Results 61 to 70 of about 4,822,589 (177)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

MAFF is a critical mediator of TNF-α-induced NF-κB activation and aggressive phenotype in rheumatoid arthritis synoviocytes

European Journal of Medical Research
Background Rheumatoid arthritis (RA) is a chronic immune-mediated synovial disease in which fibroblast-like synoviocytes (FLSs) exhibit a tumor-like phenotype that drives cartilage erosion and inflammation. Although MAF BZIP Transcription Factor F (MAFF)
Lijuan Qiu, Yazhu Xu, Tong Zhang, An Wan, Jinhui Tao   +4 more
doaj   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Regulation of proliferation, migration, invasion, and apoptosis in LPS-induced fibroblast-like synoviocytes by astragalus polysaccharide via the EGFR/MAPK signaling pathway

Bangladesh Journal of Pharmacology
This study investigated the effects of astragalus polysaccharides on prolifer-ation, apoptosis, migration, invasion, and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) signaling pathway in human rheumatoid arthritis ...
Bing-Jun Zhu, Ping Luo, Yin-Hua Peng, Yin-Chun Zhu   +3 more
doaj   +1 more source

A Cryopreservation‐Based Supply Chain Strategy for Extrusion Bioprinting in Space

Advanced Materials Technologies, Volume 11, Issue 20, 21 October 2026.
Extrusion bioprinting on crewed space platforms requires a bioink that stays functional along the logistic chain. Here, cells and biomaterial ink travel separately, the cells cryopreserved and the ink cold stored, and are combined only minutes before printing.
Johannes Windisch, Max von Witzleben, Richard Frank Richter, Finn Dani, Constantin Greil, Sarah Duin, Anja Lode, Michael Gelinsky   +7 more
wiley   +1 more source

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

Nature Communications, 2016
Rheumatoid arthritis is an inflammatory disease that selectively affects different joints. Here the authors show that gene expression and DNA methylation patterns of fibroblast-like synoviocytes differ between hip and knee joints in patients with RA ...
Rizi Ai, Deepa Hammaker, David L. Boyle, Rachel Morgan, Alice M. Walsh, Shicai Fan, Gary S. Firestein, Wei Wang   +7 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, Volume 78, Issue 10, Page 2074-2081, October 2026.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source

Regulatory Fibroblast‐Like Synoviocytes Cell Membrane Coated Nanoparticles: A Novel Targeted Therapy for Rheumatoid Arthritis

, 2023
Fibroblast‐like synoviocytes (FLS) are the main cell component in the inflamed joints of patients with rheumatoid arthritis (RA). FLS intimately interact with infiltrating T cells.
Jingying Lan, Yuan Liu, Yesi Shi, Rongjuan Chen, Guixiu Shi, Dan Mu, Shiju Chen, Peishi Rao, Xinwei Zhang, Gang Liu, Hongyan Qian, Chaoqiong Deng   +11 more
core   +1 more source

Anti‐Inflammatory Effects of Vicatia thibetica De Boiss. in Rheumatoid Arthritis and Associated Multi‐Pathway Modulation In Vivo

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Vicatia thibetica de Boiss. (VTDB) extracts and fractions were screened for anti‐rheumatoid arthritis activity via UHPLC‐MS, network pharmacology, and CIA rat models. VTDB‐nBuOH stood out, regulating PI3K/Akt, JAK2/STAT3, macrophage polarization, and gut microbiota to relieve joint inflammation, with proteomics verifying its multi‐pathway regulatory ...
Mo‐Zi‐Li Adu, Wei Jiang, Min Li, Bo‐Wei Xia, En Yuan, Yue‐Zhi Tan, Wu‐Xin Yang, Guo‐Yue Zhong, Qin‐Ge Ma, Rong‐Rui Wei   +9 more
wiley   +1 more source