Results 221 to 230 of about 24,629 (256)
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Pharmacology of fibrinolytic agents
Progress in Cardiovascular Diseases, 1979T HE appreciation of the high morbidity and mortality from thromboembolic occlusive vascular disease has given the impetus to a continuing search for drugs that might be of clinical value in its prevention and treatment. Anticoagulant therapy with heparin or the oral anticoagulants is primarily prophylactic, and while these drugs can prevent the ...
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Acyl-Enzymes As Fibrinolytic Agents [PDF]
Thrombosis and Haemostasis, 1981 Plasminogen activators or plasmins specifically and reversibly acylated at the active centre have been used as delivery systems for fibrinolytic agents in vivo. Potential advantages of this approach, including enhanced efficacy, reduced toxicity and better control of lysis are discussed.
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Tenecteplase: A promising new fibrinolytic agent
Dimensions of Critical Care Nursing, 2001Acute coronary syndrome can mean anything from unstable angina to acute myocardial infarction (MI) with ST-segment elevation. Tenecteplase, a new fibrinolytic agent used to treat ST-segment elevation acute MI, has some advantages over other fibrinolytic agents. This article describes tenecteplase's actions, indications, contraindications, and use.
Sabadie-Garretson W, De Jong Mj
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Antibody-Directed Urokinase: A Specific Fibrinolytic Agent [PDF]
Science, 1985 A specific fibrinolytic agent was synthesized by covalently coupling urokinase to a monoclonal antibody that was fibrin-specific and did not cross-react with fibrinogen. The antibody was raised against a synthetic peptide representing the seven amino-terminal residues of the beta chain of human fibrin.
Kwan Y. Hui +3 more
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Tenecteplase: A fibrinolytic agent
British Journal of Cardiac Nursing, 2006Thrombolysis is an established therapy for acute myocardial infarction in the UK. ST-elevation myocardial infarction almost always occurs owing to coronary atherosclerosis and coronary thrombosis which develops because of plaque disruption. Fibrinolytic agents act to dissolve the clot.
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ROLE OF FIBRINOLYTIC AGENTS IN THROMBOTIC DISEASES
Journal of the American Medical Association, 1960Critical analysis of existing data demonstrates that fibrinolysin in conjunction with anticoagulant therapy decreases the morbidity in patients with thrombophlebitis. This conclusion was the result of comparison of data from hospital charts of 20 patients in a fibrinolysin-treated series and a control group of 22 patients. The comparison was made after
R. V. Chapple, H. O. Singher
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Fibrinolytic Agents: Mechanisms of Activity and Pharmacology
Thrombosis and Haemostasis, 1995Fibrinolytic (thrombolytic) agents activate the fibrinolytic system by conversion of the inactive proenzyme, plasminogen into the active enzyme plasmin, that degrades fibrin. Agents available for clinical use are: the physiologic tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA)--either in a single chain (scu-PA ...
D. Collen, H.R. Lijnen
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Monitoring activity of fibrinolytic agents
The American Journal of Medicine, 1984The recognition that thrombolytic therapy may be beneficial for coronary thrombolysis has led to an increased use of plasminogen activators in critically ill patients, sometimes with inadequate monitoring. This review delineates the components of the fibrinolytic system, describes mechanisms of fibrinolysis, and presents practical guidelines for ...
Kenneth E. Shafer +3 more
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Fibrinolytic agents in the treatment of intraventricular hemorrhage in adults [PDF]
Critical Reviews in Neurosurgery, 1998 This paper aims to review current literature on the treatment of acute intraventricular hemorrhage in adults with intraventricular infusion of fibrinolytic agents. A literature search on the topics of "intraventricular hemorrhage" or "intracerebral hemorrhage" with "thrombolytic therapy", "fibrinolytic therapy", "urokinase", "streptokinase", "tissue ...
Stephen J. Haines, Marc Lapointe
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Local Release of Fibrinolytic Agents for Adhesion Prevention
Journal of Surgical Research, 1995Tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and streptokinase were evaluated for their ability to reduce postsurgical adhesion formation in a rat uterine horn devascularization and serosal injury model in a blinded, randomized study.
Randall C. Dunn +2 more
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