Results 51 to 60 of about 199,538 (306)

Ex vivo engineering of blood and lymphatic microvascular networks

Vascular Biology, 2019
Despite tremendous efforts in preclinical research over the last decades, the clinical translation of therapeutic angiogenesis to grow stable and functional blood vessels in patients with ischemic diseases continues to prove challenging.
Jaana Schneider, Marianne Pultar, Wolfgang Holnthoner   +2 more
doaj   +1 more source

Global coagulation assays in patients with diabetes mellitus

Research and Practice in Thrombosis and Haemostasis, 2021
Background There is significant heterogeneity in the incidence and severity of diabetes‐associated vascular complications and there is no routine biomarker that accurately predicts these outcomes.
Hui Yin Lim, Brandon Lui, Mark Tacey, Anna Kwok, Suresh Varadarajan, Geoffrey Donnan, Harshal Nandurkar, Prahlad Ho   +7 more
doaj   +1 more source

Fibrin-Targeted Polymerized Shell Microbubbles as Potential Theranostic Agents for Surgical Adhesions

, 2019
The development of new therapies for surgical adhesions has proven to be difficult as there is no consistently effective way to assess treatment efficacy in clinical trials without performing a second surgery, which can result in additional adhesions. We
Jo Ann Buczek-Thomas (366939), Catherine A. Gormley (6315497), Amanda C. S. N. Pessoa (6315503), Fabrice Monti (2106919), Catherine A. Gormley, Joyce Y. Wong (2092636), Jiang Xu, Fabrice Monti, R. Glynn Holt, Joyce Y. Wong, Jiang Xu (351121), Jon O. Nagy (2109607), Amanda C. S. N. Pessoa, Benjamin J. Keenan, R. Glynn Holt (3336738), Patrick Tabeling (2106913), Benjamin J. Keenan (6315500), Jon O. Nagy, Jo Ann Buczek-Thomas, Patrick Tabeling   +19 more
core   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure

Platelets, 2023
Statins inhibit the mevalonate pathway by impairing protein prenylation via depletion of lipid geranylgeranyl diphosphate (GGPP). Rab27b and Rap1a are small GTPase proteins involved in dense granule secretion, platelet activation, and regulation.
Mohammed M Jalal, Claire S Whyte, Fraser P Coxon, Nicola J Mutch   +3 more
doaj   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Resonance-thrombography indices of the haemostatic process in relation to risk of incident coronary heart disease: 9 years follow-up in the Caerphilly Prospective Heart Disease Study [PDF]

, 2004
Global assays, such as resonance-thrombography (RTG), which measure the interaction between platelets, coagulation and fibrinolysis have been used as summary measures of risk for over two decades but have not been evaluated in epidemiological studies. We
Lowe, G.D.O., Yarnell, J.W.G., Yu, S.C., Sweetnam, P.M.   +3 more
core   +1 more source

Effects of Fibrin Glue, 2-Octyl Cyanoacrylate, and N-Butyl Cyanoacrylate on Cartilage Healing: An Experimental Animal Study [PDF]

, 2021
Aim:Following septoplasty surgery, nasal packing is performed to stabilize the healing of septum and prevent septal hematoma. The purpose of this study was to investigate the efficacy of fibrin glue, 2-octyl cyanoacrylate, and n-butyl cyanoacrylate on ...
Berk Gurpinar, Uyar, Yavuz, Huseyin Altun, Hanci, Deniz, Yavuz Uyar, Zeybek, Dilara, Gurpinar, Berk, Altun, Huseyin, Dilara Zeybek, Deniz Hanci, Onur Ustun, Ustun, Onur   +11 more
core   +1 more source

Copolymers of Poly(Butylene Trans‐1,4‐Cyclohexanedicarboxylate)/Pripol as New Biomaterial Platform for Small Diameter Vascular Graft

Advanced Healthcare Materials, EarlyView.
Electrospun tubular scaffolds from novel PBCE‐based copolyesters and blends were designed as candidates for small‐diameter vascular grafts. They combine defect‐free architecture, blood‐compatible surfaces, and mechanical properties comparable to native vessels.
Edoardo Bondi, Gabriele Obino, Giulia Guidotti, Alberto Sensini, Martijn van Griensven, Antonio Junior Lepedda, Nadia Lotti, Lorenzo Moroni   +7 more
wiley   +1 more source