Results 131 to 140 of about 18,476 (229)

siRNA therapy in osteoarthritis: targeting cellular pathways for advanced treatment approaches

Frontiers in Immunology
Osteoarthritis (OA) is a common joint disorder characterized by the degeneration of cartilage and inflammation, affecting millions worldwide. The disease’s complex pathogenesis involves various cell types, such as chondrocytes, synovial cells ...
Yunshen Li, Yunshen Li, Yunshen Li, Jianan Zhao, Jianan Zhao, Jianan Zhao, Shicheng Guo, Dongyi He, Dongyi He, Dongyi He   +9 more
doaj   +1 more source

Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint

Journal of Translational Autoimmunity
Objective: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) alter their metabolism to support their activation. We aimed to analyse the full spectrum of metabolic alterations associated with RA by performing untargeted metabolomics in RA ...
Georgios K. Vasileiadis, Yuan Zhang, Marion Laudette, Tahzeeb Fatima, Anna-Karin Hultgård Ekwall, Reshmi Sureshkumar, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Gröndal, Kim Hørslev-Petersen, Kristina Lend, Merete L. Hetland, Michael Nurmohamed, Mikkel Østergaard, Till Uhlig, Tuulikki Sokka-Isler, Anna Rudin, Jan Borén, Monica Guma, Cristina Maglio   +22 more
doaj   +1 more source

ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis

Arthritis Research & Therapy
Objective Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) phenotype leads to an imbalance in the synovial inflammatory ...
Kai Chen, Huaqiang Tao, Pengfei Zhu, Miao Chu, Xueyan Li, Yi Shi, Liyuan Zhang, Yaozeng Xu, Shujun Lv, Lixin Huang, Wei Huang, Dechun Geng   +11 more
doaj   +1 more source

CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis

Journal of Orthopaedic Translation
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and bone destruction. Abnormal TNF/TNFR signaling leads to various dysregulations in Fibroblast-like synoviocytes (FLSs), including proliferation,
Xiaomeng Luo, Lingling Xu, Juan Cai, Siyang Ma, Haining Song, Pingting Yang, Chunshu Yang   +6 more
doaj   +1 more source

Andrographolide Ameliorates Inflammatory Changes Induced by D-Lactate in Bovine Fibroblast-like Synoviocytes

Animals
During acute ruminal acidosis, the manifestation of aseptic polysynovitis and lameness in cattle has been observed. Evidence suggests that joint inflammation can be attributed to the metabolic alterations induced by D-lactate in fibroblast-like ...
Stefanie Teuber, Carolina Manosalva, Pablo Alarcón, John Quiroga, Diana Pantoja, María Angélica Hidalgo, Gabriel Morán, Rafael Agustín Burgos   +7 more
doaj   +1 more source

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes [PDF]

, 2010
Isabel García-Arnandis, Maria Isabel Guillén, Francisco Gomar, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Maria José Alcaraz   +5 more
core   +1 more source

[Retracted] Quercetin promotes the apoptosis of fibroblast‑like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1. [PDF]

Int J Mol Med
Pan F, Zhu L, Lv H, Pei C.
europepmc   +1 more source

Effect of taurine chloramine on the production of matrix metalloproteinases (MMPs) in adiponectin- or IL-1β-stimulated fibroblast-like synoviocytes [PDF]

, 2010
Kyoung Kim, Hyun-Mi Choi, Da Oh, Chaekyun Kim, Jin Seok Jeong, Myung Yoo, Hyung-In Yang   +6 more
core   +1 more source

METTL3-mediated fibroblast-like synoviocytes senescence promotes temporomandibular joint osteoarthritis progression. [PDF]

Commun Biol
Tian K, Du Q, Guo J, Liao W, Yang X, Lai S, Liao J, Mu Y, Xiao L.   +8 more
europepmc   +1 more source

Microparticle-induced release of B-lymphocyte regulators by rheumatoid synoviocytes [PDF]

, 2009
Laurent Messer, Ghada Alsaleh, Jean-Marie Freyssinet, Fatiha Zobairi, Isabelle Leray, Jacques-Eric Gottenberg, Jean Sibilia, Florence Toti-Orfanoudakis, Dominique Wachsmann   +8 more
core   +1 more source