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Il Fibroblast Growth Factor-23 (FGF-23) [PDF]

Giornale di Clinica Nefrologica e Dialisi, 2011
Negli ultimi due decenni, l'identificazione delle proprietà biologiche del Fibroblast Growth Factor 23 (FGF23) ha notevolmente ampliato le conoscenze sulla regolazione endocrina e paracrina dell'omeostasi dei fosfati e sulle relazioni intercorrenti tra asse rene-intestino-tessuto osseo e sistema biologico vitamina D-FTH-calcio-fosfati.
D. Rendina, G. De Filippo, R. Muscariello, F. De Pascale, P. Strazzullo   +4 more
doaj   +6 more sources

Upstream Regulators of Fibroblast Growth Factor 23 [PDF]

Frontiers in Endocrinology, 2021
Fibroblast growth factor 23 (FGF23) has been described as an important regulator of mineral homeostasis, but has lately also been linked to iron deficiency, inflammation, and erythropoiesis. FGF23 is essential for the maintenance of phosphate homeostasis in the body and activating mutations in the gene itself or inactivating mutations in its upstream ...
Danielle M A Ratsma, Bram C. J. van der Eerden, M. Carola Zillikens   +2 more
openaire   +4 more sources

Phosphate and fibroblast growth factor 23 in diabetes [PDF]

Clinical Science, 2021
Diabetes is associated with a strongly elevated risk of cardiovascular disease, which is even more pronounced in patients with diabetic nephropathy. Currently available guideline-based efforts to correct traditional risk factors are only partly able to ...
Bakker, Stephan J L, de Borst, Martin H, van der Vaart, Amarens, van Dijk, Peter R, Yeung, Stanley M H   +4 more
core   +4 more sources

Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation. [PDF]

J Biol Chem, 2023
The bone-derived hormone fibroblast growth factor-23 (FGF23) has recently received much attention due to its association with chronic kidney disease and cardiovascular disease progression.
Radvanyi Z, Yoo EJ, Kandasamy P, Salas-Bastos A, Monnerat S, Refardt J, Christ-Crain M, Hayashi H, Kondo Y, Jantsch J, Rubio-Aliaga I, Sommer L, Wagner CA, Hediger MA, Kwon HM, Loffing J, Pathare G.   +16 more
europepmc   +6 more sources

Fibroblast growth factor 23, klotho and heparin. [PDF]

Curr Opin Nephrol Hypertens, 2023
Purpose of review Fibroblast growth factor (FGF) 23 is a bone-derived hormone that regulates phosphate and vitamin D metabolism by targeting the kidney. When highly elevated, such as in chronic kidney disease (CKD), FGF23 can also target the heart and induce pathologic remodeling.
Thomas SM, Li Q, Faul C.
europepmc   +3 more sources

Fibroblast Growth Factor–23 and Cardiac Structure and Function [PDF]

Journal of the American Heart Association, 2014
Background: Fibroblast growth factor–23 (FGF‐23) is a phosphaturic factor previously associated with left ventricular hypertrophy and systolic dysfunction among individuals with chronic kidney disease.
Agarwal, Isha, Ide, Noriko, Ix, Joachim H., Kestenbaum, Bryan, Lanske, Beate, Mukamal, Kenneth J., Schiller, Nelson B., Whooley, Mary A.   +7 more
core   +6 more sources

Fibroblast Growth Factor-23 and a Vegetarian Diet [PDF]

Journal of Renal Nutrition, 2020
Sparse data exist on population distributions of serum fibroblast growth factor-23 (FGF23) levels from developing, middle-income economies. FGF23 levels may differ substantially across regions based on differences in diet and urbanization. In a population-based study from North India, we tested the hypothesis that urinary phosphate excretion and FGF23 ...
Shuchi Anand, Ram Jagannathan, Ruby Gupta, Sailesh Mohan, Dorairaj Prabhakaran, Myles Wolf   +5 more
openaire   +3 more sources

Potassium intake, fibroblast growth factor 23 and clinical outcomes [PDF]

, 2023
Chronic kidney disease (CKD) is a major cause of cardiovascular disease and premature death. Characteristic of some patients with CKD is, among other things, a tendence to develop high levels of phosphate and fibroblast growth factor (FGF23) in the blood,
Yeung, Stanley
core   +1 more source

Oral Acid Load Down-Regulates Fibroblast Growth Factor 23 [PDF]

, 2022
Increased dietary acid load has a negative impact on health, particularly when renal function is compromised. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that is elevated during renal failure. The relationship between metabolic acidosis
Aguilera Tejero, Escolástico, Espartero, Azahara, López, Ignacio, Muñoz-Castañeda, Juan R., Pineda, Carmen, Raya, Ana I., Rodríguez, Mariano, Ríos, Rafael, Vidal, Ángela   +8 more
core   +1 more source

Fibroblast growth factor 23: fueling the fire [PDF]

Kidney International, 2016
In chronic kidney disease, systemic inflammation is common and associated with mortality. The present study demonstrates that fibroblast growth factor 23 (FGF23) contributes to uremic inflammation by increasing hepatic expression and secretion of inflammatory cytokines.
Hanudel, Mark, Jüppner, Harald, Salusky, Isidro B   +2 more
openaire   +5 more sources