Results 91 to 100 of about 498,608 (348)

Controlled release of Dextrin-conjugated growth factors to support growth and differentation of neural stem cells [PDF]

, 2018
An essential aspect of stem cell in vitro culture and in vivo therapy is achieving sustained levels of growth factors to support stem cell survival and expansion, while maintaining their multipotency and differentiation potential. This study investigated
Ferguson, Elaine L, Hardwicke, Joseph, Liu, Qian, Naseer, Sameza, Powell, Lydia C, Song, Bing, Thomas, David W., Young, Fraser I, Zhu, Bangfu   +8 more
core   +4 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis [PDF]

Proceedings of the National Academy of Sciences, 2011
Enhancing the maturity of the newly formed blood vessels is critical for the success of therapeutic angiogenesis. The maturation of vasculature relies on active participation of mural cells to stabilize endothelium and a basal level of relevant growth factors.
Hunghao, Chu, Jin, Gao, Chien-Wen, Chen, Johnny, Huard, Yadong, Wang   +4 more
openaire   +2 more sources

VEGF: An essential mediator of both angiogenesis and endochondral ossification [PDF]

, 2007
During bone growth, development, and remodeling, angiogenesis as well as osteogenesis are closely associated processes, sharing some essential mediators.
Dai, J, Rabie, ABM
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dry preserved multilayered fibroblast cell sheets are a new manageable tool for regenerative medicine to promote wound healing

Scientific Reports, 2022
This study investigated the therapeutic effects of dry-preserved multi-layered fibroblast cell sheets (dry sheets) on cutaneous ulcers. Dry sheets were prepared by air-drying multi-layered fibroblast cell sheets (living sheets) to cease their life ...
Yutaro Matsuno, Masashi Yanagihara, Koji Ueno, Toshiro Saito, Hiroshi Kurazumi, Ryo Suzuki, Shunsaku Katsura, Atsunori Oga, Kimikazu Hamano   +8 more
doaj   +1 more source

Effects of LL-37 on Gingival Fibroblasts: A Role in Periodontal Tissue Remodeling? [PDF]

, 2018
Mounting evidence suggests that the host defence peptide, LL-37, plays a role in both inflammation and in wound healing; however, the role of this peptide in the remodeling and maintenance of oral tissues is not yet fully understood.
Irwin, Chris R., Lundy, Fionnuala T, McCrudden, Maelíosa T. C., O'Donnell, Katherine   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Effects of fibroblast growth factor-2 on cell proliferation of cementoblasts

Journal of Dental Sciences, 2016
Background/purpose: Fibroblast growth factor (FGF)-2 is known as a signaling molecule that induces tissue regeneration. Little is known about the effect of FGF-2 on cementoblasts for periodontal and periapical regeneration.
Hui-Chieh Yu, Fu-Mei Huang, Shiuan-Shinn Lee, Cheng-Chia Yu, Yu-Chao Chang   +4 more
doaj   +1 more source

PSAT173 Weekly Supplementation with Vitamin D3 reduces 1,25(OH)2 vitamin D3 Measured by Mass Spectrometry, and increases Fibroblast-like growth factor 23 (FGF23) in Individuals with and without Primary Hyperparathyroidism (PHPT) [PDF]

, 2022
Shivani Sidana, Mohammad Ashraf Ganie, Moomin Hussain Bhat   +2 more
openalex   +1 more source