Results 191 to 200 of about 3,180,492 (237)
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Thrombosis and Haemostasis, 1966
Summary1. Caseinolytic and fibrinolytic systems for assay of plasmin in fibrinolytic agents are described which are based upon the determinations of AE/min during the linear portion of the casein-plasmin and fibrin-plasmin reaction curves respectively. A " caseinolytic-rate " unit and “fibrinolytic-rate " unit of ÄE/min × 103 during the linear portion ...
Mary Belle Frey, K. M Moser
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Summary1. Caseinolytic and fibrinolytic systems for assay of plasmin in fibrinolytic agents are described which are based upon the determinations of AE/min during the linear portion of the casein-plasmin and fibrin-plasmin reaction curves respectively. A " caseinolytic-rate " unit and “fibrinolytic-rate " unit of ÄE/min × 103 during the linear portion ...
Mary Belle Frey, K. M Moser
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Pharmacology of fibrinolytic agents
Progress in Cardiovascular Diseases, 1979T HE appreciation of the high morbidity and mortality from thromboembolic occlusive vascular disease has given the impetus to a continuing search for drugs that might be of clinical value in its prevention and treatment. Anticoagulant therapy with heparin or the oral anticoagulants is primarily prophylactic, and while these drugs can prevent the ...
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Biochemistry, 1996
A conjugate of annexin V and the B-chain of urokinase was prepared and its fibrinolytic properties were studied. First, a mutant of annexin V was constructed with an N-terminal extension of six amino acids (Met-Ala-Cys-Asp-His-Ser) and with Cys316 ...
Kenji Tanaka +4 more
semanticscholar +1 more source
A conjugate of annexin V and the B-chain of urokinase was prepared and its fibrinolytic properties were studied. First, a mutant of annexin V was constructed with an N-terminal extension of six amino acids (Met-Ala-Cys-Asp-His-Ser) and with Cys316 ...
Kenji Tanaka +4 more
semanticscholar +1 more source
Acyl-Enzymes As Fibrinolytic Agents [PDF]
Thrombosis and Haemostasis, 1981 Plasminogen activators or plasmins specifically and reversibly acylated at the active centre have been used as delivery systems for fibrinolytic agents in vivo. Potential advantages of this approach, including enhanced efficacy, reduced toxicity and better control of lysis are discussed.
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Tenecteplase: A fibrinolytic agent
British Journal of Cardiac Nursing, 2006Thrombolysis is an established therapy for acute myocardial infarction in the UK. ST-elevation myocardial infarction almost always occurs owing to coronary atherosclerosis and coronary thrombosis which develops because of plaque disruption. Fibrinolytic agents act to dissolve the clot.
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ROLE OF FIBRINOLYTIC AGENTS IN THROMBOTIC DISEASES
Journal of the American Medical Association, 1960Critical analysis of existing data demonstrates that fibrinolysin in conjunction with anticoagulant therapy decreases the morbidity in patients with thrombophlebitis. This conclusion was the result of comparison of data from hospital charts of 20 patients in a fibrinolysin-treated series and a control group of 22 patients. The comparison was made after
R. V. Chapple, H. O. Singher
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Fibrinolytic Agents: Mechanisms of Activity and Pharmacology
Thrombosis and Haemostasis, 1995Fibrinolytic (thrombolytic) agents activate the fibrinolytic system by conversion of the inactive proenzyme, plasminogen into the active enzyme plasmin, that degrades fibrin. Agents available for clinical use are: the physiologic tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA)--either in a single chain (scu-PA ...
D. Collen, H.R. Lijnen
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Monitoring activity of fibrinolytic agents
The American Journal of Medicine, 1984The recognition that thrombolytic therapy may be beneficial for coronary thrombolysis has led to an increased use of plasminogen activators in critically ill patients, sometimes with inadequate monitoring. This review delineates the components of the fibrinolytic system, describes mechanisms of fibrinolysis, and presents practical guidelines for ...
Kenneth E. Shafer +3 more
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Local Release of Fibrinolytic Agents for Adhesion Prevention
Journal of Surgical Research, 1995Tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and streptokinase were evaluated for their ability to reduce postsurgical adhesion formation in a rat uterine horn devascularization and serosal injury model in a blinded, randomized study.
Hill-West, J. L. +2 more
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Fibrinolytic agents in the treatment of intraventricular hemorrhage in adults [PDF]
Critical Reviews in Neurosurgery, 1998 This paper aims to review current literature on the treatment of acute intraventricular hemorrhage in adults with intraventricular infusion of fibrinolytic agents. A literature search on the topics of "intraventricular hemorrhage" or "intracerebral hemorrhage" with "thrombolytic therapy", "fibrinolytic therapy", "urokinase", "streptokinase", "tissue ...
Stephen J. Haines, Marc Lapointe
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