Results 41 to 50 of about 749,302 (341)

Fibroblast growth factor 2 isoforms and cardiac hypertrophy [PDF]

Cardiovascular Research, 2004
Fibroblast growth factor 2 (FGF-2), a multifunctional polypeptide that affects cell growth and differentiation and becomes upregulated by stress, is expressed as AUG-initiated 18 kDa FGF-2 or CUG-initiated 21-34 kDa (hi-FGF-2) isoforms. Animal models have provided strong evidence that FGF-2 is essential for the manifestation of overload- and ...
Elissavet, Kardami, Zhi-Sheng, Jiang, Sarah K, Jimenez, Cheryl J, Hirst, Farah, Sheikh, Peter, Zahradka, Peter A, Cattini   +6 more
openaire   +2 more sources

Fibroblast growth factor 2 control of vascular tone [PDF]

Nature Medicine, 1998
Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion, inflammation, vessel injury/repair, wound healing, temperature regulation, digestion, exercise physiology, and metabolism. Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes ...
M, Zhou, R L, Sutliff, R J, Paul, J N, Lorenz, J B, Hoying, C C, Haudenschild, M, Yin, J D, Coffin, L, Kong, E G, Kranias, W, Luo, G P, Boivin, J J, Duffy, S A, Pawlowski, T, Doetschman   +14 more
openaire   +2 more sources

Role of Lactoferrinin Fibroblast Growth Factor 2 and Vascular Endothelial Growth Factor in Gingival Wounds [PDF]

Journal of Krishna Institute of Medical Sciences University, 2019
Background: Lactoferrin possesses the ability to promote migration and proliferation of fibroblasts which represents one potential reason for the use of lactoferrin to accelerate the healing process in gingival wounds.
Istiati, Intan Nirwana, Indra Surjono, Meircurius Dwi Condro Surboyo   +3 more
doaj  

Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice

Scientific Reports, 2021
Fibroblast growth factor 2 (FGF2) is important in musculoskeletal homeostasis, therefore the impact of reduction or Fgf2 knockout on skeletal muscle function and phenotype was determined.
C. Homer-Bouthiette, L. Xiao, Marja M. Hurley   +2 more
doaj   +1 more source

Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients

Journal of Translational Medicine, 2011
Background Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with
Smeland Eivind, Sorbye Sveinung W, Valkov Andrej, Kilvaer Thomas K, Bremnes Roy M, Busund Lill-Tove, Donnem Tom   +6 more
doaj   +1 more source

Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies

OncoTarget, 2016
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology. Mammalian FGF family members participate in multiple signaling pathways by binding to heparan sulfate and FGF receptors (FGFR) with varying affinities.
Mohamed R. Akl, Poonam Nagpal, N. Ayoub, B. Tai, S. Prabhu, Catherine M. Capac, Matthew Gliksman, A. Goy, K. S. Suh, Stephen K. Suh   +9 more
semanticscholar   +1 more source

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +1 more source

Fibroblast Growth Factor-2 Induces Hepatocyte Growth Factor/Scatter Factor Expression in Osteoblasts* [PDF]

Endocrinology, 1999
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional growth factor with a major role in tissue morphogenesis and repair. It stimulates the proliferation of cells of the osteoblast and osteoclast lineages. Mitogenic factors playing a role in fracture repair may act by regulating HGF/SF expression or activity in bone-forming cells.
F, Blanquaert, A M, Delany, E, Canalis
openaire   +2 more sources

Effects of Fibroblast Growth Factor-2 on Longitudinal Bone Growth* [PDF]

Endocrinology, 1998
In vivo, fibroblast growth factor-2 (FGF-2) inhibits longitudinal bone growth. Similarly, activating FGF receptor 3 mutations impair growth in achondroplasia and thanatophoric dysplasia. To investigate the underlying mechanisms, we chose a fetal rat metatarsal organ culture system that would maintain growth plate histological architecture.
E E, Mancilla, F, De Luca, J A, Uyeda, F S, Czerwiec, J, Baron   +4 more
openaire   +2 more sources

Fibroblast growth factor‐2/platelet‐derived growth factor enhances atherosclerotic plaque stability [PDF]

Journal of Cellular and Molecular Medicine, 2019
AbstractIncreased immature neovessels contribute to plaque growth and instability. Here, we investigated a method to establish functional and stable neovessel networks to increase plaque stability. Rabbits underwent aortic balloon injury and were divided into six groups: sham, vector and lentiviral transfection with vascular endothelial growth factor‐A
Yang Mao, Xiao Qiong Liu, Yu Song, Chun Gang Zhai, Xing Li Xu, Lei Zhang, Yun Zhang   +6 more
openaire   +2 more sources