Results 31 to 40 of about 307,105 (258)

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +1 more source

Fibroblast Growth Factor-2 Induces Hepatocyte Growth Factor/Scatter Factor Expression in Osteoblasts* [PDF]

Endocrinology, 1999
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional growth factor with a major role in tissue morphogenesis and repair. It stimulates the proliferation of cells of the osteoblast and osteoclast lineages. Mitogenic factors playing a role in fracture repair may act by regulating HGF/SF expression or activity in bone-forming cells.
F, Blanquaert, A M, Delany, E, Canalis
openaire   +2 more sources

Effects of Fibroblast Growth Factor-2 on Longitudinal Bone Growth* [PDF]

Endocrinology, 1998
In vivo, fibroblast growth factor-2 (FGF-2) inhibits longitudinal bone growth. Similarly, activating FGF receptor 3 mutations impair growth in achondroplasia and thanatophoric dysplasia. To investigate the underlying mechanisms, we chose a fetal rat metatarsal organ culture system that would maintain growth plate histological architecture.
E E, Mancilla, F, De Luca, J A, Uyeda, F S, Czerwiec, J, Baron   +4 more
openaire   +2 more sources

Fibroblast growth factor‐2/platelet‐derived growth factor enhances atherosclerotic plaque stability [PDF]

Journal of Cellular and Molecular Medicine, 2019
AbstractIncreased immature neovessels contribute to plaque growth and instability. Here, we investigated a method to establish functional and stable neovessel networks to increase plaque stability. Rabbits underwent aortic balloon injury and were divided into six groups: sham, vector and lentiviral transfection with vascular endothelial growth factor‐A
Yang Mao, Xiao Qiong Liu, Yu Song, Chun Gang Zhai, Xing Li Xu, Lei Zhang, Yun Zhang   +6 more
openaire   +2 more sources

Topical fibroblast growth factor‐2 for treatment of chronic tympanic membrane perforations

Laryngoscope Investigative Otolaryngology, 2020
Objective To determine the efficacy of fibroblast growth factor‐2 (FGF‐2) in treating chronic nonhealing tympanic membrane (TM) perforations. Method Double‐blinded, randomized placebo controlled phase 2 clinical trial for patients with chronic TM ...
Felipe Santos, Edina Shu, Daniel J. Lee, David H. Jung, Alicia M. Quesnel, Konstantina M. Stankovic, Dunia E. Abdul‐Aziz, Camden P. Bay, Amy Quinkert, D. Bradley Welling   +9 more
doaj   +1 more source

Fibroblast Growth Factor 2 Augments Transforming Growth Factor Beta 1 Induced Epithelial-mesenchymal Transition in Lung Cell Culture Model

Iranian Journal of Allergy, Asthma and Immunology, 2020
Impaired lung epithelial cell regeneration following injury may contribute to the development of pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) is a critical event in embryonic development, wound healing following injury, and even cancer ...
Lamis M.F. El-Baz, Nahla M. Shoukry, Hani S. Hafez, Robert D. Guzy, Mohamed Labib Salem   +4 more
doaj   +1 more source

Combined therapy of platelet-rich plasma and basic fibroblast growth factor using gelatin-hydrogel sheet for rotator cuff healing in rat models

Journal of Orthopaedic Surgery and Research, 2021
Introduction Excellent outcomes of arthroscopic rotator cuff repair for small and medium tears have been recently reported. However, re-tears after surgery have been a common complication after surgical repair of large and massive rotator cuff tears and ...
Takeshi Kataoka, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukohara, Takehiko Matsushita, Takahiro Niikura, Yasuhiko Tabata, Ryosuke Kuroda   +10 more
doaj   +1 more source

Thrombin‐mediated impairment of fibroblast growth factor‐2 activity [PDF]

The FEBS Journal, 2009
Thrombin generation increases in several pathological conditions, including cancer, thromboembolism, diabetes and myeloproliferative syndromes. During tumor development, thrombin levels increase along with several other molecules, including cytokines and angiogenic factors.
Totta P, De Cristofaro R, GIAMPIETRI, Claudia, Aguzzi MS, Faraone D, Capogrossi MC, Facchiano A.   +6 more
openaire   +5 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Toward a Novel Endogenous Anxiolytic Factor, Fibroblast Growth Factor 2 [PDF]

Biological Psychiatry, 2011
Among the 26% of Americans that showed a 12-month prevalence for a DSM-IV psychiatric disorder in 2005, most suffered from anxiety disorders (18.1%), followed by mood disorders at 9.5% (1). Therefore, anxiety disorders affect nearly one fifth of the population directly in their lifetime, albeit with substantial variation in range of affliction. Despite
Natalina, Salmaso, Flora M, Vaccarino
openaire   +2 more sources