Results 31 to 40 of about 24,815 (217)

Tissue plasminogen activator-based clot busting: Controlled delivery approaches. [PDF]

, 2014
Cardiovascular diseases are the leading cause of death worldwide. Thrombosis, the formation of blood clot (thrombus) in the circulatory system obstructing the blood flow, is one of the main causes behind various ischemic arterial syndromes such as ...
El-Sherbiny, IM, Elkholi, IE, Yacoub, MH
core   +1 more source

The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. [PDF]

PLoS Pathogens, 2009
The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated.
Joppe W R Hovius, Maarten F Bijlsma, Gerritje J W van der Windt, W Joost Wiersinga, Bastiaan J D Boukens, Jeroen Coumou, Anneke Oei, Regina de Beer, Alex F de Vos, Cornelis van 't Veer, Alje P van Dam, Penghua Wang, Erol Fikrig, Marcel M Levi, Joris J T H Roelofs, Tom van der Poll   +15 more
doaj   +1 more source

ST-Elevation myocardial infarction network: systematization in 205 cases reduced clinical events in the public health care system [PDF]

, 2012
BACKGROUND: The major cause of death in the city of São Paulo (SP) is cardiac events. At its periphery, in-hospital mortality in acute myocardial infarction is estimated to range between 15% and 20% due to difficulties inherent in large metropoles ...
Alves, Claudia Maria Rodrigues, Barbosa, Adriano H., Caluza, Ana Christina Vellozo, Carvalho, Antonio Carlos, Gonçalves, Iran, Matos, Lívia Nascimento de, Moreno, Antonio Célio C., Oliveira, Carlos Alexandre L. de, Tarkieltaub, Elcio, Zeefried, Claus   +9 more
core   +3 more sources

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk [PDF]

, 2017
An enhanced thrombotic environment and premature atherosclerosis are key factors for the increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed secondary to interactions between platelets and coagulation proteins, is composed ...
A Agren, A Ceriello, A Hamsten, A Hamsten, A Lados-Krupa, A Liang, A Lutjens, A Rouch, A Rupin, A Sahebkar, A Tripodi, A Undas, A Undas, A Undas, AH Guimaraes, AH Henschen-Edman, AH Straten van, AS Wolberg, AS Wolberg, B Blomback, B Craen Van De, B Lipinski, B Rocca, B Wiman, B Zinman, BH Shieh, C Longstaff, CH Lundgren, CH Nair, CL Nikolajsen, CS Fox, D Capodanno, D Hill, D Leenaerts, D Ricklin, DA Gabriel, DA Lawrence, DA Lawrence, Darren Tomlinson, DJ Schneider, DL Crandall, DV Sakharov, E Angelantonio Di, E Chow, E Ernst, E Pretorius, E Pretorius, E Shacter, E Vercauteren, EG Levin, EJ Dunn, EJ Dunn, EL Hethershaw, EM Sherif, F Denorme, F Rollini, G Boden, G Gajos, G Jorneskog, GJ Brouwers, GK Hansson, GL Booth, GL Reed 3rd, GL Reed 3rd, H Elokdah, H Ritchie, HC Gerstein, HH Versteeg, HJ Beijers, HK Kim, I Juhan-Vague, I Shimomura, J Bester, J Danesh, J Montaner, J Svensson, J Weisel, JA Dormandy, JC Chapin, JD Mills, JG Dillinger, JH Foley, JL Ferreiro, JL Mega, JM Howes, JP Collet, JP Collet, JW Weisel, K Bangert, K Buelens, K Distelmaier, K Fatah, K Hess, K Hess, K Hess, K Leander, K Leander, Katherine Kearney, KE Brummel, Kerrie Smith, KN Lee, KN Lee, KN Lee, KN Lee, KN Lee, KR Machlus, L Badimon, L Ryden, L Wallentin, LM Belalcazar, M Konieczynska, M Pieters, M Pieters, M Pieters, M Rigla, M Udvardy, MA Bailey, MB Kahn, MC Alessi, ME Carr Jr, ME Meltzer, ME Meltzer, ME Meltzer, ME Stegenga, MG Marini, MR Hammer, MS Ardawi, N Gogitidze Joy, N Zheng, NH Tilburg van, NV Gorlatova, O Sigurdardottir, OJ Phung, P Chudy, P Clemmensen, P Katz, P Kohli, P Soma, P Soma, R Ajjan, R Favier, R King, RA Ajjan, RA Ajjan, RA Al-Horani, Ramzi Ajjan, RM Cubbon, RM Missov, RP Rother, RR Holman, S James, S Kimura, S Kimura, S Neergaard-Petersen, S Schulman, S Tehrani, S Tehrani, S Yener, SD Wiviott, SD Wiviott, SH Alzahrani, SH Alzahrani, SJ Cleland, SK Kunutsor, SL Carpenter, SP Marso, SR Fraser, ST Lord, T Koyama, T Kumada, T Lisman, T Plug, T Sasaki, T Tamaki, T Wyseure, T Wyseure, TC Holten van, TW Meade, U Amara, V Baeriswyl, VR Richardson, WB Kannel, X Zhou, X Zhou, Y Hori, Y Sakata, Y Sakata, Y Sakata, Y Sumi, Y Yano, YM Fortenberry, Z Valnickova   +191 more
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Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. [PDF]

