Results 81 to 90 of about 8,552 (153)

Tumor-Induced Osteomalacia in a Patient With FGF23-Amplified Lung Adenocarcinoma and FGF23-Deleted SCLC: Case Report

JTO Clinical and Research Reports
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by ectopic fibroblast growth factor-23 (FGF23) production. We report a unique case of a 78-year-old female patient with refractory hypophosphatemia, ultimately diagnosed as ...
Marcello Moro Queiroz, MD, Ricardo Dahmer Tiecher, MD, João Felipe Lima Feldmann, MD, Elisangela Monteiro Coser, BSc, Mariana Vargas Cruz, PhD, Livia Loureiro, PhD, Gabriela Franco Katz, MD, Marina Henkin Behar, MD, João Victor Machado Alessi, MD, Leonardo de Abreu Testagrossa, PhD, Anamaria Aranha Camargo, PhD, Paula Fontes Asprino, PhD, Fabiana Bettoni, PhD, Artur Katz, MD   +13 more
doaj   +1 more source

Deletion of cardiac fibroblast growth factor-23 beneficially impacts myocardial energy metabolism in left ventricular hypertrophy

npj Metabolic Health and Disease
Left ventricular hypertrophy (LVH) is associated with increased cardiac expression of fibroblast growth factor-23 (FGF23) in mice and men. To further elucidate the role of cardiac FGF23 in LVH, we specifically ablated Fgf23 in cardiomyocytes, and ...
Nejla Latic, Arezou Lari, Na Sun, Ana Zupcic, Mhaned Oubounyt, Juliana Falivene, Achim Buck, Martin Hofer, Wenhan Chang, Wolfgang M. Kuebler, Jan Baumbach, Axel K. Walch, Alexander Grabner, Reinhold G. Erben   +13 more
doaj   +1 more source

FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation

BMC Biotechnology, 2018
Background High level of serum fibroblast growth factor 23 (FGF23) is implicated in the development and progression of diabetic nephropathy (DN), making it a crucial factor in the pathogenesis of DN.
Xiaomin Zhang, Kaiwen Guo, Feng Xia, Xinyu Zhao, Zhifeng Huang, Jianlou Niu   +5 more
doaj   +1 more source

Phosphaturic mesenchymal tumor of the nasal cavity: Clinicopathologic correlation is essential for diagnosis

Human Pathology: Case Reports, 2019
Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm in which the tumor cells produce fibroblast growth factor 23 (FGF23), leading to oncogenic osteomalacia and thus a distinct clinical presentation.
Aidan Kerr, Ryan Rimmer, Marc R. Rosen, James J. Evans, Madalina Tuluc, Stacey K. Mardekian   +5 more
doaj   +1 more source

Studies on the regulation of the phosphaturic hormone fibroblast growth factor 23 (FGF23)

, 2019
Fibroblasten-Wachstumsfaktor 23 (FGF23) ist ein aus dem Knochen stammendes Hormon, das den Blutspiegel von Phosphat und aktivem Vitamin D reguliert. Bei diversen menschlichen Erkrankungen, wie Nieren- oder Herz-Kreislauf-Erkrankungen, ist der FGF23-Spiegel verändert, wodurch es auch seine klinische Relevanz erlangt.
openaire   +2 more sources

Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes

Cell Reports
Summary: With exercise, muscle and bone produce factors with beneficial effects on brain, fat, and other organs. Exercise in mice increased fibroblast growth factor 23 (FGF23), urine phosphate, and the muscle metabolite L-β-aminoisobutyric acid (L-BAIBA),
Eijiro Sakamoto, Yukiko Kitase, Alexander J. Fitt, Zewu Zhu, Kamal Awad, Marco Brotto, Kenneth E. White, Steven S. Welc, Clemens Bergwitz, Lynda F. Bonewald   +9 more
doaj   +1 more source

Infigratinib Reduces Fibroblast Growth Factor 23 (FGF23) and Increases Blood Phosphate in Tumor-Induced Osteomalacia. [PDF]

JBMR Plus, 2022
Hartley IR, Roszko KL, Li X, Pozo K, Streit J, Del Rivero J, Magone MT, Smith MR, Vold R, Dambkowski CL, Collins MT, Gafni RI.   +11 more
europepmc   +1 more source

Research progress on the biological role of serum soluble α-Klotho in chronic kidney diseases

Linchuang shenzangbing zazhi, 2020
α-Klotho is an anti-aging protein, which has been reported to bind with fibroblast growth factor receptor-1(FGFR1) to become a transmembrane co-receptor of fibroblastic growth factor-23(FGF23), thereby mediating FGF23/FGFR1/Klotho signaling to play a key
SUN Long, ZHU Guo-shuang, DENG Dan-fang, LIN La-mei, LI Ying-xia, WANG Xiao-qin   +5 more
doaj  

Organic phosphate but not inorganic phosphate regulates Fgf23 expression through MAPK and TGF-ꞵ signaling

iScience
Summary: One of the main regulators of phosphate homeostasis is fibroblast growth factor 23 (FGF23), secreted by osteocytes. The effects of organic versus inorganic dietary phosphate on this homeostasis are unclear.
Danielle M.A. Ratsma, Max Muller, Marijke Koedam, Johannes P.T.M. van Leeuwen, M. Carola Zillikens, Bram C.J. van der Eerden   +5 more
doaj   +1 more source

Fibroblast growth factor 23 (FGF23) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source