Results 221 to 230 of about 316,930 (256)
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The Unconventional Secretory Machinery of Fibroblast Growth Factor 2
Traffic, 2011Unconventional secretory proteins represent a subpopulation of extracellular factors that are exported from eukaryotic cells by mechanisms that do not depend on the endoplasmic reticulum and the Golgi complex. Various pathways have been implicated in unconventional secretion including those involving intracellular membrane‐bound intermediates and ...
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Journal of Neuroscience Research, 2011
AbstractNeurogenesis within the adult brain is restricted to selected areas, one of which is the dentate gyrus (DG). Several growth factors have been reported to affect neurogenesis in the adult DG. However, a role of fibroblast growth factor‐2 (FGF‐2) in adult hippocampal neurogenesis has not been firmly established.
Werner, Sandra +2 more
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AbstractNeurogenesis within the adult brain is restricted to selected areas, one of which is the dentate gyrus (DG). Several growth factors have been reported to affect neurogenesis in the adult DG. However, a role of fibroblast growth factor‐2 (FGF‐2) in adult hippocampal neurogenesis has not been firmly established.
Werner, Sandra +2 more
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Journal of Cellular Biochemistry, 2007
AbstractProgress in FGF‐2 gene therapy has been hampered by the difficulty in achieving therapeutic levels of FGF‐2 secretion. This study tested whether the addition of BMP2/4 hybrid secretion signal to the FGF‐2 gene and mutation of cys‐70 and cys‐88 to serine and asparagine, respectively, would increase the stability and secretion of active FGF‐2 ...
Shin-Tai, Chen +4 more
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AbstractProgress in FGF‐2 gene therapy has been hampered by the difficulty in achieving therapeutic levels of FGF‐2 secretion. This study tested whether the addition of BMP2/4 hybrid secretion signal to the FGF‐2 gene and mutation of cys‐70 and cys‐88 to serine and asparagine, respectively, would increase the stability and secretion of active FGF‐2 ...
Shin-Tai, Chen +4 more
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Neutralization of Fibroblast Growth Factor-2 Reduces Intraarticular Adhesions
Clinical Orthopaedics and Related Research, 2001Adhesion is a serious complication after trauma or surgery. Because adhesion formation is essentially a fibrogenetic process, a series of growth factors are assumed to be involved in its development. If this is true, it may be possible that inhibition of the growth factor activity suppresses adhesion formation. The current study was conducted to verify
N, Fukui +4 more
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Fibroblast Growth Factor-2, Bone Homeostasis and Fracture Repair
Current Pharmaceutical Design, 2013There remains a great need to develop therapeutic agents to treat critical size defects and non-union fractures and one of the potential agents is recombinant human fibroblast growth factor 2 (FGF-2). We discuss the function of FGF-2 in bone formation, bone resorption, and downstream signaling pathways and review the role of exogenous FGF-2 in fracture
Yurong, Fei +2 more
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The role of fibroblast growth factor-2 (FGF-2) in hematopoiesis
Progress in Growth Factor Research, 1995Basic fibroblast growth factor (bFGF or FGF-2) is an angiogenic and pleiotropic growth factor involved in the proliferation and differentiation of numerous cell types. It is expressed mostly in tissues of mesoderm and neuroectoderm origin, and is thought to play an important role in the mesoderm induction.
M, Allouche, A, Bikfalvi
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Ceskoslovenska fysiologie, 2005
Fibroblast growth factor-2 is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. FGF-2 occurs in several isoforms resulting from alternative initiations of traslation: an 18 kDa cytoplasmic isoform and four larger molecular weight nuclear isoforms (22, 22.5, 24 and 34 ...
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Fibroblast growth factor-2 is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. FGF-2 occurs in several isoforms resulting from alternative initiations of traslation: an 18 kDa cytoplasmic isoform and four larger molecular weight nuclear isoforms (22, 22.5, 24 and 34 ...
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Role of Fibroblast Growth Factor-2 in Astrogliosis
2002Astrocytes comprise the most numerous cellular element of the brain. Though once thought to merely provide structural support for neurons, astrocytes are now known to participate in many aspects of normal nervous system development and function, including neuronal migration, synaptogenesis, induction of the blood-brain-barrier, metabolic support of ...
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