Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
BuildingsThis study explores the influence of the water–cement ratio and fiber content in engineered cementitious composite (ECC) on the mechanical characteristics of foamed lightweight soil (FLS) through experimental analysis. Two types of cementitious materials—
Qingguo Yang +5 more
doaj +1 more source
Processing and electrical characterization of a unidirectional CFRP composite filled with double walled carbon nanotubes [PDF]
, 2012 Carbon nanotubes represent new emergent multifunctional materials that have potential applications for structural and electrically conductive composites.
Bougherara, Habiba +3 more
core +4 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Civil Engineering DimensionThis research aimed at studying the effect of fiber content on the flexural strength and behavior of steel fiber reinforced concrete (SFRC) beams with steel rebars.
Ilham Nurhuda +3 more
doaj +1 more source
Random changes in the heifer rumen in bacterial community structure,physico-chemical and fermentation parameters, and in vitro fiber degradation [PDF]
, 2011 The variability over time of several main ruminal characteristics was studied in heifers over 15 consecutive weeks. Three heifers were assigned to a low-fiber diet (27% NDF) and three to a high-fiber diet (44% NDF).
Cauquil, Laurent +5 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Effects of Reinforcing Fiber Strength on Mechanical Properties of High-Strength Concrete
Fibers, 2019 This paper investigates the effects of the tensile strength of steel fiber on the mechanical properties of steel fiber-reinforced high-strength concrete.
Hyun-Do Yun +2 more
doaj +1 more source
Speciation without chromatography: Part I. Determination of tributyltin in aqueous samples by chloride generation, headspace solid-phase microextraction and inductively coupled plasma time of flight mass spectrometry [PDF]
, 2001 An analytical procedure was developed for the determination of tributyltin in aqueous samples. The relatively high volatility of the organometal halide species confers suitability for their headspace sampling from the vapour phase above natural waters or
Lam, J. +4 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source