Results 21 to 30 of about 443,746 (265)

KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes’ phenotypes

Frontiers in Immunology
BackgroundHuntingtin-interacting protein-1 (HIP1) is a new arthritis severity gene implicated in the regulation of the invasive properties of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS).
Teresina Laragione, Carolyn Harris, Percio S. Gulko   +2 more
doaj   +1 more source

Effects of Different Titanium Anodized Surfaces on Peri-Implant Soft Tissue Healing Around Dental Abutments: In Vitro and Proteomic Study

Applied Sciences
Objectives: This study aimed to evaluate the effects of different titanium (Ti) anodized surfaces on soft tissue healing around dental implant abutments.
Francisco Romero-Gavilán, Andreia Cerqueira, Carlos Arias-Mainer, David Peñarrocha-Oltra, Claudia Salavert-Martínez, Juan Carlos Bernabeu-Mira, Iñaki García-Arnáez, Félix Elortza, Mariló Gurruchaga, Isabel Goñi, Julio Suay   +10 more
doaj   +1 more source

Direct Conversion of Human Fibroblasts into Adipocytes Using a Novel Small Molecular Compound: Implications for Regenerative Therapy for Adipose Tissue Defects

Cells, 2021
There is a need in plastic surgery to prepare autologous adipocytes that can be transplanted in patients to reconstruct soft tissue defects caused by tumor resection, including breast cancer, and by trauma and other diseases. Direct conversion of somatic
Yoshihiro Sowa, Tsunao Kishida, Fiona Louis, Seiji Sawai, Makoto Seki, Toshiaki Numajiri, Kenji Takahashi, Osam Mazda   +7 more
doaj   +1 more source

Small Molecule Cocktails Promote Fibroblast-to-Leydig-like Cell Conversion for Hypogonadism Therapy

Pharmaceutics, 2023
Male hypogonadism arises from the inadequate production of testosterone (T) by the testes, primarily due to Leydig cell (LC) dysfunction. Small molecules possess several advantages, including high cell permeability, ease of synthesis, standardization ...
Fei Yuan, Kaiping Bai, Yanping Hou, Xiangyu Zou, Jie Sun   +4 more
doaj   +1 more source

Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway

eLife
The fibroblast (FB), cardiomyocyte (CM), and vascular endothelial cell (Vas_EC) are the three major cell types in the heart, yet their relationships during development are largely unexplored. To address this gap, we employed RNA staining of the FB marker
Yiting Deng, Yuanhang He, Juan Xu, Haoting He, Manling Zhang, Guang Li   +5 more
doaj   +1 more source

A clinical study on relationship between visualization of cardiac fibroblast activation protein activity by Al18F-NOTA-FAPI-04 positron emission tomography and cardiovascular disease

Frontiers in Cardiovascular Medicine, 2022
ObjectiveFAP plays a vital role in myocardial injury and fibrosis. Although initially used to study imaging of primary and metastatic tumors, the use of FAPI tracers has recently been studied in cardiac remodeling after myocardial infarction.
Zhehao Lyu, Wei Han, Hongyue Zhao, Yuying Jiao, Peng Xu, Yangyang Wang, Qiuyi Shen, Shuai Yang, Changjiu Zhao, Lin Tian, Peng Fu   +10 more
doaj   +1 more source

Pro-Inflammatory Properties of Salivary Gland-Derived Fibroblasts—Implications in Sjögren’s Disease

Cells
Salivary gland dysfunction is a hallmark of Sjögren’s disease (SjD). Here, we investigated the pro-inflammatory properties of salivary gland-derived fibroblasts (SGF) that were cultured from minor salivary gland (MSG) tissues of patients with SjD and ...
Matthias Brunner, Daniel Guggisberg, Marco Sprecher, Ondrej Pastva, Kristina Bürki, Miranda Houtman, Marco Kreuzer, Sara Andrea Krättli, Laura Jahnke, Mila Roceri, Rémy Bruggmann, Muriel Elhai, Britta Maurer, Thomas M. Marti, Caroline Ospelt, Kerstin Klein   +15 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

IL-17A drives a fibroblast-neutrophil-NET axis to exacerbate immunopathology in the lung with diffuse alveolar damage

Frontiers in Immunology
Diffuse alveolar damage (DAD), a lethal manifestation of acute lung injury, remains a critical public health concern due to the absence of targeted therapies.
Duo Su, Duo Su, Lu Li, Hao Xie, Lingli Ai, Yuqing Wang, Bo Yang, Dongsheng Zhou, Lingfei Hu, Huiying Yang   +9 more
doaj   +1 more source

Fibroblast Activation Protein Specific Optical Imaging in Non-Small Cell Lung Cancer

Frontiers in Oncology, 2022
Fibroblast activation protein (FAP) is a cell surface propyl-specific serine protease involved in the regulation of extracellular matrix. Whilst expressed at low levels in healthy tissue, upregulation of FAP on fibroblasts can be found in several solid ...
Layla Mathieson, Layla Mathieson, Richard A. O’Connor, Richard A. O’Connor, Hazel Stewart, Paige Shaw, Kevin Dhaliwal, Kevin Dhaliwal, Gareth O. S. Williams, Alicia Megia-Fernandez, Ahsan R. Akram, Ahsan R. Akram, Ahsan R. Akram   +12 more
doaj   +1 more source