Results 61 to 70 of about 3,180,492 (237)

Research progress of antibody coupling technique in targeted drug delivery

Interdisciplinary Medicine, EarlyView.
Abstract Antibody‐drug conjugates are a cutting‐edge biotechnology recently attracting wide attention in the medical field. Binding antibodies to drug molecules could deliver drugs precisely to the site of the lesion, which shows great potential in the treatment of tumors and immune diseases.
Meng Li, Tiantian Wang, Dan Tan, Mengqi Wang, Changhai Lei, Yuqing Wang, Shi Hu   +6 more
wiley   +1 more source

Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha

BMC Biotechnology, 2012
Background Currently, the two most commonly used fibrinolytic agents in thrombolytic therapy are recombinant tissue plasminogen activator (rt-PA) and streptokinase (SK).
Moussa Manal, Ibrahim Mahmoud, El Ghazaly Maria, Rohde Jan, Gnoth Stefan, Anton Andreas, Kensy Frank, Mueller Frank   +7 more
doaj   +1 more source

Role of intrapleural instillation of MESNA in the management of pleural adhesions

Egyptian Journal of Chest Disease and Tuberculosis, 2022
Context Intrapleural adhesions and pleural fluid loculation is a common clinical problem. Several options are available to manage the intrapleural adhesions. MESNA has recently been used as a fibrinolytic agent and due to its efficacy and safety it is an
Amany Omar, Abd-Elazim Abo Elfadl, Yousef Ahmed, Hussein Elkhayat, Montaser Gamal   +4 more
doaj   +1 more source

Recent advances in cardiovascular medicines : thrombolytics [PDF]

, 1990
Thrombolytic therapy represents a major advance in reducing mortality following myocardial infarction. Pharmacists must be aware of the principles and problems of thrombolysis and the extant large studies conducted in hospitals and in the community. This
Felice, Herbert, Gatt, Marise, Harron, Dean   +2 more
core  

Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism [PDF]

, 2011
BACKGROUND: The fibrinolytic and matrix metalloproteinase (MMP) systems cooperate in thrombus dissolution and extracellular matrix proteolysis. The plasminogen/plasmin system activates MMPs, and some MMPs have been involved in the dissolution of fibrin ...
Angles-Cano, E. (Eduardo), Barrenetxe, J. (Jaione), Birkland, T.P. (T.P.), Martinez-de-Lizarrondo, S. (Sara), Orbe, J. (Josune), Orset, C. (C.), Paramo, J.A. (José Antonio), Parks, W.C. (W.C.), Purroy, A. (A.), Rodriguez, J.A. (José Antonio), Serrano, R. (Rosario), Vivien, D. (D.)   +11 more
core   +1 more source

Angioedema following venipuncture in a patient on angiotensin‐converting enzyme inhibitor and dipeptidyl peptidase‐IV inhibitor therapy: A case report

JEADV Clinical Practice, EarlyView.
Abstract Acquired angioedema (AAE) is a rare, potentially life‐threatening condition, primarily induced by medications, with attacks typically triggered by major trauma. We report a rare case of AAE triggered locally by minor trauma—a forearm venipuncture—in a 77‐year‐old male taking ramipril and sitagliptin.
Adrien Bénic, Adrien Boyard, Alexan Pogossian, Laurent Misery, Anne‐Marie Roguedas‐Contios   +4 more
wiley   +1 more source

Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At‐Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers

Molecular Nutrition &Food Research, EarlyView.
Yerba mate intake shows cardiometabolic beneficial effects decreasing blood pressure, blood lipids, inflammatory biomarkers and body fat in healthy and hypercholesterolemic non‐habitual consumers. ABSTRACT Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties.
Laura Bravo, Sara Martínez‐López, Jose Luis Sierra‐Cinos, Raquel Mateos, Beatriz Sarriá   +4 more
wiley   +1 more source

Cow Dung Is a Novel Feedstock for Fibrinolytic Enzyme Production from Newly Isolated Bacillus sp. IND7 and Its Application in In Vitro Clot Lysis [PDF]

, 2016
Bacterial fibrinolytic enzymes find great applications to treat and prevent cardiovascular diseases. The novel fibrinolytic enzymes from food grade organisms are useful for thrombolytic therapy.
Arumugaperumal Arun, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Ponnuswamy Vijayaraghavan, Samuel Gnana Prakash Vincent   +4 more
core   +2 more sources

Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation.

New England Journal of Medicine, 2005
BACKGROUND A substantial proportion of patients receiving fibrinolytic therapy for myocardial infarction with ST-segment elevation have inadequate reperfusion or reocclusion of the infarct-related artery, leading to an increased risk of complications and
M. Sabatine, C. Cannon, C. Gibson, J. López-Sendón, G. Montalescot, P. Théroux, M. Claeys, F. Cools, K. A. Hill, A. Skene, C. Mccabe, E. Braunwald   +11 more
semanticscholar   +1 more source

Uptake of orally administered tranexamic acid in women during active labor: A pilot intervention study on prophylactic treatment of postpartum hemorrhage

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Women in active labor given oral tranexamic acid do reach therapeutic plasma concentrations. Time to therapeutic concentration is longer compared with intravenous administration, but duration in the therapeutic interval is significantly longer. Abstract Introduction Postpartum hemorrhage is the leading cause of maternal mortality worldwide.
Gita Strindfors, Pelle G. Lindqvist, Margit Endler   +2 more
wiley   +1 more source