Results 71 to 80 of about 4,822,589 (177)

Pharmacological characterization of purine receptors in bovine fibroblast-like synoviocytes

, 2009
Growing evidence also suggests that extracellular nucleotides, acting through purinergic receptors, play a central role in the regulation of bone and cartilage metabolism.
GESSI, Stefania, CARUSO, Angelo, BOREA, Pier Andrea, VINCENZI, Fabrizio, VARANI, Katia, DE MATTEI, Monica, MERIGHI, Stefania   +6 more
core  

tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis [PDF]

, 2004
Abnormalities in the p53 tumor suppressor gene have been detected in rheumatoid arthritis (RA) and could contribute to the pathogenesis of chronic disease.
Alison Connor, Green, Douglas R, Zollman, Susan, Connor, Alison, Yuji Yamanishi, Gary S Firestein, Susan Zollman, Douglas R Green, Edward C Keystone, Firestein, Gary S, Keystone, Edward C, David L Boyle, Boyle, David L, Yamanishi, Yuji   +13 more
core   +1 more source

Joint Location–Specific JAK‐STAT Signaling in Rheumatoid Arthritis Fibroblast‐like Synoviocytes

ACR Open Rheumatology, 2019
Objective Rheumatoid arthritis (RA) fibroblast‐like synoviocytes (FLS) derived from hip and knee have distinctive DNA methylation and transcriptome patterns in interleukin (IL)‐6 signaling and Janus kinase (JAK)–signal transducers and activators of ...
Deepa Hammaker, Gyrid Nygaard, Amanda Kuhs, Rizi Ai, David L. Boyle, Wei Wang, Gary S. Firestein   +6 more
doaj   +1 more source

Tomatidine Exposure During Early Myogenesis Promotes Hypertrophy of C2C12 Muscle Cells Through Increased Nuclei Accretion

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT During myogenesis or myofiber regeneration, a proliferating muscle cell must leave the cell cycle, commit to differentiate, and fuse to neighboring myoblasts to create multinucleated myotubes, and eventually mature myofibers. These stages can be manipulated by exogenous factors including signaling molecules, mechanical cues, and nutrient ...
Marissa K. Caldow, Kristy Swiderski, John H. V. Nguyen, Emily S. Haber, Kyla J. H. Fritz, Gordon S. Lynch   +5 more
wiley   +1 more source

PHARMACOLOGICAL CHARACTERIZATION OF P2X1 AND P2X3 PURINERGIC RECEPTORS IN BOVINE CHONDROCYTES AND FIBROBLAST-LIKE SYNOVIOCYTES

, 2009
Extracellular nucleotides, acting through purinergic receptors, play a central role in the regulation of bone and cartilage metabolism. Chondrocytes within articular cartilage are responsible for the synthesis and degradation of the extracellular matrix,
TOSI, ALICE, GESSI, Stefania, BOREA, Pier Andrea, VINCENZI, Fabrizio, PELLATI, Agnese, VARANI, Katia, MERIGHI, Stefania, DE MATTEI, Monica   +7 more
core  

Effect of Miao medicine, Jinwujiangu decoction, on IL- 17/IL-23 inflammatory axis of fibroblast-like synoviocytes in rheumatoid arthritis [PDF]

, 2019
Purpose: To explore the influence of the Miao medicine, Jinwujiangu decoction, on the interleukin (IL)- 17/IL-23 inflammatory axis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA).Methods: Synovial tissue samples were randomly divided ...
Ning, Qiaoyi, Li, Rong, Lu, Daoming, Ma, Wukai, An, Yang, Yao, Xueming, Liang, Jiang, Huang, Ying, Xu, Hui, Tang, Fang   +9 more
core   +1 more source

After delivery: How recipient cells shape the fate and function of transplanted mitochondria

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Recipient‐cell handling shapes how transplanted mitochondria contribute after delivery, linking donor competence, recipient state and exposure duration to intracellular fate. The framework matches transient rescue, sustained functional support and durable mitochondrial DNA correction to the evidence and product attributes required for each therapeutic ...
Zhi‐Yuan Zhang, Bo‐Quan Qin, Shi‐Zhou Wu, Hui Zhang   +3 more
wiley   +1 more source

Mitomycin C Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via a Mitochondrial-Mediated Pathway [PDF]

, 2015
Background/Aims: Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterised by prominent synoviocyte hyperplasia and a potential imbalance between the growth and death of fibroblast-like synoviocytes (FLS).
Xiaojian Cao, Changhui Su, Chuqi Yan, Dong Ge, Xishan Zhang, Chuqi Yan, Yanming Zhang, Dechao Kong   +7 more
core   +1 more source

XuanBi Mitigates Rheumatoid Arthritis via Regulation of ECM‐Receptor Interactions and IL‐17 Signaling: Insights From Integrated Proteomic and Pharmacological Analyses

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
The anti‐inflammatory effect of XuanBi Herbal Formula was evaluated in arthritic rat models, in which suppression of synovial inflammation was observed. The chemical ingredients of XuanBi were detected in both the decoction and rat peripheral blood. Potential targets of the formula were then intersected with previous synovial proteomic data, through ...
Hao Zhu, Zhenfeng Pan, Ying Lu, Ping Xia, Weiming He, Jingqi Zeng, Fan Wang, Xiao Liu, Minggang Wei   +8 more
wiley   +1 more source

Computational Prediction of the Therapeutic Mechanisms From the Turmeric‐Pueraria‐Coix Seed Botanical Formula in Rheumatoid Arthritis

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Overview of the integrated computational framework used to investigate the Turmeric–Pueraria–Coix seed formula in rheumatoid arthritis. Phytochemical and disease‐associated targets were integrated with ferroptosis and oxidative‐stress genes, multicohort transcriptomics, machine learning, structural modeling, and single‐cell in silico perturbation to ...
Weiya Lan, Qianwei Lu, Xudong Rui, Ke Li, Chaoji Su, Qiang Su, Yanchang Huang, Run Shi, Wei Chen, Fang Tang   +9 more
wiley   +1 more source