Basic fibroblast growth factor mediates carotid plaque instability through metalloproteinase-2 and –9 expression [PDF]
, 2004 OBJECTIVE(S): We hypothesized that basic fibroblast growth factor (bFGF) may exert a role in carotid plaque instability by regulating the expression of matrix metalloproteinases (MMP).
CAVALLARO, Antonino +6 more
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Tumor Biology, 2017 In the past decades, the oncogenic role of fibroblast growth factor receptor 2 has been demonstrated in a number of cancer types. However, studies have reported contradictory findings concerning the correlation between fibroblast growth factor receptor 2
Gang Liu +3 more
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Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes. [PDF]
, 2011 INTRODUCTION: Cartilage degeneration driven by catabolic stimuli is a critical pathophysiological process in osteoarthritis (OA). We have defined fibroblast growth factor 2 (FGF-2) as a degenerative mediator in adult human articular chondrocytes ...
Chen, Di +6 more
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Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes [PDF]
, 2020 Fibroblast growth factors (FGFs) are key regulators of tissue development, homeostasis and repair, and abnormal FGF signalling is associated with various human diseases.
Ben-Yehuda Greenwald, Maya +9 more
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Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. [PDF]
, 2015 Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However,
Hamada, Yoshinosuke +7 more
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Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-beta 1-induced differentiation of human cardiac fibroblasts into myofibroblasts [PDF]
, 2018 Transforming growth factor-beta 1 (TGF-beta 1) is a potent inducer of fibroblast to myofibroblast differentiation and contributes to the pro-fibrotic microenvironment during cardiac remodeling.
Aquinas Liguori, Tacia Tavares +3 more
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Fibroblast growth factor 21 and bone homeostasis
Biomedical Journal, 2023 Fibroblast growth factor 21 (FGF21), a member of the FGF subfamily, is produced primarily in the liver and adipose tissue. The main function of FGF21 is to regulate energy metabolism of carbohydrates and lipids in the body through endocrine and other ...
Yan Tang, Mei Zhang
doaj
Fibroblast Growth Factor Receptor Functions in Glioblastoma
Cells, 2019 Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations
Ana Jimenez-Pascual +1 more
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BMC Urology, 2023 Background Dysregulation of the terminal differentiation of bladder urothelium is associated with the pathogenesis of urinary tract disorders. Fibroblast growth factor (Fgf)7 and Fgf10 stimulate urothelial proliferation; however, their roles in cellular ...
Kazuto Suda +6 more
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Expression of basic fibroblast growth factor is associated with poor outcome in non-Hodgkin's lymphoma [PDF]
It is now clear that angiogenesis and angiogenesis factors are important in the pathogenesis of haematological malignancies. High pretreatment levels of serum basic fibroblast growth factor have been shown to be associated with poor prognosis in patients
A Bikfalvi +28 more
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