcinoma. Among the molecular-driven subsets of cholangiocarcinoma, targeting the fibroblast growth factor receptor (FGFR) has shown promise and represents ...
Li, Daneng +11 more
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Figure 2 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
, 2023 Overview of patients with urothelial cancer progressing on FGFR inhibitors, treatment outcomes, and postprogression sample availability. Granular view at the individual patient level.
Rastislav Bahleda (16617234) +21 more
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