Results 51 to 60 of about 80,628 (257)

A historical review of experimental imaging of the beating heart coronary microcirculation in vivo

Journal of Anatomy, Volume 242, Issue 1, Page 3-16, January 2023., 2023
Intravital imaging of the beating heart microcirculation in vivo has been challenging. The past 50 years has seen changes in ways to both stabilise and image the heart with a shift from learning about coronary vascular anatomy and physiology to the role of thromboinflammation and other microcirculatory disturbances in cardiovascular disease.
Neena Kalia
wiley   +1 more source

Disorder of Coagulation-Fibrinolysis System: An Emerging Toxicity of Anti-PD-1/PD-L1 Monoclonal Antibodies

Journal of Clinical Medicine, 2019
A disruption of immune checkpoints leads to imbalances in immune homeostasis, resulting in immune-related adverse events. Recent case studies have suggested the association between immune checkpoint inhibitors (ICIs) and the disorders of the coagulation ...
R. Sato, K. Imamura, S. Sakata, T. Ikeda, Y. Horio, S. Iyama, K. Akaike, S. Hamada, T. Jodai, K. Nakashima, Shiho Ishizuka, Nahoko Sato, K. Saruwatari, S. Saeki, Y. Tomita, T. Sakagami   +15 more
semanticscholar   +1 more source

Recognition of plasminogen activator inhibitor type 1 as the primary regulator of fibrinolysis.

Current Drug Targets, 2019
The fibrinolytic system is composed of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms.
T. Urano, Yuko Suzuki, T. Iwaki, H. Sano, N. Honkura, F. Castellino   +5 more
semanticscholar   +1 more source

7.5% NaCl Resuscitation Leads to Abnormal Clot Fibrinolysis after Severe Hemorrhagic Shock and its Correction with 7.5% NaCl Adenosine, Lidocaine, and Mg2+

Journal of Emergencies, Trauma and Shock, 2018
Background: Hyperfibrinolysis is a common complication of hemorrhagic shock. Our aim was to examine the effect of small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ (ALM) on fibrinolysis in the rat model of hemorrhagic shock.
Hayley Louise Letson, Geoffrey Phillip Dobson   +1 more
doaj   +1 more source

16-year follow-up of the Danish Acute Myocardial Infarction 2 (DANAMI-2) trial: primary percutaneous coronary intervention vs. fibrinolysis in ST-segment elevation myocardial infarction.

European Heart Journal, 2019
AIMS The DANish Acute Myocardial Infarction 2 (DANAMI-2) trial found that interhospital transport to primary percutaneous coronary intervention (pPCI) was superior to fibrinolysis at the local hospital in patients with ST-segment elevation myocardial ...
P. Thrane, S. Kristensen, K. Olesen, L. S. Mortensen, H. Bøtker, L. Thuesen, H. Hansen, U. Abildgaard, T. Engstrøm, H. Andersen, M. Maeng   +10 more
semanticscholar   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Endogenous fibrinolysis inhibitors in acute coronary syndrome

American Heart Journal Plus, 2021
Patients with acute coronary syndrome have a high residual risk of ischemic events despite current treatment methods, both invasive and antithrombotic strategies. The strategy of very early revascularization although has been suggested to improve patient
Baskaran Chandrasekar
doaj  

Harmful or Physiologic: Diagnosing Fibrinolysis Shutdown in a Trauma Cohort With Rotational Thromboelastometry

Anesthesia and Analgesia, 2018
BACKGROUND: Despite its central role in early trauma coagulopathy, abnormal fibrinolysis continues to be poorly understood. Excessive fibrinolysis is a known contributor to mortality.
J. C. Gomez-Builes, Sergio A. Acuna, Bartolomeu Nascimento, F. Madotto, Sandro Rizoli   +4 more
semanticscholar   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Frameless CT-navigation and local fibrinolysis in surgery of non-traumatic deep intracerebral hemorrhages

Ukrainian Neurosurgical Journal, 2010
The initial experience of Stealth Station® TREON®Plus navigation system (Medtronic, USA) and local fibrinolysis with aktilyze during operation because of primary non-traumatic deep intracranial hemorrhages was analyzed.
N. A. Zorin, S. P. Grigoruk, A. G. Sirko, D. V. Garus, I. E. Plyushshev   +4 more
doaj   +1 more source