Results 81 to 90 of about 4,822,589 (177)

Effects of pulsed electromagnetic field exposure on adenosine receptors in human fibroblast-like synoviocytes.

, 2011
Human fibroblast-like synoviocytes play a central role in the pathogenesis of joint destruction primarily by the secretion of a wide range of pro-inflammatory mediators including cytokines, growth factors and lipid mediators of inflammation.
Cadossi P.A., TARGA, Martina, MASSARI, Leo, BOREA, Pier Andrea, VINCENZI, Fabrizio, MASIERI, Federica Francesca, VARANI, Katia, ONGARO, Alessia, DE MATTEI, Monica, Setti S.   +9 more
core  

The LKB1–AMPK Signaling Axis Modulates Ferroptosis in Fibroblast-Like Synoviocytes Derived from Rheumatoid Arthritis

Biomedicines
Background/Objectives: Ferroptosis is a type of regulated cell death that involves iron-dependent accumulation of lipid peroxides. Because fibroblast-like synoviocytes (FLSs) in patients with rheumatoid arthritis (RA) have a hyperplastic and inflammatory
Ha-Reum Lee, Su-Jin Yoo, Jinhyun Kim, Seong Wook Kang   +3 more
doaj   +1 more source

Single‐Cell Analysis of Cartilage‐Derived Cells Identifies Diverse Populations and a Cholesterol/ER‐Stress Chondrocyte Subset in Knee OA

Journal of Orthopaedic Research, Volume 44, Issue 10, October 2026.
ABSTRACT This study aimed to elucidate the cellular and molecular mechanisms underlying knee osteoarthritis pathogenesis by analyzing chondrocyte populations and their spatial distribution using single‐cell RNA sequencing (scRNA‐seq). Knee cartilage cells underwent scRNA‐seq.
Yu Kobori, Kohei Nishitani, Hiroyuki Yoshitomi, Akinori Murakami, Kazuki Ichiyanagi, Shigeo Yoshida, Jiu Tanaka, Shinichi Kuriyama, Shinichiro Nakamura, Akio Sakamoto, Takashi Noguchi, Yugo Morita, Takashi Sono, Takayuki Fujii, Koichi Murata, Junya Toguchida, Hideki Ueno, Yasuhiro Murakawa, Chikashi Terao, Shuichi Matsuda   +19 more
wiley   +1 more source

Differential effects of anti-TNF-alpha drugs on fibroblast-like synoviocyte apoptosis

, 2010
Novel drugs targeting TNF-alpha are available for treatment of RA. Fibroblast-like synoviocytes (FLSs) play a fundamental role in RA progression, through their expansion caused in part by resistance to cell death induction.
Casali, Bruno, SALVARANI, CARLO, Boiardi, Luigi, Pattacini, Laura   +3 more
core   +1 more source

mRNA expression of genes involved in inflammation and haemostasis in equine fibroblast-like synoviocytes following exposure to lipopolysaccharide, fibrinogen and thrombin [PDF]

, 2015
Background: Studies in humans have shown that haemostatic and inflammatory pathways both play important roles in the pathogenesis of joint disease. The aim of this study was to assess mRNA expression of haemostatic and inflammatory factors in cultured ...
Stine Jacobsen, Stine Mandrup Andreassen, Jacobsen, Stine, Andreassen, Stine Mandrup, Lise C. Berg, Søren Saxmose Nielsen, Annemarie T. Kristensen, Berg, Lise Charlotte, Nielsen, Søren Saxmose, Kristensen, Annemarie Thuri   +9 more
core   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, Volume 40, Issue 10, Page 6005-6042, October 2026.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Osteoarthritis Therapeutics: From Microenvironment Understanding to Regenerative Intervention—Current Advances and Future Perspectives

Orthopaedic Surgery, Volume 18, Issue 10, Page 2032-2044, October 2026.
This article outlines a paradigm shift in OA therapeutics, OA as a systemic disease of joint microenvironment imbalance. It synthesizes advances in targeting key pathological hubs—immune, metabolic, and senescent—and details novel regenerative strategies using engineered biomaterials and exosomes.
Yongbiao Meng, Shenghua Wu, Quanchun Liu
wiley   +1 more source

SPA0355, a thiourea analogue, inhibits inflammatory responses and joint destruction in fibroblast‐like synoviocytes and mice with collagen‐induced arthritis

, 2011
BACKGROUND AND PURPOSE NF-kappa B has been implicated as a therapeutic target for the treatment of rheumatoid arthritis. We previously synthesized a thiourea analogue, SPA0355, which suppressed NF-kappa B activity.
YJ Cheon, JH Ryu, BH Park, Lee, H. S., HS Lee, SM Lee, Cheon, Y. J., Lee, Y. R., Park, J. W., Hwang, J. K., Lee, S. I., Jeon, R., SI Lee, Kwak, H. B., JW Park, YR Lee, HB Kwak, R Jeon, Park, B. H., Ryu, J. H., Lee, S. M., JK Hwang, JS Kim, Kim, J. S.   +23 more
core   +1 more source

The Effects of MicroRNAs on Key Signalling Pathways and Epigenetic Modification in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis

, 2018
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level via direct binding to the 3′-untranslated region (UTR) of target mRNAs.
Wenming Hong, Pengying Zhang, Xinming Wang, Wei Wei, Jiajie Tu   +4 more
core   +2 more sources