Abstract Precise, reproducible quantitation of fibrinogen from plasma using thrombin to convert it to fibrin requires careful attention to the technics of clot formation and syneresis. The precision of the method outlined indicates a coefficient of variation of 1.2% with replicate samples.
W R, Swaim, M B, Feders
openaire +2 more sources
Fibrinogen is the major plasma protein coagulation factor. Low plasma fibrinogen concentrations are therefore associated with an increased risk of bleeding due to impaired primary and secondary haemostasis. Fibrinogen is a classical positive acute-phase reactant protein and is an independent predictor of coronary heart disease events.
Gordon D O, Lowe +2 more
openaire +2 more sources
Blood rheology, cardiovascular risk factors, and cardiovascular disease: The West of Scotland Coronary Prevention Study [PDF]
The West of Scotland Coronary Prevention Study (WOSCOPS) showed that pravastatin reduced the risk of coronary heart disease (CHD) events in 6,595 middle-aged hypercholesterolaemic men aged 45-64 years without prior myocardial infarction followed for an ...
Ann Rumley +8 more
core +1 more source
This study evaluated whether rotational thromboelastometry (ROTEM; Tem International GmbH, Munich, Germany) FIBTEM maximum clot firmness (MCF) can be used to predict plasma fibrinogen level in pediatric patients undergoing cardiac surgery.
Christopher F. Tirotta MD, MBA +10 more
doaj +1 more source
Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral NG-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor.
Yasutaka Takinishi +2 more
doaj +1 more source
Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B. +12 more
core +1 more source
Young girl with congenital hypo-dysfibrogenemia presenting with an acute subdural haemorrhage
Fibrinogen plays a pivotal role in the coagulation cascade. Inherited fibrinogen disorders are a heterogenous group that includes lack or reduced fibrinogen levels or a qualitative disorder of fibrinogen, dysfibrinogenemia.
I. N. Walmsley +3 more
doaj +1 more source
Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season [PDF]
Background and Objective Air temperature changes are associated with increased cardiovascular and respiratory risk, but the roles of inflammatory and coagulation markers are not well understood.
Breitner, Susanne +8 more
core +1 more source
Short-Chained Oligo(Ethylene Oxide)-Functionalized Gold Nanoparticles: Realization Of Significant Protein Resistance [PDF]
Protein corona formed on nanomaterial surfaces play an important role in the bioavailability and cellular uptake of nanomaterials. Modification of surfaces with oligoethylene glycols (OEG) are a common way to improve the resistivity of nanomaterials to ...
Riley, Kathryn R. +4 more
core +2 more sources
Fibrinogen replacement therapy for congenital fibrinogen deficiency [PDF]
This review of published studies was conducted to derive data on patients with congenital fibrinogen deficiency (CFD), including dosing of fibrinogen replacement therapy, outcome, and adverse events, either temporally related or distant to fibrinogen replacement, in order to assist clinicians in developing treatment plans for patients with CFD.
L, Bornikova +4 more
openaire +2 more sources

