Results 181 to 190 of about 24,815 (217)

Pharmacology of fibrinolytic agents

Progress in Cardiovascular Diseases, 1979
T HE appreciation of the high morbidity and mortality from thromboembolic occlusive vascular disease has given the impetus to a continuing search for drugs that might be of clinical value in its prevention and treatment. Anticoagulant therapy with heparin or the oral anticoagulants is primarily prophylactic, and while these drugs can prevent the ...
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The clinical use of fibrinolytic agents

The American Journal of Surgery, 1977
Two fibrinolytic drugs, streptokinase and urokinase, have undergone extensive clinical evaluation in the past fifteen years. Current evidence suggests that these agents may become the drugs of choice in the treatment of certain patients with venous thrombosis and pulmonary embolism.
J M, Porter, S H, Goodnight
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Tenecteplase: A fibrinolytic agent

British Journal of Cardiac Nursing, 2006
Thrombolysis is an established therapy for acute myocardial infarction in the UK. ST-elevation myocardial infarction almost always occurs owing to coronary atherosclerosis and coronary thrombosis which develops because of plaque disruption. Fibrinolytic agents act to dissolve the clot.
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Antibody-Directed Urokinase: A Specific Fibrinolytic Agent

Science, 1985
A specific fibrinolytic agent was synthesized by covalently coupling urokinase to a monoclonal antibody that was fibrin-specific and did not cross-react with fibrinogen. The antibody was raised against a synthetic peptide representing the seven amino-terminal residues of the beta chain of human fibrin.
C, Bode, G R, Matsueda, K Y, Hui, E, Haber   +3 more
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Indirect Fibrinolytic Agents

1978
The prophylaxis and treatment of thromboembolic disorders have long involved the use of anticoagulants administered either parenterally or via the oral route. However, at the present time, there is no longer unanimity regarding the effectiveness of this medication, due to the difficulties of objective assessment of all of the parameters of ...
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ROLE OF FIBRINOLYTIC AGENTS IN THROMBOTIC DISEASES

Journal of the American Medical Association, 1960
Critical analysis of existing data demonstrates that fibrinolysin in conjunction with anticoagulant therapy decreases the morbidity in patients with thrombophlebitis. This conclusion was the result of comparison of data from hospital charts of 20 patients in a fibrinolysin-treated series and a control group of 22 patients. The comparison was made after
R V, CHAPPLE, H O, SINGHER
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Fibrinolytic Agents: Mechanisms of Activity and Pharmacology

Thrombosis and Haemostasis, 1995
Fibrinolytic (thrombolytic) agents activate the fibrinolytic system by conversion of the inactive proenzyme, plasminogen into the active enzyme plasmin, that degrades fibrin. Agents available for clinical use are: the physiologic tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA)--either in a single chain (scu-PA ...
H R, Lijnen, D, Collen
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[Non-enzymatic fibrinolytic agents].

Annales de l'anesthesiologie francaise, 1979
Non-enzyme fibrinolytic agents include pharmacological agents which are active in vivo but inactive in vitro and synthetic chemical compounds which when added to blood or plasma in vitro directly induce fibrinolysis. There are a number of drugs with a short duration of action such as adrenalin, nicotinic acid, vasopressin and histamine.
I M, Nilsson, U, Hedner
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Acyl-Enzymes As Fibrinolytic Agents

Thrombosis and Haemostasis, 1981
Plasminogen activators or plasmins specifically and reversibly acylated at the active centre have been used as delivery systems for fibrinolytic agents in vivo. Potential advantages of this approach, including enhanced efficacy, reduced toxicity and better control of lysis are discussed.
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Comparison of Caseinolytic and Fibrinolytic Assays for Plasmin (Fibrinolysin) in “Fibrinolytic Agents”

Thrombosis and Haemostasis, 1966
Summary1. Caseinolytic and fibrinolytic systems for assay of plasmin in fibrinolytic agents are described which are based upon the determinations of AE/min during the linear portion of the casein-plasmin and fibrin-plasmin reaction curves respectively. A " caseinolytic-rate " unit and “fibrinolytic-rate " unit of ÄE/min × 103 during the linear portion ...
K M, Moser, M B, Frey
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