Results 21 to 30 of about 5,708,203 (270)

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α

Science, 2010
Tumor Vaccination Success Vaccination with tumor-specific antigens is one of several attempted therapies seeking to harness the immune system, but—unfortunately—this strategy has been unsuccessful, possibly because of the immunosuppressive properties of the tumor microenvironment.
Kraman, Matthew, Bambrough, Paul J, Arnold, James N, Roberts, Edward W, Magiera, Lukasz, Jones, James O, Gopinathan, Aarthi, Tuveson, David A, Fearon, Douglas T   +8 more
openaire   +4 more sources

Targeting fibroblast activation protein-α to treat renal fibrosis

Cellular & Molecular Biology Letters
Background Renal fibrosis is the common outcome of chronic renal disease. Currently, there are no effective therapies. Fibroblast activation and extracellular matrix accumulation are key processes driving renal fibrosis.
Li Gong, Xinyu Lu, Na Ma, Tao Lu, Yuhong Gong, Liwei Hao, Weikang Xu, Qianbing Zhang, Xiaolan Chen, Qinglin Mo, Jiexing Tan, Henrique de Paula Lemos, Alexander Speechley, Wenwei Tu, Jianpiao Cai, Lei Huang, Wei Zhu, Sha Wu   +17 more
doaj   +3 more sources

Cross-species evaluation of fibroblast activation protein alpha as potential imaging target for soft tissue sarcoma: a comparative immunohistochemical study in humans, dogs, and cats. [PDF]

Front Oncol, 2023
This collection of data includes microscopic images of canine, feline and human soft tissue sarcoma as well as canine and feline healthy skin and inflammatory tissue samples. Each tissue section was stained using a routine hematoxylin and eosin stain and
Beer P, Pauli C, Haberecker M, Grest P, Beebe E, Fuchs D, Markkanen E, Krudewig C, Nolff MC.   +8 more
europepmc   +2 more sources

Fibroblast heterogeneity in non-small cell lung cancer and optical imaging targeting fibroblast activation protein [PDF]

, 2023
Cancer associated fibroblasts (CAFs) are one of the predominant cell types of non-small cell lung cancer (NSCLC) tumour stroma. This thesis will investigate fibroblast heterogeneity in NSCLC; defining their phenotype by expression of CAF markers ...
Mathieson, Layla
core   +1 more source

Cell-specific expression of the FAP gene is regulated by enhancer elements

Frontiers in Molecular Biosciences, 2023
Fibroblast activation protein (FAP) is an integral membrane serine protease that acts as both dipeptidyl peptidase and collagenase. In recent years, FAP has attracted considerable attention due to its specific upregulation in multiple types of tumor cell
Dina V. Antonova, Dmitry A. Gnatenko, Elena S. Kotova, Victor V. Pleshkan, Victor V. Pleshkan, Alexey I. Kuzmich, Alexey I. Kuzmich, Dmitry A. Didych, Eugene D. Sverdlov, Irina V. Alekseenko, Irina V. Alekseenko, Irina V. Alekseenko   +11 more
doaj   +1 more source

Chemotactic activity of platelet alpha granule proteins for fibroblasts. [PDF]

The Journal of cell biology, 1983
At sites of blood vessel injury, platelets release numerous substances that may have biological activities influencing cellular responses. In this study we examined separately the chemotactic activity for fibroblasts of three highly purified proteins obtained from platelet alpha granules: platelet factor 4 (PF4), platelet-derived growth factor (PDGF ...
R M, Senior, G L, Griffin, J S, Huang, D A, Walz, T F, Deuel   +4 more
openaire   +2 more sources

Expression of fibroblast activation protein alpha in odontogenic keratocyst and ameloblastoma: A cross-sectional immunohistochemical study

Journal of Orofacial Sciences, 2023
Introduction: Cancer has always been a mystery for the researcher, healthcare providers, and even patients. This could be because of the unexplored journey of a cell from its physiological to cancerous form.
Sandhya Tamgadge, Treville Pereira
doaj   +1 more source

Radiation-induced FAP + fibroblasts are involved in keloid recurrence after radiotherapy

Frontiers in Cell and Developmental Biology, 2022
Background: Keloid scars (KSs), which are composed of abnormal hyperplastic scar tissue, form during skin wound healing due to excessive fibroblast activation and collagen secretion.
Yan Gao, Xue Hou, Yuyin Dai, Ting Yang, Kexin Chen   +4 more
doaj   +1 more source

Molecular networks in FGF signaling: Flotillin-1 and Cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2 [PDF]

, 2012
Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Traub Stephanie, Tomasovic, Ana, Stephanie Traub, Ana Tomasovic, Ana Tomasovic (189773), Ritva Tikkanen (189783), Tikkanen Ritva, Tikkanen, Ritva, Traub, Stephanie, Tomasovic Ana, Ritva Tikkanen, Stephanie Traub (189777)   +11 more
core   +2 more sources

Arecoline Enhances Phosphodiesterase 4A Activity to Promote Transforming Growth Factor-β-Induced Buccal Mucosal Fibroblast Activation via cAMP-Epac1 Signaling Pathway

Frontiers in Pharmacology, 2021
Chewing areca nut (betel quid) is strongly associated with oral submucous fibrosis (OSF), a pre-cancerous lesion. Among the areca alkaloids, arecoline is the main agent responsible for fibroblast proliferation; however, the specific molecular mechanism ...
Bo Zhang, Lihua Gao, Chunsheng Shao, Mingsi Deng, Liangjian Chen   +4 more
doaj   +1 more source