Results 101 to 110 of about 4,822,589 (177)

CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis

Journal of Orthopaedic Translation
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and bone destruction. Abnormal TNF/TNFR signaling leads to various dysregulations in Fibroblast-like synoviocytes (FLSs), including proliferation,
Xiaomeng Luo, Lingling Xu, Juan Cai, Siyang Ma, Haining Song, Pingting Yang, Chunshu Yang   +6 more
doaj   +1 more source

Enhancing the effectiveness of immunotherapy in rheumatoid arthritis by delaying immunosenescence triggered by fibroblast-like synoviocytes

Rheumatoid arthritis (RA) is a prevalent autoimmune disorder primarily targeting the diarthrodial joints. During the progression of RA, fibroblast-like synoviocytes (FLSs) exhibit tumor-like behavior, including increased proliferation, inflammation ...
Yang Luo, Hai-Li Shen, Li Zhang
core   +1 more source

Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain. [PDF]

Inflammation is associated with localized acidosis, however, attributing physiological and pathological roles to proton-sensitive receptors is challenging due to their diversity and widespread expression. Here, agonists of the proton-sensing GPCR, GPR65,

core   +2 more sources

Image_1_PSTPIP2 Inhibits the Inflammatory Response and Proliferation of Fibroblast-Like Synoviocytes in vitro.TIF

, 2018
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease and its pathogenesis remains unclear. Fibroblast-like synoviocytes (FLSs) play an important role in the pathogenesis of RA. Proline-serine-threonine phosphatase interacting protein 2 (
Jun Li (6494), Xiaoming Meng (596750), Yaru Liu (2394562), Yao Yao (335996), Xiaofeng Li (342614), Haixia Yu (2519266), Cheng Huang (115619), Qingqing Xu (465549)   +7 more
core   +1 more source

Synovial inflammation and immune-stromal crosstalk in osteoarthritis-related synovial fibroblast research, 2006–2025: a bibliometric analysis

Frontiers in Immunology
BackgroundOsteoarthritis (OA) is increasingly understood as a whole-joint organ disease involving cartilage, synovium, subchondral bone, and the local immune-stromal microenvironment.
Tiange Xia, Tiange Xia, Xiaoyan Sun, Xiaoyan Sun, Zhiwei Jiang, Zhiwei Jiang, Yijie Zhang, Yijie Zhang, Yi Zhou, Yi Zhou, Yang Shao, Shaoshuo Li, Jianwei Wang   +12 more
doaj   +1 more source

Image_2_PSTPIP2 Inhibits the Inflammatory Response and Proliferation of Fibroblast-Like Synoviocytes in vitro.TIF

, 2018
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease and its pathogenesis remains unclear. Fibroblast-like synoviocytes (FLSs) play an important role in the pathogenesis of RA. Proline-serine-threonine phosphatase interacting protein 2 (
Jun Li (6494), Xiaoming Meng (596750), Yaru Liu (2394562), Yao Yao (335996), Xiaofeng Li (342614), Haixia Yu (2519266), Cheng Huang (115619), Qingqing Xu (465549)   +7 more
core   +1 more source

An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast‐Like Synoviocytes by Encapsulation in a Chitosan‐Based Hydrogel

Osteoarthritis (OA) and Rheumatoid arthritis (RA) are the most common arthritis in which the synovium is involved, but the cellular and molecular basis of these pathologies still need better elucidation.
Scalera, Francesca, Corallo, Gaia, Gigli, Giuseppe, Bisconti, Francesco, Chiocchetti, Annalisa, Polini, Alessandro, Vilardo, Beatrice, Gervaso, Francesca   +7 more
core   +1 more source

Progesterone Modulates Protein Synthesis in Osteoarthritic Fibroblast-like Synoviocytes. [PDF]

Int J Mol Sci
Askar F, Chatziagorou G, Wüstenhagen S, Capraro A, Andersson B, Berger E, Esposito D, Labusca L, Corciulo C.   +8 more
europepmc   +1 more source

Artemisinin increases susceptibility to ferroptosis of fibroblast-like synoviocytes in rheumatoid arthritis. [PDF]

Arthritis Res Ther
Li M, Wang J, Yu Y, Wang L, Lu F, Li S, Wang J, Liu Y, Yin G, Xu C, Wang Y.   +10 more
europepmc   +1 more source

Itaconate reduces proliferation and migration of fibroblast-like synoviocytes and ameliorates arthritis models

Fibroblast-like synoviocytes (FLS) play critical roles in rheumatoid arthritis (RA). Itaconate (ITA), an endogenous metabolite derived from the tricarboxylic acid (TCA) cycle, has attracted attention because of its anti-inflammatory, antiviral, and ...
Amengual, Olga, Shimizu, Tomohiro, Kono, Michihito, Takeyama, Shuhei, Ishizu, Hotaka, Fujieda, Yuichiro, Kudo, Yuki, Iwasaki, Norimasa, Atsumi, Tatsuya, Kanda, Masatoshi, Kato, Masaru, Hisada, Ryo, Tada, Maria, Sakiyama, Kodai, Endo, Tsutomu   +14 more
core   +1 more source