Results 121 to 130 of about 18,476 (229)

Effect of Interleukin‐6 Inhibitors on Rheumatoid Arthritis Pain: Overview of Evidence and Mechanistic Pathways

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
This review synthesizes current mechanistic and clinical evidence on IL‐6 inhibitors, particularly sarilumab and tocilizumab, concerning their effect on pain in RA. ABSTRACT Rheumatoid arthritis (RA) is an autoimmune systemic disease in which pain remains a major and often refractory symptom even after clinical remission of the disease.
Andrej Belančić, Seher Sener, Almir Fajkić, Ines Potočnjak, Mirjana Stanić Benić, Marijana Vučković, Yusuf Ziya Sener, Marija Rogoznica Pavlović, Antonio Markotić, Josipa Radić, Mislav Radić   +10 more
wiley   +1 more source

Synovial cell metabolism and chronic inflammation in rheumatoid arthritis [PDF]

, 2018
Metabolomic studies of body fluids show that immune-mediated inflammatory diseases such as rheumatoid arthritis (RA) are associated with metabolic disruption.
Buckley, CD, Clark, AR, Falconer, Jane, Guma, M, Murphy, AN, Tiziani, S, Young, SP   +6 more
core  

The Role of Neuritin 1 in Synaptic Plasticity and Sensory Nerve Function: Integrator of Neurotrophic, Metabolic and Injury Signals

European Journal of Neuroscience, Volume 63, Issue 7, April 2026.
Neuritin 1 (NRN1) is a multifaceted regulator of synaptic plasticity, neuronal excitability and structural remodelling, acting as a molecular integrator of neurotrophic, metabolic and injury‐associated signals that coordinate adaptive plasticity.
Jyoti Agrawal, Mar Vives Escola, Simon W. Jones, Victoria Chapman, Federico Dajas‐Bailador   +4 more
wiley   +1 more source

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

Fibrotic pathways and fibroblast-like synoviocyte phenotypes in osteoarthritis

Frontiers in Immunology
Osteoarthritis (OA) is the most common form of arthritis, characterized by osteophyte formation, cartilage degradation, and structural and cellular alterations of the synovial membrane. Activated fibroblast-like synoviocytes (FLS) of the synovial membrane have been identified as key drivers, secreting humoral mediators that maintain inflammatory ...
Alexandra Damerau, Alexandra Damerau, Emely Rosenow, Dana Alkhoury, Frank Buttgereit, Frank Buttgereit, Timo Gaber, Timo Gaber   +7 more
openaire   +3 more sources

The Crosstalk Mechanisms Between Ferroptosis and Pyroptosis and Their Applications in Diseases: From Molecular Networks to Clinical Strategies

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Ferroptosis and pyroptosis are two distinct forms of regulated cell death that play crucial roles in cancer, neurodegeneration, and inflammatory diseases. Ferroptosis is characterised by iron‐dependent lipid peroxidation, while pyroptosis is an inflammatory cell death mediated by gasdermin proteins.
Wei‐Yi Zhao, Lu‐yao Li, Fang‐wang Ye, Jin‐Wei Zhao   +3 more
wiley   +1 more source

Schwann Cell TRPA1, a Proalgesic Ion Channel, Mediates Neuroinflammation and Fibromyalgia‐Associated Behaviours in Mice

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Cellular and molecular mechanisms contributing to TRPA1‐mediated mechanical and cold hypersensitivity and peripheral neuroinflammation in the reserpine‐induced experimental fibromyalgia model. (1) Macrophage‐originated reactive oxygen species (ROS; purple dots) target the transient receptor potential ankyrin 1 (TRPA1) channel localised in Schwann cells.
Evelyne Silva Brum, Maria Fernanda Pessano Fialho, Daniel Souza Monteiro de Araújo, Lorenzo Landini, Matilde Marini, Francesco De Logu, Romina Nassini, Sara Marchesan Oliveira   +7 more
wiley   +1 more source

Adrenal Steroids Modulate Fibroblast-Like Synoviocytes Response During B. abortus Infection

Frontiers in Endocrinology, 2019
Brucella abortus stimulates an inflammatory immune response that stimulates the endocrine system, inducing the secretion of dehydroepiandrosterone (DHEA) and cortisol. In humans, the active disease is generally present as osteoarticular brucellosis.
María Virginia Gentilini, Guillermo Hernán Giambartolomei, María Victoria Delpino   +2 more
doaj   +1 more source

Collagen organisation in the fibrous joint capsules in the digits of the human hand

Journal of Anatomy, Volume 248, Issue 4, Page 612-623, April 2026.
The function of the finger joints is important for daily life. In this review of the literature, we consider the role of collagen and its organization within the fibrous finger joint capsules of the interphalangeal (IP) joints and investigate the relationships between collagen orientation and joint function. Abstract Normal function of the hand and, in
Fiona R. Saunders, Ronald G. Coutts, Richard M. Aspden, Flora Gröning   +3 more
wiley   +1 more source

Immunological Roles of Fibroblast-Like Synoviocyte Cells in Rheumatoid Arthritis [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Fibroblast-like synoviocytes (FLS), also known as synovial fibroblasts or type B synoviocytes, are the primary cells responsible for the structure of the synovial lining.
Mohammad Reza Royaei, Mohammad Taher Tahoori   +1 more
doaj