Results 61 to 70 of about 374,474 (339)

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

Impaired endogenous fibrinolysis at high shear using a point-of-care test in STEMI is associated with alterations in clot architecture [PDF]

, 2019
© The Author(s) 2019Impaired endogenous fibrinolysis is an adverse prognostic biomarker in acute coronary syndrome (ACS). Abnormally dense in vitro fibrin thrombi have been demonstrated in ACS patients and related to hypofibrinolysis using cumbersome ...
A Undas, Anwar Baydoun, C Christopoulos, DB Cines, Diana A. Gorog, Guogang Ren, Manivannan Srinivasan, Mohamed Farag, Nikolaos Spinthakis, ON Okafor, S Saraf, W Sumaya, Ying Gue   +12 more
core   +3 more sources

Precise Quantification of Angiogenesis in 3D Biomaterials Using in Vitro CAM Models: Enhancing 3Rs in Research and Minimizing in Vivo Dependency

Advanced Functional Materials, EarlyView.
The study develops elastin–fibrin scaffolds and evaluates angiogenesis using the chorioallantoic membrane (CAM) model. Advanced imaging with confocal microscopy and Indocyanine Green dye enables precise 3D quantification of vascular networks. Findings demonstrate superior microvessel visualization compared to micro‐CT using Microfil and Optiray 350 ...
Ece Melis Er, Martha Patricia Pérez González, Beatriz Gil Garrido, Jasmine Ho, Hae‐Won Kim, Jonathan Campbell Knowles, Jia Hua, Ferdinand Lali, Prasad Sawadkar   +8 more
wiley   +1 more source

Segmentation, Reconstruction, and Analysis of Blood Thrombus Formation in 3D 2-Photon Microscopy Images [PDF]

, 2009
We study the problem of segmenting, reconstructing, and analyzing the structure growth of thrombi (clots) in blood vessels in vivo based on 2-photon microscopic image data.
Alber, Mark S., Chen, Danny Z., Kamocka, Malgorzata M., Liu, Xiaomin, Mu, Jian, Rosen, Elliot D., Xu, Zhiliang   +6 more
core   +2 more sources

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source

Ex vivo engineering of blood and lymphatic microvascular networks

Vascular Biology, 2019
Despite tremendous efforts in preclinical research over the last decades, the clinical translation of therapeutic angiogenesis to grow stable and functional blood vessels in patients with ischemic diseases continues to prove challenging.
Jaana Schneider, Marianne Pultar, Wolfgang Holnthoner   +2 more
doaj   +1 more source

Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. [PDF]

, 2013
Background Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate [CS] and dermatan sulfate [DS]) and expose extracellular matrix (ECM) proteins (e.g.
Bóta, Attila, Kolev, K., Komorowicz, E., Longstaff, C., Machovich, R., Rottenberger, Z., Szabó, László, Varga, Zoltán   +7 more
core   +1 more source

Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation

Scientific Reports, 2019
Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid protein of Alzheimer’s disease ...
M. Page, G. Thomson, J. M. Nunes, A. Engelbrecht, T. Nell, W. D. de Villiers, M. de Beer, L. Engelbrecht, D. Kell, E. Pretorius   +9 more
semanticscholar   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Global coagulation assays in patients with diabetes mellitus

Research and Practice in Thrombosis and Haemostasis, 2021
Background There is significant heterogeneity in the incidence and severity of diabetes‐associated vascular complications and there is no routine biomarker that accurately predicts these outcomes.
Hui Yin Lim, Brandon Lui, Mark Tacey, Anna Kwok, Suresh Varadarajan, Geoffrey Donnan, Harshal Nandurkar, Prahlad Ho   +7 more
doaj   +1 more source