Results 31 to 40 of about 746,101 (309)

Generation and characterisation of Friedreich ataxia YG8R mouse fibroblast and neural stem cell models [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Background: Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by GAA repeat expansion in the first intron of the FXN gene, which encodes
A Durr, A Filla, A Halabi, A Hick, A Rotig, A Wong, AH Koeppen, AL Bulteau, AM Khalil, Annalisa Pastore, BL Sopher, C Gellera, C Sandi, CH Zuhlke, Chiranjeevi Sandi, D Marmolino, D Marmolino, D Waldvogel, DH Cho, DW Chung, E Greene, F Foury, G Coppola, G Tan, GS Chandok, H Holemon, H Puccio, H Puccio, H Van Remmen, Harvinder Jassal, I Castaldo, I De Biase, I De Biase, J Du, J Liu, J St-Pierre, JB Schulz, JH Willis, JL Bradley, JL García-Giménez, JP Sarsero, L Grant, L Montermini, L Pianese, L Schols, M Anheim, M Cossee, M Pandolfo, M Perdomini, MA Pook, Madhavi Sandi, Mark A. Pook, ML Moseley, MM Heidari, MM Lufino, MV Evans-Galea, MV Evans-Galea, N Calmels, N Sakamoto, PD Ladd, R Sharma, RA Vaubel, RL Bourn, RM Clark, S Al-Mahdawi, S Al-Mahdawi, S Al-Mahdawi, S Al-Mahdawi, S Ku, Sahar Al-Mahdawi, Sara Anjomani-Virmouni, SW Levison, T Geng, V Campuzano, V Campuzano, V Ezzatizadeh, Vahid Ezzatizadeh, Y Shan   +77 more
core   +2 more sources

Effects of Different Titanium Anodized Surfaces on Peri-Implant Soft Tissue Healing Around Dental Abutments: In Vitro and Proteomic Study

Applied Sciences
Objectives: This study aimed to evaluate the effects of different titanium (Ti) anodized surfaces on soft tissue healing around dental implant abutments.
Francisco Romero-Gavilán, Andreia Cerqueira, Carlos Arias-Mainer, David Peñarrocha-Oltra, Claudia Salavert-Martínez, Juan Carlos Bernabeu-Mira, Iñaki García-Arnáez, Félix Elortza, Mariló Gurruchaga, Isabel Goñi, Julio Suay   +10 more
doaj   +1 more source

Direct Conversion of Human Fibroblasts into Adipocytes Using a Novel Small Molecular Compound: Implications for Regenerative Therapy for Adipose Tissue Defects

Cells, 2021
There is a need in plastic surgery to prepare autologous adipocytes that can be transplanted in patients to reconstruct soft tissue defects caused by tumor resection, including breast cancer, and by trauma and other diseases. Direct conversion of somatic
Yoshihiro Sowa, Tsunao Kishida, Fiona Louis, Seiji Sawai, Makoto Seki, Toshiaki Numajiri, Kenji Takahashi, Osam Mazda   +7 more
doaj   +1 more source

Role of Fibroblast Growth Factor Receptor 2 in Pancreatic Cancer: Potential Target for New Therapeutic Approach? [PDF]

, 2015
Fibroblast growth factors and their receptors play a key role in cell proliferation, migration and differentiation. Fibroblast growth factor receptor 2 (FGFR2) is involved in carcinogenesis and its altered expression has been shown in several tumors ...
Angeloni, Antonio, Ceccarelli, Simona, Vescarelli, Enrica   +2 more
core   +1 more source

Small Molecule Cocktails Promote Fibroblast-to-Leydig-like Cell Conversion for Hypogonadism Therapy

Pharmaceutics, 2023
Male hypogonadism arises from the inadequate production of testosterone (T) by the testes, primarily due to Leydig cell (LC) dysfunction. Small molecules possess several advantages, including high cell permeability, ease of synthesis, standardization ...
Fei Yuan, Kaiping Bai, Yanping Hou, Xiangyu Zou, Jie Sun   +4 more
doaj   +1 more source

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]

, 2015
The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P., Gronau, Julian H., King, Helen, Rodriguez-Teja, Mercedes, Shah, Neel, Sturge, Justin, Wang, Kai, Waxman, Jonathan   +7 more
core   +2 more sources

Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway

eLife
The fibroblast (FB), cardiomyocyte (CM), and vascular endothelial cell (Vas_EC) are the three major cell types in the heart, yet their relationships during development are largely unexplored. To address this gap, we employed RNA staining of the FB marker
Yiting Deng, Yuanhang He, Juan Xu, Haoting He, Manling Zhang, Guang Li   +5 more
doaj   +1 more source

A clinical study on relationship between visualization of cardiac fibroblast activation protein activity by Al18F-NOTA-FAPI-04 positron emission tomography and cardiovascular disease

Frontiers in Cardiovascular Medicine, 2022
ObjectiveFAP plays a vital role in myocardial injury and fibrosis. Although initially used to study imaging of primary and metastatic tumors, the use of FAPI tracers has recently been studied in cardiac remodeling after myocardial infarction.
Zhehao Lyu, Wei Han, Hongyue Zhao, Yuying Jiao, Peng Xu, Yangyang Wang, Qiuyi Shen, Shuai Yang, Changjiu Zhao, Lin Tian, Peng Fu   +10 more
doaj   +1 more source

Instability of spiral and scroll waves in the presence of a gradient in the fibroblast density: the effects of fibroblast-myocyte coupling

, 2016
Fibroblast-myocyte coupling can modulate electrical-wave dynamics in cardiac tissue. In diseased hearts, the distribution of fibroblasts is heterogeneous, so there can be gradients in the fibroblast density (henceforth we call this GFD) especially from ...
Pandit, Rahul, Zimik, Soling
core   +1 more source

Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. [PDF]

, 2018
Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains unknown.
Aguirre, Aitor, Chen, Haodong, Chour, Tony, Holmström, Alexandra, Itzhaki, Ilanit, Jain, Mohit, Kim, Youngkyun, Lehmann, Kim, Ndoye, Babacar C, Neofytou, Evgenios, Qin, Xulei, Shukla, Praveen, Wu, Joseph C, Xiao, Dan, Yang, Huaxiao, Zhang, Joe Z, Zhao, Mingtao, Zhao, Xin, Zhuge, Yan, Zimmermann, Wolfram-Hubertus   +19 more
core   +3 more sources