Results 121 to 130 of about 16,509 (247)

The role of fibrinogen and fibrinogen concentrate in cardiac surgery: an international consensus statement from the Haemostasis and Transfusion Scientific Subcommittee of the European Association of Cardiothoracic Anaesthesiology.

, 2019
To date, data regarding the efficacy and safety of administering fibrinogen concentrate in cardiac surgery are limited. Studies are limited by their low sample size and large heterogeneity with regard to the patient population, by the timing of ...
Meesters, M. I., Ravn, H B, E. Baryshnikova, M. Ranucci, Ranucci, M, Koster, A., Erdoes, G., Ravn, H. B., Ranucci, M., G. Erdoes, Agarwal, S, Bolliger, D., M. I. Meesters, M. D. Lance, Lance, M D, Agarwal, S., Ortmann, E., H. B. Ravn, D. Bolliger, C. von Heymann, von Heymann, C., S. Agarwal, Meesters, M I, E. Ortmann, Koster, A, A. Koster, von Heymann, C, Erdös, Gabor, Ortmann, E, Ahmed, A., Bolliger, D, A. Ahmed, Ahmed, A, Lance, M. D., Baryshnikova, E, Baryshnikova, E.   +35 more
core   +1 more source

Hematologic complications in vascular malformations: A case study of 2 patients

Journal of Education, Health and Sport
Vascular malformations are congenital vascular anomalies resulting from a disruption in the vasculogenesis process. (1)  They are congenital changes that enlarge as the child develops and do not undergo spontaneous involution.
Iwona Matus, Kaja Bator, Weronika Machaj, Aleksandra Krzemienowska-Cebulla, Mateusz Dorochowicz, Hanna Senat, Adrian Korbecki, Andrzej Szuba, Maciej Rabczyński   +8 more
doaj   +1 more source

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, Volume 183, Issue 15, Page 4111-4125, August 2026.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Combining Supramolecular and Covalent Chemistry to Form Reinforced Fibrillar Network Hydrogels From Fibrinogen Derivatives

Journal of Biomedical Materials Research Part A, Volume 114, Issue 7, July 2026.
ABSTRACT Fibrin hydrogels provide a highly supportive environment for three‐dimensional cell growth and morphogenesis but are limited by insufficient stability to maintain their shape and mechanical integrity. To address this limitation, we developed a reinforced fibrin hydrogel incorporating photo‐crosslinked methacrylated fibrinogen (FibMA).
Noa Notea‐Debutton, Haneen Simaan‐Yameen, Dror Seliktar   +2 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Factors influencing antithrombin activity following supplementation in sepsis-associated disseminated intravascular coagulation

Thrombosis Journal
Background Antithrombin, a key regulator of the coagulation cascade, is often decreased in patients with sepsis-associated disseminated intravascular coagulation (DIC).
Tomoki Tanigawa, Toshiaki Iba, Cheryl L. Maier, Ecaterina Scarlatescu, Yutaka Kondo, Hideo Wada, Jerrold H. Levy   +6 more
doaj   +1 more source

Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment

The FEBS Journal, Volume 293, Issue 13, Page 4085-4097, July 2026.
MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley   +1 more source

Impaired EDRF production by endothelial cells exposed to fibrin monomer and FDP

, 1995
Fibrin and fibrinogen and their proteolytic degradation products, found within the atheroma, may contribute to vascular dysfunction. We monitored the production of endothelium-derived relaxing factor (EDRF) by bovine aortic endothelial cells (BAEC ...
A. Fabian, J. Loscalzo, J. E. Freedman
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source