Results 11 to 20 of about 5,708,203 (270)

225Ac-Labeled Antibody for Fibroblast Activation Protein-Targeted Alpha Therapy

Chemical & Biomedical Imaging, 2023
Targeted alpha therapy (TAT) is an innovative approach in cancer treatment that aims to selectively deliver high-energy radiation to cancer cells while minimizing damage to healthy tissues. 225Ac, an alpha radionuclide with a half-life of 10 days and emitting 4 alpha particles and 2 beta particles in its decay chain, has shown promise for TAT ...
Hanbo Song, Mengxin Xu, Jie Cai, Junyi Chen, Yu Liu, Qi Su, Zhu Li, Zhibo Liu   +7 more
doaj   +4 more sources

Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule [PDF]

npj Precision Oncology, 2017
Diagnostics: Dual selection improves circulating tumor cell assay Using two selection markers, instead of one, can improve the sensitivity of a blood test for circulating tumor cells (CTCs). Steven A. Soper from the University of Kansas in Lawrence, USA,
Małgorzata A. Witek, Rachel D. Aufforth, Hong Wang, Joyce W. Kamande, Joshua M. Jackson, Swathi R. Pullagurla, Mateusz L. Hupert, Jerry Usary, Weiya Z. Wysham, Dawud Hilliard, Stephanie Montgomery, Victoria Bae-Jump, Lisa A. Carey, Paola A. Gehrig, Matthew I. Milowsky, Charles M. Perou, John T. Soper, Young E. Whang, Jen Jen Yeh, George Martin, Steven A. Soper   +20 more
doaj   +3 more sources

Design and validation of fibroblast activation protein alpha targeted imaging and therapeutic agents. [PDF]

Theranostics, 2020
Background: Cancer-associated fibroblasts (CAFs) comprise a major cell type in the tumor microenvironment where they support tumor growth and survival by producing extracellular matrix, secreting immunosuppressive cytokines, releasing growth factors, and facilitating metastases.
Roy J, Hettiarachchi SU, Kaake M, Mukkamala R, Low PS.   +4 more
europepmc   +4 more sources

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics. [PDF]

Mol Cell Proteomics, 2019
Fibroblast activation protein-alpha (FAP) is a cell-surface transmembrane-anchored dimeric protease. This unique, constitutively active serine protease has both dipeptidyl aminopeptidase and endopeptidase activities and can hydrolyze the post-proline bond.
Zhang HE, Hamson EJ, Koczorowska MM, Tholen S, Chowdhury S, Bailey CG, Lay AJ, Twigg SM, Lee Q, Roediger B, Biniossek ML, O'Rourke MB, McCaughan GW, Keane FM, Schilling O, Gorrell MD.   +15 more
europepmc   +5 more sources

Expression and role of fibroblast activation protein-alpha in microinvasive breast carcinoma [PDF]

Diagnostic Pathology, 2011
Background Diagnosis of ductal carcinoma in situ (DCIS) in breast cancer cases is challenging for pathologist due to a variety of in situ patterns and artefacts, which could be misinterpreted as stromal invasion. Microinvasion is detected by the presence
Hua Xing, Yu Lina, Huang Xiaoxiao, Liao Zexiao, Xian Qi   +4 more
doaj   +3 more sources

The effect of tranilast on fibroblast activation protein α (FAP-α) expression in normal and keloid fibroblasts in vitro [PDF]

Dermatology Review, 2017
Introduction . Tranilast (N-(3’,4’-demethoxycinnamoyl)-anthranilic acid) is an anti-allergic drug. Its mechanism of action is based on the inhibition of antigen-induced release of chemical mediators from mast cells and basophils. It also reveals antifibroproliferative activities.
Paweł P. Antończak, Magdalena Jurzak, Katarzyna Adamczyk, Agnieszka Garncarczyk, Magdalena Hartman-Petrycka   +4 more
openaire   +4 more sources

Bioluminescent Probe for Monitoring Endogenous Fibroblast Activation Protein-Alpha

Analytical Chemistry, 2019
Fibroblast activation protein-α (FAP), as a crucial member of cell surface glycoprotein, highly expresses in reactive fibroblasts of tumors and several fibrosis diseases. It is a potential target for drug design and also reported as a prodrug strategy to increase the therapeutic window of some anticancer agents.
Yuxing Lin, Zhao Ma, Zhenzhen Li, Yuqi Gao, Xiaojun Qin, Zheng Zhang, Guankai Wang, Lupei Du, Minyong Li   +8 more
openaire   +3 more sources

A synthetic urinary probe–coated nanoparticles sensitive to fibroblast activation protein α for solid tumor diagnosis

International Journal of Nanomedicine, 2017
Xinwei Feng,1,* Qifan Wang,1,* Yuehua Liao,1 Xie Zhou,2 Yidan Wang,3 Wanli Liu,4 Ge Zhang1 1Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 2Department of Medical Chemistry, School ...
Feng XW, Wang QF, Liao YH, Zhou X, Wang YD, Liu WL, Zhang G   +6 more
doaj   +1 more source

Non‐Viral Cytokine‐Inducible SH2 Containing Protein Locus‐Specific Integrated Fibroblast Activation Protein Alpha‐Targeting Chimeric Antigen Receptor T Cells Achieve Potent Antitumor Efficacy in Glioblastoma [PDF]

MedComm
Chimeric antigen receptor T (CAR‐T) cells have been used to treat patients with glioblastoma (GBM) in clinical trial settings by targeting GBM‐associated antigens. However, the efficacy of these CAR‐T cells remains limited mainly due to the heterogeneous
Xin Dong, Yao Sun, Yuetong Guo, Jiao Wang, Fei Wang, Ziming Wang, Ruizhen Li, Fei Xie, Tingting Tan, Baijie Cheng, Ronghan Huang, Shu Zhang, Xiaotong Lin, Zhaoze Guo, Hubing Wu, Hao Wu, Xubiao Zhang, Guozhu Xie   +17 more
doaj   +2 more sources

Anti-cancer effect of targeting fibroblast activation protein alpha in glioblastoma through remodeling macrophage phenotype and suppressing tumor progression. [PDF]

CNS Neurosci Ther, 2023
Miao Y, Deng Y, Liu J, Wang J, Hu B, Hao S, Wang H, Zhang Z, Jin Z, Zhang Y, Li C, Zhang P, Wan H, Zhang S, Feng J, Ji N.   +15 more
europepmc   +2 more sources