Results 11 to 20 of about 542,085 (295)

Developmentally regulated expression of integrin alpha-6 distinguishes neural crest derivatives in the skin

Frontiers in Cell and Developmental Biology, 2023
Neural crest-derived cells play essential roles in skin function and homeostasis. However, how they interact with environmental cues and differentiate into functional skin cells remains unclear.
Shize Ma, Shize Ma, Xiu Li, Xiu Li, Rui Cao, Rui Cao, Guoqin Zhan, Guoqin Zhan, Xin Fu, Xin Fu, Ran Xiao, Ran Xiao, Zhigang Yang, Zhigang Yang   +13 more
doaj   +1 more source

Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry

Biomedicines, 2022
Background: Atrial fibroblasts activation causes atrial fibrosis, which is one major pathophysiological contributor to atrial fibrillation (AF) genesis.
Yuan Hung, Cheng-Chih Chung, Yao-Chang Chen, Yu-Hsun Kao, Wei-Shiang Lin, Shih-Ann Chen, Yi-Jen Chen   +6 more
doaj   +1 more source

Understanding Fibroblast Heterogeneity in Form and Function

Biomedicines, 2023
Historically believed to be a homogeneous cell type that is often overlooked, fibroblasts are more and more understood to be heterogeneous in nature. Though the mechanisms behind how fibroblasts participate in homeostasis and pathology are just beginning
Jennifer B. Parker, Caleb Valencia, Deena Akras, Sarah E. DiIorio, Michelle F. Griffin, Michael T. Longaker, Derrick C. Wan   +6 more
doaj   +1 more source

Functional roles of CD26/DPP4 in bleomycin‐induced pulmonary fibrosis

Physiological Reports, 2023
The pathogenesis of pulmonary fibrosis involves complex interplay between cell types and signaling pathways. Recurrent alveolar epithelial injury can occur during pulmonary inflammation, causing dysregulation of epithelial repair.
Yu Koyanagi, Takeshi Kawasaki, Yoshitoshi Kasuya, Ryo Hatano, Shun Sato, Yukiko Takahashi, Kei Ohnuma, Chikao Morimoto, Steven M. Dudek, Koichiro Tatsumi, Takuji Suzuki   +10 more
doaj   +1 more source

CVD and COVID-19: Emerging Roles of Cardiac Fibroblasts and Myofibroblasts

Cells, 2022
Cardiovascular disease (CVD) is the leading cause of death worldwide. Current data suggest that patients with cardiovascular diseases experience more serious complications with coronavirus disease-19 (COVID-19) than those without CVD. In addition, severe
Laxmansa C. Katwa, Chelsea Mendoza, Madison Clements   +2 more
doaj   +1 more source

Lysine-Specific Demethylase 4D Is Critical for the Regulation of the Cell Cycle and Antioxidant Capacity in Goat Fibroblast Cells

Biology, 2023
Oxidative damage to skin fibroblast cells is a causative factor in many skin diseases. Previous studies have reported that lysine-specific demethylase 4D (Kdm4d) is involved in DNA replication, but its role on antioxidant capacity remains unclear. In the
Xiaowei Chen, Yingnan Yang, Yu Cai, Hua Yang, Feng Wang, Mingtian Deng   +5 more
doaj   +1 more source

Construction of a Fibroblast-Associated Tumor Spheroid Model Based on a Collagen Drop Array Chip

Biosensors, 2021
Spheroid, a 3D aggregate of tumor cells in a spherical shape, has overcome the limitations of conventional 3D cell models to accurately mimic the in-vivo environment of a human body.
Hyewon Roh, Hwisoo Kim, Je-Kyun Park
doaj   +1 more source

Extracellular CIRP Induces an Inflammatory Phenotype in Pulmonary Fibroblasts via TLR4

Frontiers in Immunology, 2021
Extracellular cold-inducible RNA-binding protein (eCIRP), a new damage-associated molecular pattern (DAMP), has been recently shown to play a critical role in promoting the development of bleomycin-induced pulmonary fibrosis.
Siavash Bolourani, Siavash Bolourani, Siavash Bolourani, Ezgi Sari, Max Brenner, Max Brenner, Max Brenner, Max Brenner, Ping Wang, Ping Wang, Ping Wang, Ping Wang   +11 more
doaj   +1 more source

KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes’ phenotypes

Frontiers in Immunology
BackgroundHuntingtin-interacting protein-1 (HIP1) is a new arthritis severity gene implicated in the regulation of the invasive properties of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS).
Teresina Laragione, Carolyn Harris, Percio S. Gulko   +2 more
doaj   +1 more source

Efeito do número da passagem e do gênero das células doadoras de núcleo no desenvolvimento de bovinos produzidos por transferência nuclear Effect of culture time and gender of nuclei donor cells on bovine development produced by nuclear transfer

Revista Brasileira de Zootecnia, 2010
Objetivou-se com este trabalho avaliar o efeito do número da passagem e do sexo das células doadoras de núcleo no desenvolvimento embrionário e fetal após transferência nuclear.
Giovana Krempel Fonseca Merighe, Moysés dos Santos Miranda, Tiago Henrique Câmara de Bem, Yeda Fumie Watanabe, Flávio Vieira Meirelles   +4 more
doaj   +1 more source