Results 21 to 30 of about 243,507 (261)
MicroRNA-297a regulates vascular calcification by targeting fibroblast growth factor 23 [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s): Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in ...
Shouhua Zheng +6 more
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Fibroblast growth factor 23, klotho and heparin
Current Opinion in Nephrology & Hypertension, 2023 Purpose of review Fibroblast growth factor (FGF) 23 is a bone-derived hormone that regulates phosphate and vitamin D metabolism by targeting the kidney. When highly elevated, such as in chronic kidney disease (CKD), FGF23 can also target the heart and induce pathologic remodeling.
Thomas, S. Madison +2 more
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Fibroblast Growth Factor 23 and Klotho in AKI [PDF]
Seminars in Nephrology, 2019 Acute kidney injury (AKI) is associated with many of the same mineral metabolite abnormalities that are observed in chronic kidney disease. These include increased circulating levels of the osteocyte-derived, vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23), and decreased renal expression of klotho, the co-receptor for FGF23.
Marta, Christov +3 more
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Fibroblast-growth factor 23 promotes terminal differentiation of ATDC5 cells. [PDF]
PLoS ONE, 2017 Fibroblast Growth Factor 23 (FGF23) is well documented as a crucial player in the systemic regulation of phosphate homeostasis. Moreover, loss-of-function experiments have revealed that FGF23 also has a phosphate-independent and local impact on ...
Mathilde Guibert +3 more
doaj +1 more source
Multiple faces of fibroblast growth factor-23 [PDF]
Current Opinion in Nephrology and Hypertension, 2016 This review examines the role of fibroblast growth factor-23 (FGF-23) in mineral metabolism, innate immunity and adverse cardiovascular outcomes.FGF-23, produced by osteocytes in bone, activates FGFR/α-Klotho (α-Kl) complexes in the kidney. The resulting bone-kidney axis coordinates renal phosphate reabsorption with bone mineralization, and creates a ...
Xiaobin, Han, L Darryl, Quarles
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Fibroblast Growth Factor 23 and the Last Mile [PDF]
Clinical Journal of the American Society of Nephrology, 2020 Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphorus balance by enhancing urinary phosphorus excretion and inhibiting the synthesis of 1,25-dihydroxyvitamin D [1,25(OH)2D] ([1][1]).
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A rare cause of atraumatic fractures: case series of four patients with tumor-induced osteomalacia
Clinical Diabetes and Endocrinology, 2020 Background Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome that presents with hypophosphatemia, bone pain, muscle weakness and fractures.
Debbie W. Chen +4 more
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Role of Fibroblast Growth Factor 23 (FGF23) and αKlotho in Cancer
Frontiers in Cell and Developmental Biology, 2021 Together with fibroblast growth factors (FGFs) 19 and 21, FGF23 is an endocrine member of the family of FGFs. Mainly secreted by bone cells, FGF23 acts as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3 ...
Franz Ewendt +2 more
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Fibroblast growth factor 23 and bone mineralisation [PDF]
International Journal of Oral Science, 2015 Fibroblast growth factor 23 (FGF23) is a hormone that is mainly secreted by osteocytes and osteoblasts in bone. The critical role of FGF23 in mineral ion homeostasis was first identified in human genetic and acquired rachitic diseases and has been further characterised in animal models.
Guo, Yu-Chen, Yuan, Quan
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Frontiers in Physiology, 2020 Dietary phosphorus oversupply wastes non-renewable natural resources and raises environmental concerns in animal agriculture. We hypothesized that laying hens do not need large safety margins for dietary phosphorus because of the existence of fibroblast ...
Zhouzheng Ren +8 more
doaj +1 more source