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Pharmacokinetics and Pharmacodynamics of Fibrinolytic Agents
2015In this chapter, the historical development, as well as, pharmacokinetics and pharmacological properties of the more frequently used fibrinolytic agents in pulmonary embolism patients, namely streptokinase, alteplase, and tenecteplase are analyzed. The historical development of the first-, second-, and third-generation fibrinolytics has been reviewed ...
H. David Rodriguez +1 more
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1978
The prophylaxis and treatment of thromboembolic disorders have long involved the use of anticoagulants administered either parenterally or via the oral route. However, at the present time, there is no longer unanimity regarding the effectiveness of this medication, due to the difficulties of objective assessment of all of the parameters of ...
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The prophylaxis and treatment of thromboembolic disorders have long involved the use of anticoagulants administered either parenterally or via the oral route. However, at the present time, there is no longer unanimity regarding the effectiveness of this medication, due to the difficulties of objective assessment of all of the parameters of ...
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Quantitation of fibrinolytic agents released in tissue culture
Experientia, 1971Es wird eine neue Methode zur Bestimmung der freigesetzten Menge fibrinolytisch wirksamer Stoffe in Gewebekulturen beschrieben. Das Gewebe wird in Leightonrohrchen mit einem standardisierten Fibringerinnsel gezuchtet. Die abgebaute Fibrinmenge — als Mass der fibrinolytischen Aktivitat — wird durch immunologische Bestimmung der Spaltprodukte gemessen.
Inga Marie Nilsson +2 more
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The treatment of cerebrovascular thromboses and embolism with fibrinolytic agents
The American Journal of Cardiology, 1960H UMAN fibrinolysin and streptokinaset have been shown to dissolve fresh intravascular thrombi in several pathologic situations.1-3 These agents have been administered to extremely ill patients without serious side effects. Our results and those of others in treatment of patients with peripheral thrombophlebitis, peripheral arterial thrombosis and ...
Robert L. Clarke, Eugene E. Cliffton
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The use of fibrinolytic agents in the treatment of arterial occlusion
The American Journal of Surgery, 1962Abstract The experience gained in the treatment of forty-three patients with acute arterial occlusions is reported. It is believed that on the basis of this experience that prompt local instillation of large amounts of fibrinolytic agents, plus embolectomy or endarterectomy when indicated, will lead to rapid resolution of the acute arterial ...
Eugene E. Cliffton, Robert L. Clarke
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Greater use of fibrinolytic agents urged
JAMA: The Journal of the American Medical Association, 1980The thrombolytic agents urokinase and streptokinase are safe and more effective than traditional anticoagulants in treating deep-vein thrombosis and pulmonary embolism in carefully selected patients, a panel of experts convened by the National Institutes of Health (NIH) has concluded.
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Synthetic Fibrinolytic Agents Induction of Fibrinolytic Activity In Vitro
1978Various asymmetric organic anions have been shown to possess the important capacity to enhance the endogenous fibrinolytic activity in human plasma in vitro. Their further development may well permit induction with them of the thrombolytic activity in human blood in vivo resulting in intravascular clot (thrombi, emboli) dissolution (thrombolysis) by ...
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Treatment of thrombophlebitis with a fibrinolytic agent
The American Journal of Cardiology, 1960Abstract 1. 1. Fibrinolysin was administered to seventy-one patients in 218 separate intravenous infusions. Each infusion contained 50,000 to 100,000 Merck units dissolved in 100 to 250 ml. of 5 per cent glucose in water and was given over a half- to two-hour period. Side effects were limited to hyperpyrexia of 2 °F.
Nancy D. Davis +2 more
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Treatment of Experimental Total Hyphemas With Intraocular Fibrinolytic Agents
Archives of Ophthalmology, 1962Traumatic hyphema is always potentially dangerous. Total hyphema ("eight-ball hemorrhage") has an especially poor prognosis because it often results in glaucoma, iris atrophy, and hematogenous pigmentation of the cornea. The types of treatment advocated for traumatic hyphema include bed rest, sedatives, miotics, mydriatics, carbonic anhydrase ...
Abraham Pollen +2 more
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Fibrinolytic agents: pharmacology, indications and prescribing
Nurse Prescribing, 2011Fibrinolytic (thrombolytic) agents are used thrombolysis (clot breakdown) in several indications, including acute ST-elevation myocardial infarction, acute pulmonary embolism and acute ischaemic stroke. The pathophysiology of each condition is discussed, as well as indications for the use of fibrinolytic agents.
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