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Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast-myocyte coupling [PDF]
, 2016 Fibroblast-myocyte coupling can modulate electrical-wave dynamics in cardiac tissue. In diseased hearts, the distribution of fibroblasts is heterogeneous, so there can be gradients in the fibroblast density (henceforth we call this GFD) especially from highly injured regions, like infarcted or ischemic zones, to less-wounded regions of the tissue ...
Pandit, Rahul, Zimik, Soling
arxiv +3 more sources
Nature Communications, 2021 Fibrotic skin disease represents a major global healthcare burden, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix.
Cheng-cheng Deng, Yongfei Hu, Bin Yang
exaly +2 more sources
Distinct fibroblast subsets drive inflammation and damage in arthritis
Nature, 2019 The identification of lymphocyte subsets with non-overlapping effector functions has been pivotal to the development of targeted therapies in immune-mediated inflammatory diseases (IMIDs)1,2. However, it remains unclear whether fibroblast subclasses with
Adam P Croft +2 more
exaly +2 more sources
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
Nature Communications, 2018 Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic inflammation which leads to joint destruction.
Fumitaka Mizoguchi +2 more
exaly +2 more sources
Cross-tissue organization of the fibroblast lineage
Nature, 2021 Akshay T Krishnamurty +2 more
exaly +2 more sources
A transcriptional switch governs fibroblast activation in heart disease
Nature, 2021 Pawel F Przytycki +2 more
exaly +2 more sources
Resveratrol Prevents High Fluence Red Light-Emitting Diode Reactive Oxygen Species-Mediated Photoinhibition of Human Skin Fibroblast Migration. [PDF]
, 2015 BackgroundSkin fibrosis is a significant medical problem that leads to a functional, aesthetic, and psychosocial impact on quality-of-life. Light-emitting diode-generated 633-nm red light (LED-RL) is part of the visible light spectrum that is not known ...
Isseroff, R Rivkah +4 more
core +13 more sources
Fibroblast Activation Protein Specific Optical Imaging in Non-Small Cell Lung Cancer
Frontiers in Oncology, 2022 Fibroblast activation protein (FAP) is a cell surface propyl-specific serine protease involved in the regulation of extracellular matrix. Whilst expressed at low levels in healthy tissue, upregulation of FAP on fibroblasts can be found in several solid ...
Layla Mathieson +12 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Pulmonary fibrosis is a group of life-threatening diseases with limited therapeutic options. The involvement of cannabinoid type 1 receptors (CB1R) has been indicated in fibrotic diseases, but whether or not the activation of CB1R can be a benefit for ...
Dongxin Chen +6 more
doaj +1 more source
Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease
Frontiers in Cellular Neuroscience, 2021 The meninges are the fibrous covering of the central nervous system (CNS) which contain vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia).
Julia Derk +8 more
doaj +1 more source