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Upstream Regulators of Fibroblast Growth Factor 23 [PDF]

Frontiers in Endocrinology, 2021
Fibroblast growth factor 23 (FGF23) has been described as an important regulator of mineral homeostasis, but has lately also been linked to iron deficiency, inflammation, and erythropoiesis. FGF23 is essential for the maintenance of phosphate homeostasis
Danielle M. A. Ratsma, M. Carola Zillikens, Bram C. J. van der Eerden   +2 more
doaj   +4 more sources

Physiological Actions of Fibroblast Growth Factor-23 [PDF]

Frontiers in Endocrinology, 2018
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney. At physiological concentrations of the hormone, the endocrine actions of FGF23 in the kidney are αKlotho ...
Reinhold G. Erben
doaj   +4 more sources

Fibroblast growth factor 23, klotho and heparin

Current Opinion in Nephrology & Hypertension, 2023
Purpose of review Fibroblast growth factor (FGF) 23 is a bone-derived hormone that regulates phosphate and vitamin D metabolism by targeting the kidney.
S. Thomas, Qing Li, C. Faul
semanticscholar   +3 more sources

Phosphate and fibroblast growth factor 23 in diabetes [PDF]

Clinical Science, 2021
Diabetes is associated with a strongly elevated risk of cardiovascular disease, which is even more pronounced in patients with diabetic nephropathy. Currently available guideline-based efforts to correct traditional risk factors are only partly able to ...
A. van der Vaart, Stanley M H Yeung, P. V. van Dijk, S. Bakker, M. D. de Borst   +4 more
semanticscholar   +3 more sources

Fibroblast Growth Factor-23—A Potential Uremic Toxin [PDF]

Toxins, 2016
Fibroblast growth factor-23 (FGF23) is a circulating member of the FGF family produced mainly by the osteocytes and osteoblasts that can act as a hormone.
Piotr Kuczera, Marcin Adamczak, Andrzej Wiecek   +2 more
doaj   +4 more sources

Fibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia is defined as the loss of muscle mass, strength, and/or performance. It is strongly associated with all‐cause mortality. Fibroblast growth factor 23 (FGF23) is markedly elevated in patients with chronic kidney disease, especially ...
Limy Wong, Rachel Kenny, Jenny Y. Y. Ooi, Yung Shing Tsang, Emily Schembri, Lawrence P. McMahon   +5 more
doaj   +2 more sources

Role of Fibroblast Growth Factor 23 (FGF23) and αKlotho in Cancer

Frontiers in Cell and Developmental Biology, 2021
Together with fibroblast growth factors (FGFs) 19 and 21, FGF23 is an endocrine member of the family of FGFs. Mainly secreted by bone cells, FGF23 acts as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3 ...
Franz Ewendt, Martina Feger, Michael Föller   +2 more
doaj   +2 more sources

Il Fibroblast Growth Factor-23 (FGF-23)

Giornale di Clinica Nefrologia e Dialisi, 2018
Negli ultimi due decenni, l'identificazione delle proprietà biologiche del Fibroblast Growth Factor 23 (FGF23) ha notevolmente ampliato le conoscenze sulla regolazione endocrina e paracrina dell'omeostasi dei fosfati e sulle relazioni intercorrenti tra ...
D. Rendina, G. De Filippo, R. Muscariello, F. De Pascale, P. Strazzullo   +4 more
doaj   +4 more sources

Fibroblast growth factor 23 and fibroblast growth factor receptor 4 promote cardiac metabolic remodeling in chronic kidney disease. [PDF]

Kidney Int
Chronic kidney disease (CKD) is a global health epidemic that greatly increases mortality due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiac injury in CKD. High serum levels of fibroblast growth factor (
Fuchs MAA, Burke EJ, Latic N, Murray SL, Li H, Sparks MA, Abraham D, Zhang H, Rosenberg P, Saleem U, Hansen A, Miller SE, Ferreira D, Hänzelmann S, Hausmann F, Huber T, Erben RG, Fisher-Wellman K, Bursac N, Wolf M, Grabner A.   +20 more
europepmc   +2 more sources

Strategies to lower fibroblast growth factor-23 bioactivity.

Nephrology Dialysis Transplantation, 2021
Fibroblast growth factor-23 (FGF23) is a circulating hormone derived from the bone whose release is controlled by many factors and exerts a multitude of systemic actions. There are congenital and acquired disorders of increased and decreased FGF23 levels.
D. Verbueken, O. Moe
semanticscholar   +3 more sources