Combating ageing beyond the cell: Emerging roles of extracellular proteostasis
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh +7 more
wiley +1 more source
Beyond Rebalanced Haemostasis: Haemostatic Phenotypes, Thrombin Generation, and Clinical Risk in Chronic Liver Disease. [PDF]
Agouba SM +9 more
europepmc +1 more source
ABSTRACT Post‐translational modifications (PTMs) of proteins are essential to maintain homeostasis as many cellular processes rely on reversible PTMs. However, several PTMs, particularly irreversible PTMs in the extracellular space, can contribute to tissue dysfunction, inflammation, and may even trigger the development of autoimmunity against PTM ...
Marleen M. J. van Greevenbroek +1 more
wiley +1 more source
Reconsidering the default: should surgical pulmonary embolectomy have a larger role in high-risk pulmonary embolism at experienced centres? [PDF]
Khashkhusha A +3 more
europepmc +1 more source
Predictive Value of D‐Dimer to Albumin Ratio for Outcome in Acute Type A Aortic Dissection Patients
ABSTRACT Preoperative risk assessment and identification of potential biomarkers may optimize prognostic outcomes in patients with aortic dissection patients. The relationship between the D‐dimer to albumin ratio (DAR), an emerging biomarker that has recently attracted increasing attention, and postoperative outcomes in patients with acute type A ...
Aijie Lin +4 more
wiley +1 more source
PROS1 Cys475Tyr mutation associated with a type III protein S deficiency pattern. [PDF]
Mejias-Figueroa JA +2 more
europepmc +1 more source
MAFLD/MASLD: Past, Present, and Future
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD), also known as nonalcoholic fatty liver disease and metabolic dysfunction‐associated fatty liver disease, affects more than 30% of the global adult population and has become one of the leading causes of cirrhosis and hepatocellular carcinoma.
Vincent Wai‐Sun Wong
wiley +1 more source
Emerging strategies in venous thromboembolism: a narrative review of pharmacological innovations. [PDF]
Ye J, Huang K.
europepmc +1 more source
An Exploratory Pilot Study of Coagulation- and Fibrinolysis-Related Proteins in Unexplained Infertility. [PDF]
Nandakumar M +4 more
europepmc +1 more source

