Results 11 to 20 of about 25,198 (264)

Purification and Characterization of a Fibrinolytic Enzyme from Marine Bacillus velezensis Z01 and Assessment of Its Therapeutic Efficacy In Vivo

Microorganisms, 2022
Fibrinolytic enzymes are the most effective agents for the treatment of thrombotic diseases. In the present study, we purified and characterized an extracellular fibrinolytic serine metalloprotease (named Velefibrinase) that is produced by marine ...
Yuting Zhou, Huizhen Chen, Bo Yu, Guiguang Chen, Zhiqun Liang   +4 more
doaj   +1 more source

Efficiency of regional catheter-guided thrombolysis in treatment of late total and subtotal deep vein thrombosis

Вестник хирургии имени И.И. Грекова, 2020
The  OBJECTIVE   was   to  assess the  effectiveness  of  the  developed  method  for  treating   DVT  with  fibrinolytic agent injection  via  a  catheter with  multiple  openings along  the  length  of  entire  thrombus.METHODS  AND MATERIALS.
B. S. Sukovatykh, A. V. Sereditsky, V. F. Muradyan, A. M. Azarov, M. B. Sukovatykh, A. R. Khachatryan, A. A. Lapinas   +6 more
doaj   +1 more source

Screening of a Novel Fibrinolytic Enzyme-Producing Streptomyces from a Hyper-Arid Area and Optimization of Its Fibrinolytic Enzyme Production

Fermentation, 2023
Fibrinolytic enzymes are a kind of proteolytic enzymes that can hydrolyze fibrin and dissolve blood clots. They could be used as a therapeutic agent for treating thrombosis.
Zixuan He, Yang Sun, Min Chu, Jing Zhu, Yu Zhang, Qiyong Tang, Ghenijan Osman, Ling Jiang, Zhidong Zhang   +8 more
doaj   +1 more source

Synthesis and Bioactivities of Marine Pyran-Isoindolone Derivatives as Potential Antithrombotic Agents

Marine Drugs, 2021
2,5-Bis-[8-(4,8-dimethyl-nona-3,7-dienyl)-5,7-dihydroxy-8-methyl-3-keto-1,2,7,8-teraahydro-6H-pyran[a]isoindol-2-yl]-pentanoic acid (FGFC1) is a marine pyran-isoindolone derivative isolated from a rare marine microorganism Stachybotrys longispora FG216 ...
Yinan Wang, Hui Chen, Ruilong Sheng, Zhe Fu, Junting Fan, Wenhui Wu, Qidong Tu, Ruihua Guo   +7 more
doaj   +1 more source

Fibrin and Fibrinolytic Enzyme Cascade in Thrombosis: Unravelling the Role

Life, 2023
Blood clot formation in blood vessels (thrombosis) is a major cause of life-threatening cardiovascular diseases. These clots are formed by αA-, βB-, and ϒ-peptide chains of fibrinogen joined together by isopeptide bonds with the help of blood coagulation
Rajni Singh, Prerna Gautam, Chhavi Sharma, Alexander Osmolovskiy   +3 more
doaj   +1 more source

A Novel Marine Pyran-Isoindolone Compound Enhances Fibrin Lysis Mediated by Single-Chain Urokinase-Type Plasminogen Activator

Marine Drugs, 2022
Fungi fibrinolytic compound 1 (FGFC1) is a rare pyran-isoindolone derivative with fibrinolytic activity. The aim of this study was to further determine the effect of FGFC1 on fibrin clots lysis in vitro.
Chunli Gao, Simin Tang, Haixing Zhang, Huishu Zhang, Tian Zhang, Bin Bao, Yuping Zhu, Wenhui Wu   +7 more
doaj   +1 more source

Bioconversion of agro-industrial wastes for the production of fibrinolytic enzyme from Bacillus halodurans IND18: Purification and biochemical characterization

Electronic Journal of Biotechnology, 2016
Background: Agro-wastes were used for the production of fibrinolytic enzyme in solid-state fermentation. The process parameters were optimized to enhance the production of fibrinolytic enzyme from Bacillus halodurans IND18 by statistical approach.
Ponnuswamy Vijayaraghavan, Samuel Gnana Prakash Vincent, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi   +3 more
doaj   +1 more source

Histomorphometric analysis of the lung of Swiss mice treated with a fibrinolytic protease

Anais da Academia Brasileira de Ciências, 2022
Fibrinolytic enzymes are considered promising alternative in the treatment of cardiovascular diseases by preventing fibrin clots. A protease from Mucor subtilissimus UCP 1262 was obtained by solid state fermentation and purified by ion exchange ...
MARLLYN M. DA SILVA, MARIA A.C. DE LIRA, TAMIRIS A. ROCHA, DANIELLE F. DE MOURA, FRANCISCO C.A.A. JÚNIOR, ANA V.S. FERREIRA, LORENZO PASTRANA, WENDELL W.C. ALBUQUERQUE, ROMERO M.P.B. COSTA, THIAGO P. NASCIMENTO, ANA L.F. PORTO   +10 more
doaj   +1 more source

Spectrophotometric analysis of thrombolytic activity: SATA assay [PDF]

, 2017
Introduction: Measurement of thrombolytic activity i.e. clot lysis is crucial for research and development of novel thrombolytics. It is also a key factor in assessment of the effectiveness of conventionally used thrombolytic agents in the clinic, which ...
Entekhabi, Nazila, Eskandani, Morteza, Farhoudi, Mehdi, Mohammadian, Reza, Rafi, Mohammad, Zamanlu, Masumeh   +5 more
core   +2 more sources

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]

, 2018
© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast, AD Michelson, B Labarthe, B Shen, C Patrono, CT Ammollo, D Capodanno, D Gailani, DA Gorog, Diana A. Gorog, DM Coenen, E Álvarez, ER Bates, F Kabirian, F Müller, F Semeraro, G Stephens, H Brogren, HE Speich, HE Speich, HJ Weiss, HJ Weiss, HR Baumgartner, J Zilberman-Rudenko, JD McFadyen, JI Weitz, JM Cosemans, JP Collet, JP Collet, K Hosokawa, K Nagatsuka, KS Sakariassen, L Valerio, LF Brass, M Cattaneo, M Farag, M Humbert, M Larsson, M Li, M Ungerer, MA Bailey, MI Furman, MJ Price, ML Montfoort von, MS Sabatine, P Andre, P Seizer, PA Borne von dem, PP Wadowski, R Hellmuth, R Nergiz-Unal, RA Ajjan, S Goto, S Goto, SA Shaya, SB Larsen, SJ Marciniak, T Heitzer, T Renné, VT Turitto, VT Turitto, WA Schumacher, WS Nesbitt, X Wang, Y Yano, YC Lau, ZM Ruggeri   +66 more
core   +2 more sources