Results 31 to 40 of about 1,131,844 (424)
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
Communications Biology, 2020 Fibroblasts are an essential cell population for human skin architecture and function. While fibroblast heterogeneity is well established, this phenomenon has not been analyzed systematically yet.
Llorenç Solé-Boldo +7 more
semanticscholar +1 more source
bioRxiv, 2021 Pro-inflammatory fibroblasts are critical to pathogenesis in rheumatoid arthritis, inflammatory bowel disease, interstitial lung disease, and Sjögren’s syndrome, and represent a novel therapeutic target for chronic inflammatory disease.
I. Korsunsky +24 more
semanticscholar +1 more source
Molecular Oncology, 2023 Pancreatic ductal adenocarcinoma (PDAC) is marked by molecular heterogeneity and poor prognosis. Among the stemness‐related transcription factors, Spalt‐like Transcription Factor 4 (SALL4) is correlated with unfavorable outcomes; however, its roles in ...
Angélique Vienot +13 more
doaj +1 more source
Fibroblast pathology in inflammatory diseases.
Journal of Clinical Investigation, 2021 Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on different roles (a) as inflammatory cells themselves and (b) in ...
Kevin Wei, Hung N. Nguyen, M. Brenner
semanticscholar +1 more source
Frontiers in Pharmacology, 2019 Exposure to insoluble particles in the lung elicits inflammatory responses that eliminate deposited particulates and repair damaged tissue. Overzealous or prolonged responses lead to chronic conditions, such as fibrosis and malignancy, which are ...
Jie Dong, Qiang Ma
doaj +1 more source
The effect of helper virus on Abelson virus-induced transformation of lymphoid cells [PDF]
, 1978 Abelson murine leukemia virus (A-MuLV)-transformed fibroblast nonproducer cells were used to prepare A-MuLV stocks containing a number of different helper viruses.
Baltimore, David, Rosenberg, Naomi
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Cardiac Fibrosis and Fibroblasts [PDF]
Cells, 2021 Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen. Myofibroblasts are major players in the production of collagen, and are differentiated primarily from resident fibroblasts. Collagen can compensate for the dead cells produced by injury.
openaire +3 more sources
Frontiers in Genetics, 2022 Immortalized cell lines are valuable resources to expand the molecular characterization of major histocompatibility complex genes and their presented antigens.
Quy Van Chanh Le +6 more
doaj +1 more source
Teflon Injection into the Trachea Causes Predictable Fibroblastic Response and Collagen Deposition: A Pilot Study. [PDF]
, 2016 BackgroundExpiratory central airway collapse is an increasingly recognized abnormality of the central airways and may be present in as many as 22% of patients evaluated for chronic obstructive pulmonary disease and/or asthma.
Baxter +28 more
core +1 more source
The Fibroblast Growth Factor signaling pathway
Wiley Interdisciplinary Reviews: Developmental Biology, 2015 The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs).
D. Ornitz, N. Itoh
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