Results 71 to 80 of about 9,961 (164)

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, Volume 13, Issue 14, 9 March 2026.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
Hager ElSheikh, Annika Salvers, Judith Piesker, Shenja Buchholz, Rabea Lange, Sabine Ameling, Leif Steil, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Frank U. Weiss, Matthias Sendler, Juliane Glaubitz   +13 more
wiley   +1 more source

Fibrillins in Adult Human Ovary and Polycystic Ovary Syndrome: Is Fibrillin-3 Affected in PCOS? [PDF]

Journal of Histochemistry & Cytochemistry, 2010
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. Although genetic linkage analyses have demonstrated a susceptibility locus for PCOS mapping to the fibrillin-3 gene, the presence of fibrillin proteins in normal and polycystic ovaries has not been characterized. This study compared and contrasted fibrillin-1, −2,
C Diana, Jordan, Sandra D, Bohling, Noe L, Charbonneau, Lynn Y, Sakai   +3 more
openaire   +2 more sources

Comparative Genomics of Pinna rudis and Pinna nobilis Reveals Conserved and Divergent Features of the Bivalve Defensome

Ecology and Evolution, Volume 16, Issue 3, March 2026.
We present the first high‐quality annotated genome of Pinna rudis and an updated genome assembly for Pinna nobilis, two Mediterranean fan mussel species differentially affected by mass mortality events. Comparative genomic analyses of gene sets associated with the “defensome” show that these genes are largely functionally conserved between the two ...
Stéphane Coupé, Mathieu Foulquié, Maite Vázquez Luis, Elvira Alvarez Perez, Jean‐Marc Prévot, Nardo Vicente, Robert Bunet   +6 more
wiley   +1 more source

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 2, Page 107-127, March 2026.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Dual Topical Therapy. The Future of Stretch Marks?

JEADV Clinical Practice, Volume 5, Issue 1, Page 26-31, March 2026.
ABSTRACT Striae distensae, or stretch marks, are linear scars that result from mechanical stretching of dermal tissue. They are most prevalent in women and in pregnancy, puberty, and obesity. The psychological and cosmetic symptoms may present a pathological synergy with the physical distress that stretch marks represent, especially if the patient is ...
Vicente Manuel Cisneros Rosell, Ramon Grimalt   +1 more
wiley   +1 more source

ADAR1 Is Essential for Smooth Muscle Homeostasis and Vascular Integrity

Cells
Vascular smooth muscle cells (VSMCs) play a critical role in maintaining vascular integrity. VSMC dysfunction leads to numerous vascular diseases. Adenosine deaminases acting on RNA 1 (ADAR1), an RNA editing enzyme, has shown both RNA editing and non ...
Dunpeng Cai, Shi-You Chen
doaj   +1 more source

Persistent great artery dilatation in Beals syndrome: A novel finding

Annals of Pediatric Cardiology, 2019
We report a unique case of dilated aortic root and pulmonary artery in an infant with clinical features consistent with Beals syndrome confirmed to have fibrillin-2 mutation.
Saira Siddiqui, Laurie Panesar
doaj   +1 more source

Proteome‐Wide Analysis of Human Deletions

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 3, Page 853-870, March 2026.
ABSTRACT Protein deletions are frequent among both natural and pathogenic variations. Many of them are misclassified in variation databases and the literature. Nonsense‐mediated decay prevents the expression of many nucleotide deletions. Many variants classified as protein deletions are not expressed at all.
Haoyang Zhang, Xinning Luan, Mauno Vihinen   +2 more
wiley   +1 more source

P10.05 REDUCED MOLECULAR FLEXIBILITY IN THE LARGE ARTERIES OF DIABETIC RATS

Artery Research, 2009
In Type 1 and 2 diabetes tissue stiffening is evident from measurements of the gross mechanical properties of the vasculature. In general, pathological glycosylation of extracellular matrix proteins may play an important role in increasing stiffness in ...
R. Akhtar, N. Gardiner, J.K. Cruickshank, B. Derby, M.J. Sherratt   +4 more
doaj   +1 more source

Plasma Proteomic Signatures of Pediatric Sepsis Reveal Persistent Inflammation and Phase‐Specific Biomarkers

FASEB BioAdvances, Volume 8, Issue 3, March 2026.
We enrolled a pediatric sepsis cohort at acute and recovery phases for plasma proteomics analysis. Abundantly expressed proteins in sepsis were identified and subjected to machine learning. In addition, the data was compared to adult sepsis and sterile inflammation.
Fahd Alhamdan, Yi‐Cheng Sin, Erik Malm, Hanna Van Pelt, Samuel Kim, LeeAnn Higgins, Yue Chen, Koichi Yuki   +7 more
wiley   +1 more source