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Physiological Actions of Fibroblast Growth Factor-23 [PDF]
Frontiers in Endocrinology, 2018 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney. At physiological concentrations of the hormone, the endocrine actions of FGF23 in the kidney are αKlotho ...
Reinhold G. Erben
doaj +3 more sources
Fibroblast Growth Factor-23—A Potential Uremic Toxin [PDF]
Toxins, 2016 Fibroblast growth factor-23 (FGF23) is a circulating member of the FGF family produced mainly by the osteocytes and osteoblasts that can act as a hormone.
Piotr Kuczera +2 more
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A Case of Hyperphosphatemia and Elevated Fibroblast Growth Factor 23: A Brief Review of Hyperphosphatemia and Fibroblast Growth Factor 23 Pathway [PDF]
Kidney International Reports, 2017 Phosphate homeostasis is a complex process involving communication among bones, kidneys, and other organ systems.1, 2 This is tightly regulated through parathyroid hormone (PTH) and bone-derived fibroblast growth factor 23 (FGF23).1, 2, 3 Disruption of either pathway has been associated with a number of disorders resulting in hypo- or hyperphosphatemia.
Joseph Wang +6 more
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Phosphate and fibroblast growth factor 23 in diabetes [PDF]
Clinical Science, 2021 AbstractDiabetes is associated with a strongly elevated risk of cardiovascular disease, which is even more pronounced in patients with diabetic nephropathy. Currently available guideline-based efforts to correct traditional risk factors are only partly able to attenuate this risk, underlining the urge to identify novel treatment targets.
Amarens van der Vaart +4 more
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Fibroblast Growth Factor 23 [PDF]
Journal of the American Society of Nephrology, 2005 Although phosphate is important in skeletal mineralization, energy metabolism, and multiple enzymatic processes, little has been understood about the regulation of phosphate in health and disease until recently.
Erik A, Imel, Michael J, Econs
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Fibroblast Growth Factor 23 and Inflammation in CKD [PDF]
Clinical Journal of the American Society of Nephrology, 2012 Summary Background and objectives Levels of fibroblast growth factor 23 (FGF23) and inflammatory markers are commonly elevated in CKD, and each is associated with adverse clinical outcomes. This study tested the hypothesis that FGF23 is independently associated with inflammation in CKD.
Jair, Munoz Mendoza +14 more
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How Fibroblast Growth Factor 23 Works [PDF]
Journal of the American Society of Nephrology, 2007 There is a discontinuum of hereditary and acquired disorders of phosphate homeostasis that are caused by either high or low circulating levels of the novel phosphaturic hormone fibroblastic growth factor 23 (FGF23). Disorders that are caused by high circulating levels of FGF23 are characterized by hypophosphatemia, decreased production of 1,25 ...
Shiguang, Liu, L Darryl, Quarles
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Fibroblast growth factor 23: fueling the fire [PDF]
Kidney International, 2016 In chronic kidney disease, systemic inflammation is common and associated with mortality. The present study demonstrates that fibroblast growth factor 23 (FGF23) contributes to uremic inflammation by increasing hepatic expression and secretion of inflammatory cytokines.
Hanudel, Mark +2 more
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Fibroblast Growth Factor-23 and a Vegetarian Diet [PDF]
Journal of Renal Nutrition, 2020 Sparse data exist on population distributions of serum fibroblast growth factor-23 (FGF23) levels from developing, middle-income economies. FGF23 levels may differ substantially across regions based on differences in diet and urbanization. In a population-based study from North India, we tested the hypothesis that urinary phosphate excretion and FGF23 ...
Shuchi Anand +5 more
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Fibroblast Growth Factor–23 and Cardiac Structure and Function [PDF]
, 2014 Background: Fibroblast growth factor–23 (FGF‐23) is a phosphaturic factor previously associated with left ventricular hypertrophy and systolic dysfunction among individuals with chronic kidney disease.
Agarwal, Isha +7 more
core +1 more source