, 2009
PurposeDeposition of fibrin in the alveolar space is a hallmark of acute lung injury (ALI). Plasminogen activator inhibitor-1 (PAI-1) is an antifibrinolytic agent that is activated during inflammation. Increased plasma and pulmonary edema fluid levels of
Brady, Sandra, Curley, Martha AQ, Flori, Heidi, Matthay, Michael A, Sapru, Anil   +4 more
core   +2 more sources

Comparison of the methods of fibrinolysis by tube thoracostomy and thoracoscopic decortication in children with stage II and III empyema: a prospective randomized study

Pediatric Reports, 2011
Today, in spite of the developments in imaging methods and antibiotherapy, childhood pleural empyema is a prominent cause of morbidity and mortality. In recent years, it has been shown that there has been an increase in the frequency of pleural empyema ...
Ufuk Cobanoglu, Fuat Sayir, Salim Bilici, Mehmet Melek   +3 more
doaj   +1 more source

Cessation of dual antiplatelet therapy and cardiovascular events following acute coronary syndrome [PDF]

, 2019
Objective: To assess whether cardiovascular events are increased after cessation of dual antiplatelet therapy (DAPT) following acute coronary syndrome (ACS) and to explore predictors for recurrent events after DAPT cessation during long-term follow-up.
Berry, Colin, Dawson, Jesse, Mazlan-Kepli, Wardati, Walters, Matthew   +3 more
core   +1 more source

Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha

BMC Biotechnology, 2012
Background Currently, the two most commonly used fibrinolytic agents in thrombolytic therapy are recombinant tissue plasminogen activator (rt-PA) and streptokinase (SK).
Moussa Manal, Ibrahim Mahmoud, El Ghazaly Maria, Rohde Jan, Gnoth Stefan, Anton Andreas, Kensy Frank, Mueller Frank   +7 more
doaj   +1 more source

Effect of the administration of recombinant hirudin and/or tissue-plasminogen activator (t-PA) on endotoxin-induced disseminated intravascular coagulation model in rabbits [PDF]

, 1999
We evaluated the effect of r-hirudin and/or tissue-plasminogen activator (t-PA) in a model of DIC in rabbits induced by i.v. infusion of 100 micrograms/kg/h/6 h endotoxin. Rabbits were treated with saline (endotoxin control group), r-hirudin at 0.3 mg/kg/
Hermida, J. (José), Montes, R. (Ramón), Muñoz, M.C. (María Carmen), Orbe, J. (Josune), Paramo, J.A. (José Antonio), Rocha, E. (Eduardo)   +5 more
core   +1 more source

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source