Results 61 to 70 of about 18,476 (229)

TRIM32 promotes inflammatory responses in rheumatoid arthritis fibroblast‐like synoviocytes [PDF]

Scandinavian Journal of Immunology, 2020
AbstractRheumatoid arthritis (RA) is a worldwide autoimmune disease. The study of its aetiology and mechanism has always been a focus topic in medicine. This research was designed to investigate the effect of E3 ubiquitin ligase tripartite motif protein 32 (TRIM32) in rheumatoid arthritis (RA).
Tian Liang, Min Song, Kewu Xu, Chenglong Guo, Hongbin Xu, Hongwei Zhang, Lanping Xu   +6 more
openaire   +2 more sources

LncRNA linc00152/NF‐κB feedback loop promotes fibroblast‐like synovial cells inflammation in rheumatoid arthritis via regulating miR‐103a/TAK1 axis and YY1 expression

Immunity, Inflammation and Disease, 2021
Introduction: Overexpressed inflammatory cytokines are the main factors causing rheumatoid arthritis (RA) tissue damage and pathological deterioration, and lncRNAs has found to beinvolved in some autoinflammatory diseases. Methods: We designed this study
Jian Zhang, Fei‐Fei Gao, Jie Xie
doaj   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages

EBioMedicine, 2018
Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being the macrophage.MVs were generated ...
Hefin I. Rhys, Francesco Dell'Accio, Costantino Pitzalis, Adrian Moore, Lucy V. Norling, Mauro Perretti   +5 more
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Biological Effects of Phosphate on Fibroblast-Like Synoviocytes [PDF]

ISRN Cell Biology, 2012
This study sought to examine the expression of genes implicated in phosphate transport and pathological calcification in osteoarthritis (OA) and rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) and investigate the biological effects of phosphate.
Yubo Sun, David R. Mauerhan, Deepthi Chaturvedi, Edward N. Hanley, Helen E. Gruber   +4 more
openaire   +1 more source

Complete Freund’s Adjuvant Induces a Fibroblast-like Synoviocytes (FLS) Metabolic and Migratory Phenotype in Resident Fibroblasts of the Inoculated Footpad at the Earliest Stage of Adjuvant-Induced Arthritis

Cells, 2023
The fibroblast-like synoviocytes (FLS) have a crucial role in the pathogenesis of Rheumatoid Arthritis (RA); however, its precise mechanisms remain partially unknown. The involvement of the fibroblast in activating adjuvant-induced arthritis (AA) has not
Susana Aideé González-Chávez, Eduardo Chaparro-Barrera, María Fernanda Alvarado-Jáquez, Rubén Cuevas-Martínez, Rosa Elena Ochoa-Albíztegui, César Pacheco-Tena   +5 more
doaj   +1 more source

Different expression of [béta] subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes [PDF]

, 2016
K
Beeton, Christine, Gulko, Pércio S., Huq, Redwan, Laragione, Teresina, Panyi, György, Pethő, Zoltán, Tajhya, Rajeev B., Tanner, Mark R.   +7 more
core   +2 more sources

The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart

Animal Models and Experimental Medicine, EarlyView.
The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang, Haifeng Jiang, Zhen Xu, Tingyu Dong, Xiaoyi Liu, Shangxue Yan, Jiajie Kuai, Yan Chang, Wei Wei   +8 more
wiley   +1 more source

Regulation of JNK by MKK‐7 in fibroblast‐like synoviocytes [PDF]

Arthritis & Rheumatism, 2006
AbstractObjectiveJNK regulates matrix metalloproteinase (MMP) gene expression and joint destruction in rheumatoid arthritis (RA). Previous studies demonstrated that the 2 upstream MAPK kinases (MKK‐4 and MKK‐7) are phosphorylated in RA synovium and form a complex with JNK in fibroblast‐like synoviocytes (FLS). However, the functional hierarchy of MKK‐4
Tomoyuki, Inoue, Deepa, Hammaker, David L, Boyle, Gary S, Firestein   +3 more
openaire   +2 more sources