Results 31 to 40 of about 510,893 (315)
The FASEB Journal, 2023 AbstractG protein‐coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors. GPCRs regulate many functions in the human body and have earned the title of “most targeted receptors”. About one‐third of the commercially available drugs for various diseases target the GPCRs.
Nidhi V. Dwivedi +6 more
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Fibroblastic sarcomas of the mediastinum [PDF]
Mediastinum, 2020 Primary mediastinal fibroblastic sarcomas constitute a rare, heterogeneous group of neoplasms, mainly including solitary fibrous tumor (SFT) (benign and malignant), low grade fibromyxoid sarcoma (LGFMS), adult fibrosarcoma (FS), myxofibrosarcoma, sclerosing epithelioid FS, etc. Although morphologically diverse, they frequently have similar clinical and
Chen, Shaoxiong, Badve, Sunil S.
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Journal of Functional Biomaterials, 2016 A photocrosslinkable trehalose derivative carrying mesogenic groups was synthesized by esterification reactions. The derivative (TC-HBPHA) was synthesized by the reaction of partially cinnamoyl-modified trehalose (TC4) with 4-(4-hexyloxybenzoyloxy ...
Shinya Yano +3 more
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Regulatory T Cells in Chronic Heart Failure
Frontiers in Immunology, 2021 Heart failure is a global problem with high hospitalization and mortality rates. Inflammation and immune dysfunction are involved in this disease. Owing to their unique function, regulatory T cells (Tregs) have reacquired attention recently.
Yuzhi Lu +5 more
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Frontiers in Pharmacology, 2020 In recent years target based drug discovery has expanded our therapeutic armamentarium in the treatment of inflammatory and autoimmune diseases. Despite these advances and adverse effects, glucocorticoids remain reliable agents that are used in many of ...
Tadashi Hosoya +11 more
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The Role of the Inflammasome in Heart Failure
Frontiers in Physiology, 2021 Inflammation promotes the development of heart failure (HF). The inflammasome is a multimeric protein complex that plays an essential role in the innate immune response by triggering the cleavage and activation of the proinflammatory cytokines ...
Jimin Wu +15 more
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“There will be blood” from fibroblasts [PDF]
Cell Cycle, 2013 The blood system is continuously replenished from a rare population of hematopoietic stem cells (HSCs) that balance self-renewal and differentiation.1 It is believed that HSCs emerge during embryog...
Ihor R. Lemischka +2 more
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Frontiers in Oncology, 2022 In prostate cancer (PCa), a characteristic stromal–epithelial redistribution of the membrane protein caveolin 1 (CAV1) occurs upon tumor progression, where a gain of CAV1 in the malignant epithelial cells is accompanied by a loss of CAV1 in the tumor ...
Alina Wittka +6 more
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Deciphering cancer fibroblasts [PDF]
Journal of Experimental Medicine, 2018 In this issue of JEM, Raz et al. (https://doi.org/10.1084/jem.20180818) identify a subset of bone marrow–derived cells that uniquely promotes breast cancer angiogenesis and tumor growth. The existence of functional heterogeneity among stromal populations motivates further fundamental and therapeutic inquiries.
Giulia Biffi, David A. Tuveson
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Origins of Cardiac Fibroblasts [PDF]
Circulation Research, 2010 Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms.
Zeisberg, Elisabeth M., Kalluri, Raghu
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