Screening, production and biochemical characterization of a new fibrinolytic enzyme produced by Streptomyces sp. (Streptomycetaceae) isolated from Amazonian lichens [PDF]
Thrombosis is a pathophysiological disorder caused by accumulation of fibrin in the blood. Fibrinolytic proteases with potent thrombolytic activity have been produced by diverse microbial sources.
Afifah D.N.+40 more
core +2 more sources
Coagulopathy as a Complication of Cardiopulmonary Arrest Following Balloon Valvuloplasty in a Dog
An 8‐month‐old dog developed a consumptive coagulopathy and presumptive DIC following cardiac arrest during a balloon valvuloplasty procedure. Successful management required massive transfusion therapy and critical care. ABSTRACT Objective To describe successful management of a coagulopathy secondary to cardiopulmonary arrest (CPA) associated with ...
Marissa A. Turner, Theresa C. Hallowell
wiley +1 more source
Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk [PDF]
An enhanced thrombotic environment and premature atherosclerosis are key factors for the increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed secondary to interactions between platelets and coagulation proteins, is composed ...
A Agren+191 more
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In a rat model of intra‐abdominal adhesions, Vitamin E (vit E) and Nigella sativa (NS) oil were compared for their therapeutic effects. While both reduced inflammation and fibrosis, vit E demonstrated superior efficacy, significantly lowering TNF‐α levels, reducing fibrosis, and enhancing collagen maturation.
Musa Ozekinci+3 more
wiley +1 more source
Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions
Postsurgical adhesions are a common complication of surgical procedures that can lead to postoperative pain, bowel obstruction, infertility, as well as complications with future procedures. Several agents have been developed to prevent adhesion formation,
Jiahui Chen+7 more
doaj +1 more source
Recent advances in cardiovascular medicines : thrombolytics [PDF]
Thrombolytic therapy represents a major advance in reducing mortality following myocardial infarction. Pharmacists must be aware of the principles and problems of thrombolysis and the extant large studies conducted in hospitals and in the community. This
Felice, Herbert+2 more
core
Production and characterization of new fibrinolytic protease from Mucor subtillissimus UCP 1262 in solid-state fermentation [PDF]
Fibrinolytic enzymes have received attention regarding their medicinal potential for thrombolytic diseases, a leading cause of morbidity and mortality worldwide.
Brandão, Romero Marcos Pedrosa+7 more
core +1 more source
Women in active labor given oral tranexamic acid do reach therapeutic plasma concentrations. Time to therapeutic concentration is longer compared with intravenous administration, but duration in the therapeutic interval is significantly longer. Abstract Introduction Postpartum hemorrhage is the leading cause of maternal mortality worldwide.
Gita Strindfors+2 more
wiley +1 more source
Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). [PDF]
OBJECTIVE: To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumatic brain injury.
CRASH-2 Collaborators, Intracranial Bleeding Study
core +1 more source
Clot formation and resolution properties of platelets during cold storage for 21 days
Abstract Background Cold storage (2–6°C) preserves the aggregatory and clot formation properties of platelets beyond the standard 7‐day shelf life. Comparatively little is known about the effect of cold storage on clot resolution functions, which are necessary to ensure normal hemostatic balance is maintained.
Janhavi Mahajan+3 more
wiley +1 more source